Aluminum an Uremic Toxin

  • Patrick C. D’Haese
  • Frank L. Van de Vyver
  • Ludwig V. Lamberts
  • Marc E. De Broe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 223)


Aluminum has historically been regarded as non essential, since up to now no physiological function could be ascribed to it. Environmental exposure to aluminum is virtually universal as aluminum constitutes a substantial part of the earth’s crust (8%) and is found in food, medicine and cosmetics. Besides this aluminum has a lot of industrial applications. Until recently, aluminum was generally considered to be a relatively nontoxic metal, which is reflected by the scarce and often wrong information presented in the literature dealing with the toxicology of trace elements. However, since it was found that aluminum is the causative factor in some dialysis-related diseases, the issue of the origin and physio-pathology of aluminum accumulation-toxicity in these patients has received the interest it deserves.


Uremic Toxin Aluminum Level Serum Aluminum Aluminum Accumulation Dialysis Encephalopathy 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Patrick C. D’Haese
    • 1
  • Frank L. Van de Vyver
    • 1
  • Ludwig V. Lamberts
    • 1
  • Marc E. De Broe
    • 1
  1. 1.Dept. of Nephrology-HypertensionUniversity of Antwerp, University Hospital AntwerpEdegem (Antwerpen)Belgium

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