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A Peptide Binding Protein Which Plays a Role in Antigen Presentation

  • E. K. Lakey
  • J. A. Smith
  • E. Margoliash
  • S. K. Pierce
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 225)

Abstract

The helper T-cell recognition of globular protein antigens appears, in general, to require the intracellular processing of the antigen such that a peptide fragment containing the T-cell’s antigenic determinant is released, is transported to and held on the surface of an Ia expressing cell. However, the molecular details underlying these phenomena are largely unknown.

Keywords

Peptide Fragment Antigenic Peptide Antigenic Determinant Specific Peptide Binding Peptide Binding Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Finnegan, A., Smith, M. A., Smith, J. A., Berzofsky, J., Sachs, D. H., and Hodes, R. J., 1986, The T cell repertoire for recognition of a phylogenetically distant protein antigen, J. Exp. Med., 164: 897–910.PubMedCrossRefGoogle Scholar
  2. Hannum, C., Matis, L. A., Schwartz, R. H., and Margoliash, E., 1985, The B10.A mouse B cell response to pigeon cytochrome c is directed against the same area of the protein that is recognized by B10.A T cells in association with the Ek:Eâ la molecule, J. Immunol. 135: 3314–3322.PubMedGoogle Scholar
  3. Lakey, E. K., Margoliash, E., and Pierce, S. K., 1986a, Identification of a peptide binding protein which plays a role in antigen presentation. Proc. Natl. Acad. Sci. USA, in press.Google Scholar
  4. Lakey, E. K., Margoliash, E., Fluoret, G., and Pierce, S. K., 1986b, Peptides related to the antigenic determinant block T cell recognition of the native protein as processed by antigen-presenting cells, Eur. J. Immunol. 16: 721–727.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • E. K. Lakey
    • 1
  • J. A. Smith
    • 2
    • 3
  • E. Margoliash
    • 1
  • S. K. Pierce
    • 1
  1. 1.Department of Biochemistry, Molecular Biology and Cell BiologyNorthwestern UniversityEvanstonUSA
  2. 2.Departments of Molecular Biology and PathologyMassachusettes General HospitalBostonUSA
  3. 3.Department of PathologyHarvard Medical SchoolBostonUSA

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