The Insulin-Resistance Inducing Factor Associated with Uremia

  • Dean H. Lockwood
  • Gary R. Hayes
  • Michael L. McCaleb
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 223)


Insulin resistance is a prominent feature of several clinical conditions including obesity, non-insulin dependent diabetes mellitus (Type II), fasting, glucocorticoid excess, myotonic dystrophy and uremia. Evidence for insulin resistance in chronic renal disease is provided by the demonstration of elevated circulating levels of insulin and a blunted glucose response to an injection of the hormone1. More direct evidence of insulin resistance is proyided by a reduction in insulin-stimulated glucose uptake by skeletal muscle when measured by the forearm perfusion technique2 or by the euglycemic insulin clamp3. In vitro studies in liver, muscle and fat from uremic rats have shown resistance of at least some parameters of insulin action4.


Insulin Resistance Insulin Action Myotonic Dystrophy Insulin Binding Uremic Patient 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Dean H. Lockwood
    • 1
  • Gary R. Hayes
    • 1
  • Michael L. McCaleb
    • 1
  1. 1.Endocrine-Metabolism Unit, Department of MedicineUniversity of Rochester School of Medicine and DentistryRochesterUSA

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