Modulation of T-Cell Functions by Peptide Hormones

  • Christopher J. Krco
  • Tu T. Nguyen
  • Vay Liang W. Go
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 225)


An immune response is a net result of a myriad set of cellular interactions, each interaction having multiple regulatory points. Although the nature of the regulatory factors is not fully known, the role of genetics, age, nutrition and circadium rhythm in affecting immunocompetence has been described (Rogers et al, 1979). More recently, it has been suggested that psychoneurological components may also be a potential source of immunomodulatory influences (Solomon, 1981; Riley, 1981; Fauman, 1982). Circumstantial evidence collected as a result of measuring the effects of central nervous system lesions, sympathectomy and emotional status on immunity have led to the concept of nerve mediated regulation of immune responses (Solomon, 1981; Riley, 1981; Jankovic and Isakovic, 1973). Whether denoted as “psychoimmunology”, “psychoneuroimmunology” or “neuroimmunomodula­tion”, the common denominator is the prediction that lymphoid cell function may be modulated as a consequence of the release of neuropep­tides within the lymphoid tissue microenvironment. Innervation of lymph nodes, spleen, and thymus have been described in several spe­cies. In vitro experimentation have indicated that some neuropeptides can augment or inhibit immune responses (Payan and Goetzl, 1985). While these data suggest that neuroendocrine substances may serve as immunomodulators there are discrepancies in the literature concerning the effects mediated by some neuropeptides.


Vasoactive Intestinal Peptide Central Nervous System Lesion Glucagon Receptor Mouse Lymphocyte Vasoactive Intestinal Peptide Receptor 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Christopher J. Krco
    • 1
  • Tu T. Nguyen
    • 2
  • Vay Liang W. Go
    • 2
  1. 1.Department of ImmunologyMayo Clinic Clinic and Medical SchoolRochesterUSA
  2. 2.Gastroenterology UnitMayo Clinic Clinic and Medical SchoolRochesterUSA

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