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Production of Suppressor Factor by T-Cells from Mice Immunized with Pneumococcal Polysaccharide

  • Christopher E. Taylor
  • Rani Bright
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 225)

Abstract

Factor(s) derived from plate purified T-cell cultures obtained from mice 16 hr after immunization with Type III pneumococcal polysaccharide (SSS-III), suppressed the antibody response to SSS-III. Such suppression was antigen specific. Adsorption of the suppressor factor (SF) with SSS-III covalently bound to Sepharose 4B column did not alter the ability of SF to suppress the antibody response. However, adsorption of SF with Ig+(B) cells taken from mice 48 hr after immunization with an immunogenic dose (0.5 ug) of SSS-III, completely removed the suppressive activity. Suppression of the antibody response was observed only when SF was administered 24 hr before to 24 hr after immunization with SSS-III. These results suggest that antigen specific suppressor T cells release soluble factor(s) which acts directly on antigen-stimulated B cells or may inhibit the induction of amplifier T-cells.

Keywords

Antibody Response Spleen Cell Soluble Factor Suppressor Cell Recipient Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Christopher E. Taylor
    • 1
  • Rani Bright
    • 1
  1. 1.Department of Microbiology and ImmunologyThe Medical College of PennsylvaniaPhiladelphiaUSA

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