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Parathyroid Hormone: A Uremic Toxin

  • Shaul G. Massry
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 223)

Abstract

A Sundry of clinical, biochemical and radiographic abnormalities occur in patients with advanced renal failure. These are listed in Table 1, and they constitute the uremic syndrome. Their pathogenesis have been attributed to uremic toxins.

Keywords

Parathyroid Hormone Parathyroid Gland Glucose Intolerance Primary Hyperparathyroidism Secondary Hyperparathyroidism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Massry, SG: Parathyroid hormone and the uremic manifestations. Contrib Nephrol 20:84–91, 1980.PubMedGoogle Scholar
  2. 2.
    Babb, AL, Popovitch RP, Christopher, TG, et al: The genesis of the square meter-hour hypothesis. Trans Amer Soc Artif Internal Organs 17:81–91, 1971.Google Scholar
  3. 3.
    Alfrey, AG, LeGendre, GR, Kaehny, WD: The dialysis encephalopathy. N Engl J Med 294:184–188, 1976.PubMedCrossRefGoogle Scholar
  4. 4.
    Berlyne, GM: Aluminum toxicity in man. Miner Elect Metab 2:71–73, 1979.Google Scholar
  5. 5.
    Massry, SG: Is parathyroid hormone a uremic toxin? Nephron 19:125–130, 1977.PubMedCrossRefGoogle Scholar
  6. 6.
    Pappenheimer, AM, Wilens, SL: Enlargement of the parathyroid glands in renal disease. Am J Pathol 11:73–91, 1935.PubMedGoogle Scholar
  7. 7.
    Roth, SI, Marshall, RB: Pathology and ultrastructure of the human parathyroid glands in chronic renal failure. Arch Intern Med 124:390–407, 1969.CrossRefGoogle Scholar
  8. 8.
    Katz, AD, Kaplan, L: Parathyroidectomy for hyperplasia in renal disease. Arch Surg 107:51–55, 1973.PubMedCrossRefGoogle Scholar
  9. 9.
    Berson, SA, Yallow, RS: Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma. Science 154:907–909, 1966.PubMedCrossRefGoogle Scholar
  10. 10.
    Massry, SG, Coburn, JW, Peacock, M: Turnover of endogenous parathyroid hormone in uremic patients and those undergoing hemodialysis. Trans Am Soc Artif Intern Organs 8:416–422, 1972.CrossRefGoogle Scholar
  11. 11.
    Massry, SG, Goldstein, DA: The search for uremic toxin(s) “X”: “X”=PTH. Clin Nephrol 11:181–189, 1979.PubMedGoogle Scholar
  12. 12.
    Wallach, S, Ballavia, JV, Shorr J: Tissue distributions of electrolyte, Ca47, and Mg28 in experimental hyper- and hypoparathyroidism. Endocrinology 78:16–28, 1966.PubMedCrossRefGoogle Scholar
  13. 13.
    Chausmer, AB, Sherman, BS, Wallach, S: The effect of parathyroid hormone on hepatic cell transport of calcium. Endocrinology 90:663–672, 1972.PubMedCrossRefGoogle Scholar
  14. 14.
    Borle, AB: Calcium metabolism at the cellular level. Fed Proc 30:1944–1950, 1973.Google Scholar
  15. 15.
    Bogin, E, Massry, SG, Levi, J: Effect of parathyroid hormone on osmotic fragility of human erythrocytes. J Clin Invest 69:1017–1025, 1982.PubMedCrossRefGoogle Scholar
  16. 16.
    Massry, SG, Coburn, JW, Hartenbower, DL: Mineral content of human skin in uremia: Effect of secondary hyperparathyroidism and hemodialysis. Proc Eur Dial Transplant Assoc 7:146–150, 1970.Google Scholar
  17. 17.
    Berkow, JW, Fine, BS, Zimmerman, LE: Unusual ocular calcification of hyperparathyroidism. Am J Ophthalmol 68:814–824, 1968.Google Scholar
  18. 18.
    Bernstein, DS, Pletka, P, Hartner, RS: Effect of total parathyroidectomy and uremia on the chemical composition of bone, skin, aorta and rats. Israel J Med Sci 7:513–514, 1971.PubMedGoogle Scholar
  19. 19.
    Kraikipanitch, S, Lindeman, RD, Yoenice, AA: Effect of azotemia and myocardial accumulation of calcium. Miner Elect Metab 1:12–20, 1978.Google Scholar
  20. 20.
    Arieff, AI, Massry, SG: CaIcium metabo1ism of brain in acute renal failure. J Clin Invest 53:387–392, 1974.PubMedCrossRefGoogle Scholar
  21. 21.
    Goldstein, DA, Chui, LA, Massry, SG: Effect of parathyroid hormone and uremia on peripheral nerve calcium and motor nerve conduction velocity. J Clin Invest 62:88–93, 1978.PubMedCrossRefGoogle Scholar
  22. 22.
    Rasmussen, H: Calcium as intracellular messenger in hormone action, in Massry SG, Letteri, JM, Ritz, E (eds): Regulation of Phosphate and Mineral Metabolism, New York, Plenum, pp 473–491, 1982.Google Scholar
  23. 23.
    Hirata, F, Axelrod, J: Enzymatic methylation of phosphot idylethanolamine increases erthrocyte membrane fluidity. Nature 275:219–220, 1978.PubMedCrossRefGoogle Scholar
  24. 24.
    Michell, RH: Inositol phospholipids and cell surface receptor function. Biochim Biophys Acta 415:81–147, 1975.PubMedGoogle Scholar
  25. 25.
    Gardner, JD: Regulation of pancreatic exocrine function in vitro: Initial steps in the actions of secretagogues. Ann Rev Physiol 41:55–66, 1979.CrossRefGoogle Scholar
  26. 26.
    Green, DE, Fry, M, Blondin, GA: Phospholipids as the molecular instruments of ion and solute transport in biological membrane. Proc Natl Acad Sci 77: 257–261, 1980.PubMedCrossRefGoogle Scholar
  27. 27.
    Lo, H, Lehotay, DC, Katz, D: Parathyroid hormonemediated incorporation of 32P orthophosphate into phosphatidic acid and phosphatidy1inositol in renal cortical slices. Endocr Res Conrnun 3:377–385, 1976.CrossRefGoogle Scholar
  28. 28.
    Molitoris, BA, Hruska, KA, Fishman, N: Effects of glucose and parathyroid hormone on renal handling of myoinositol by isolated perfused dog kidney. J Clin Invest 63:1110–1118, 1979.PubMedCrossRefGoogle Scholar
  29. 29.
    Brautbar, N, Chakaborty, J, Coats, J, Massry, SG: Calcium, parathyroid hormone and phospholipid turnover of human red blood cells. Miner Elect Metab 11:111–116, 1985.Google Scholar
  30. 30.
    Albright, F, Bauer, W, Ropes, M: Studies of calcium and phosphorus metabolism. J Clin Invest 7:139–181, 1929.PubMedCrossRefGoogle Scholar
  31. 31.
    Clarkson, B, Kowlessar, OD, Horwith, M: Clinical and metabolic study of a patient with malabsorption and hypoparathyroidism. Metabolism 9:1093–1106, 1960.PubMedGoogle Scholar
  32. 32.
    Landau, RL, Kappas, A: Anabolic hormones in hyperparathyroidism. Ann Intern Med 62:1223–1233, 1965.PubMedGoogle Scholar
  33. 33.
    King, RG, Stanbury, SW: Magnesium metabolism in primary hyperparathyroidism. Clin Sci 39:281–303, 1970.PubMedGoogle Scholar
  34. 34.
    Garber, AJ; Effect of parathyroid hormone on skeletal muscle protein and amino acid metabolism in the rat. J Clin Invest 71:1806–1821, 1983.PubMedCrossRefGoogle Scholar
  35. 35.
    Frohling, PT, Kokot, F, Cernacek, P: Relation between middle molecules and parathyroid hormone in patients with chronic renal failure. Miner Elect Metab 7:48–53, 1982.Google Scholar
  36. 36.
    Massry, SG: The toxic effects of parathyroid hormone in uremia. Seminars Nephrol 3:306–327, 1983.Google Scholar
  37. 37.
    Westervelt, FB, Schreiner, GE: The carbohydrate intolerance of uremic patients. Ann Intern Med 57:266–275, 1962.PubMedGoogle Scholar
  38. 38.
    Hampers, CL, Soeldoner, JS, Doak, PB, Merill, JP: Effect of chronic failure and hemodialysis on carbohydrate metabolism. J Clin Invest 45:1719–1731, 1966.PubMedCrossRefGoogle Scholar
  39. 39.
    Horton, ES, Johnson, C, Lebovitz, HE: Carbohydrate metabolism in uremia. Ann Intern Med 68:63–74, 1968.PubMedGoogle Scholar
  40. 40.
    De Fronzo, RA, Andres, R, Edgar, P, Waler, WG: Carbohydrate metabolism in uremia. A review Medicine 52:469–481, 1973.CrossRefGoogle Scholar
  41. 41.
    De Fronzo, RA, Alverstrand, A, Smith, D, Hendler, R, Hendler, E, Wahren, J: Insulin resistance in uremia. J Clin Invest 67:563–568, 1981.CrossRefGoogle Scholar
  42. 42.
    Samaan, NA, Freeman, RM: Growth hormone levels in severe renal failure. Metabolism 19:102–113, 1970.PubMedCrossRefGoogle Scholar
  43. 43.
    Lowrie, EG, Soeldner, JS, Hampers, CL, Merrill, JP: Glucose metabolism and insulin secretion in uremic, prediabetic, and normal subjects. J Lab Clin Med 76:603–615, 1970.PubMedGoogle Scholar
  44. 44.
    Hutching, RH, Hagstrom, RM, Scribner, BH: Glucose intolerance in patients on long-term intermittent dialysis. An Intern Med 65:275–285, 1966.Google Scholar
  45. 45.
    De Fronzo, RA: Pathogenesis of glucose intolerance in uremia. Metabolism 27:1866–1880, 1978.CrossRefGoogle Scholar
  46. 46.
    Ginsberg, H, Olefsky, JM, Reaven, GM: Evaluation of insulin resistance in patients with primary hyperparathyroidism. Proc Exp Biol Med 148:942–945, 1975.Google Scholar
  47. 47.
    Kim, H, Kalkhoff, RK, Costrini, NV, Cerletty, JM, Jacobson, M: Plasma insulin disturbances in primary hyperparathyroidism. J Clin Invest 50:2596–2605, 1971.PubMedCrossRefGoogle Scholar
  48. 48.
    De Fronzo, RA, Tobin, JD, Andres, R: Glucose clamp technique. A method for quantifying insulin secretion and resistance. Am J Physiol 237:E214–E223, 1979.Google Scholar
  49. 49.
    Akmal, M, Massry, SG, Goldstein, AD, Fanti, P, Weisz, A, DeFronzo, R: Role of parathyroid hormone in the glucose intolerance of chronic renal failure. J Clin Invest 75:1037–1044, 1985.PubMedCrossRefGoogle Scholar
  50. 50.
    Bevilacqua, S, Barrett, E., Farranini, E, Gusberg, R, Stewart, A, Richardson, L, Smith, D, DeFronzo, R: Lack of effect of parathyroid hormone on hepatic glucose metabolism in the dog. Metabolism 30:469–475, 1981.PubMedCrossRefGoogle Scholar
  51. 51.
    Mak, RH, Turner, C, Haycock, GB, Chantler, C: Secondary hyperparathyroidism and glucose intolerance in children with uremia. Kidney Int 24:5123–5133.Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Shaul G. Massry
    • 1
  1. 1.University of Southern California, School of MedicineLos AngelesUSA

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