Animal Models for Affective Disorders

  • William T. McKinney


This chapter begins the second section of the book, which is organized around four case examples, or illustrations, of psychopathological syndromes for which animal models have been proposed. The four clinical syndromes covered are affective disorders, anxiety disorders, schizophrenia, and alcoholism.


Affective Disorder Squirrel Monkey Maternal Separation Inescapable Shock Developmental Psychobiology 
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  1. Abramson, L. Y., Seligman, M. E. P., and Teasdale, J. D. (1978) Learned Helplessness in Humans: Critique and Reformulation. Journal of Abnormal Psychology 87(1): 49–74.PubMedCrossRefGoogle Scholar
  2. Ackerman, S. H., Hofer, M. A., and Weiner, H. (1979) Sleep and Temperature Regulation During Restraint Stress in Rats Is Affected by Prior Maternal Separation. Psychosomatic Medicine 41: 311–319.PubMedGoogle Scholar
  3. Akiskal, H. S., and McKinney, W. T. (1973) Depressive Disorders: Toward a Unified Hypothesis. Science 182: 20–29.PubMedCrossRefGoogle Scholar
  4. Akiskal, H. S., and McKinney, W. T. (1975) Overview of Recent Research in Depression: Integration of Ten Conceptual Models Into a Comprehensive Clinical Frame. Archives of General Psychiatry 32: 285–305.PubMedCrossRefGoogle Scholar
  5. Akiskal, H. S., Bitar, A. H., Puzantian, V. R., Rosenthal, T. L., and Walker, P. W. (1978) The Nosological Status of Neurotic Depression: A Prospective Three to Four Year Examination in Light of the Primary-Secondary and Unipolar-Bipolar Dichotomies. Archives of General Psychiatry 35: 756–766.PubMedCrossRefGoogle Scholar
  6. Anisman, H., and Zacharko, R. M. (1982) Depression: The Predisposing Influence of Stress. Behavioral and Brain Science 5: 89–137.CrossRefGoogle Scholar
  7. Anisman, J., Grimmer, L., Irwin, J., Remington, G., and Sklar, L. S. (1979) Escape Perfor- mance After Inescapable Shock in Select Bred Lines of Mice: Response Maintenance and Catecholamine Act Journal of Comparative and Physiological Psychology 93: 229–241.PubMedCrossRefGoogle Scholar
  8. Anisman, H., Remington, G., and Sklar, L. (1979) Effect of Inescapable Shock on Subsequent Escape Performance: Catecholaminergic and Cholinergic Mediation of Response Initiation and Maintenance. Psychopharmacology 61: 107–124.PubMedCrossRefGoogle Scholar
  9. Anisman, H., Irwin, J., and Sklar, L. (1979) Deficits of Escape Performance Following Catecholaminergic Depletion: Implications for Behavioral Deficits Induced by Uncontrollable Stress. Psychopharmacology 64: 163–170PubMedCrossRefGoogle Scholar
  10. Anisman, H., Pizzino, A. and Sklar, L. S. (1980) Coping With Stress, Norepinephrine Depletion, and Escape Performance. Brain Research 191: 583–588.PubMedCrossRefGoogle Scholar
  11. Anisman, H., Suissa, A., and Sklar, L. S. (1980) Escape Deficits Induced by Uncontrollable Stress: Antagonism by Dopamine and Norepinephrine Agonists. Behavioral and Neural Biology 28: 34–47.PubMedCrossRefGoogle Scholar
  12. Babington, R. G. (1977) The Pharmacology of Kindling. In Animal Models in Psychiatry and Neurology, I. Hanin and E. Usdin (Eds.). Oxford: Pergamon Press.Google Scholar
  13. Beck, A. (1967) Depression: Clinical, Experimental and Theoretical Aspects. New York: Harper and Row.Google Scholar
  14. Binks, S. M., Murchie, J. K., and Greenwood, D. T. (1979) A Reward—Reduction Model of Depression Using Self-Stimulating Rats: An Appraisal Pharmacology, Biochemistry, and Behavior 10: 441–443.PubMedCrossRefGoogle Scholar
  15. Bloom, F. E., Algeri, S., Gropetti, A., Revuelta, A., and Costa, E. (1969) Lesions of Central Norepinephrine Terminals With 6-Hydroxydopamine: Biochemistry and Fine Structure. Science 166: 1284–1286.PubMedCrossRefGoogle Scholar
  16. Bowden, D. M., and McKinney, W. T. (1972) Behavioral Effects of Peer Separation, Isolation, and Reunion On Adolescent Male Rhesus Monkeys. Developmental Psychobiology 5: 353–362.PubMedCrossRefGoogle Scholar
  17. Bowlby, J. (1960a) Separation Anxiety. International Journal of Psychoanalysis 41: 89–113.Google Scholar
  18. Bowlby, J. (1960b) Grief and Mourning in Infancy and Early Childhood. Psychoanalytic Study of the Child 15: 9–52.Google Scholar
  19. Bowlby, J. (1961) Processes of Mourning. International Journal of Psychoanalysis 42: 317–340.PubMedGoogle Scholar
  20. Breese, G. R., and Traylor, T. C. (1970) Effect of 6-Hydroxydopamine on Brain Nor-epinephrine and Dopamine: Evidence for Selective Degeneration of Catecholamine Neurons. Journal of Pharmacology and Experimental Therapeutics 174: 413–420.PubMedGoogle Scholar
  21. Breese, G. P., Smith, R. D., Mueller, R. A., Howard, J. L., Prange, A. J., Lipton, M. A., Young, L. D., McKinney, W. T., and Lewis, J. K. (1973) Induction of Adrenal Catecholamine-Synthesizing Enzymes Following Mother—Infant Separation Nature: New Biology 246: 94–96.CrossRefGoogle Scholar
  22. Brown, G. W., Sklar, R., Harris, T. O., and Birley, J. C. T., (1973a) Life Events and Psychiatric Disorders, Part I: Some Methodological Issues. Psychological Medicine 3: 74–87.CrossRefGoogle Scholar
  23. Brown, G. W., Harris, T. O., and Peto, J. (1973b) Life Events and Psychiatric Disorders, Part II: Nature of Causal Link. Psychological Medicine 3: 159–176.CrossRefGoogle Scholar
  24. Brown, G. W., Nibhrolchain, M., and Harris, T. O. (1979) Psychotic and Neurotic Depression, Part III: Aetiological and Background Factors. Journal of Affective Disorders 1: 195–211.PubMedCrossRefGoogle Scholar
  25. Bunney, W. E., and Davis, J. (1965) Norepinephrine in Depressive Reactions. Archives of General Psychiatry 13: 483–494.PubMedCrossRefGoogle Scholar
  26. Cade, J. F. J. (1949) Lithium Salts in Treatment of Psychotic Excitement. Medical Journal of Australia 2: 349–352.PubMedGoogle Scholar
  27. Cairncross, K. D., Cox, B., Forster, C., and Wren, A. F. (1978) A New Model for the Detection of Antidepressant Drugs: Olfactory Bulbectomy in the Rat Compared With Existing Models. Journal of Pharmacological Methods 1: 131–143.CrossRefGoogle Scholar
  28. Carroll, B. J., Sharp, P. T. (1971) Rubidium and Lithium: Opposite Effects on Amine-Mediated Excitement. Science 172:1355–1357.PubMedCrossRefGoogle Scholar
  29. Coe, C. L., Mendoza, S. P., Smotherman, W. P., Levine, S. (1978) Mother—Infant Attachment in the Squirrel Monkey: Adrenal Response to Separation. Behavioral Biology 22: 256–263.PubMedCrossRefGoogle Scholar
  30. Coe, C., Wiener, S., Rosenberg, L., and Levine, S. (1985) Endocrine and Immune Responses to Separation and Maternal Loss in Nonhuman Primates. In The Biology of Social Attachment, M. Reite and T. Field (Eds.). New York: Academic Press.Google Scholar
  31. Colpaert, F. C., Lenaerts, F. M., Niemegeers, C. J. E., and Janssen, P. A. J. (1975) A Critical Study on RO-4–1284 Antagonism in Mice. Archives Internationales de Pharmacodynamic et de Therapie 215: 40–90.Google Scholar
  32. Coppen, A. J. (1968) Depressed States and Indolealkylamines Advances in Pharmacology #6 New York: Academic Press.Google Scholar
  33. Coppen, A., and Shaw, D. (1963) Mineral Metabolism in Melancholia. British Medical Journal 2: 1439–1444.PubMedCrossRefGoogle Scholar
  34. Coppen, A., Shaw, D., Malleson, S., and Costain, R. (1966) Mineral Metabolism in Mania. British Medical Journal 1: 71–75.PubMedCrossRefGoogle Scholar
  35. Crow, T. J. (1971) The Relationship Between Electrical Self-Stimulation Sites and Catecholamine-Containing Neurones in Rat Mesencephalon. Experientia 27: 662.PubMedCrossRefGoogle Scholar
  36. Davies, C., Sanger, D. J., Steinberg, H., Kiewicz, T., and U’Prichard, D. C. (1974) Lithium and Alpha-methyl-paratyrosine Prevent Manic Activity in Rodents“ Psychopharmacologia 36: 263.PubMedCrossRefGoogle Scholar
  37. Delini-Stula, A., Baumann, P., and Buch, O. (1979) Depression of Exploratory Activity by Clonidine in Rats as a Model for the Detection of Relatively Pre-and Postsynaptic Central Noradrenergic Receptor Selectivity of Alpha-adrenolytic Drugs. Archives of Pharmacology 307: 115–122.PubMedCrossRefGoogle Scholar
  38. Dolhinow, P. (1980) An Experimental Study of Mother Loss in the Indian Langur Monkey (Presbytes entellus). Folia Primatologica 33: 77–128.CrossRefGoogle Scholar
  39. Dorr, M., Joyce, D., Porsolt, R. D., Steinberg, H., Summerfield, A., and Tomkiewicz, M. (1971) Persistence of Dose-Related Behavior in Mice“ Nature 228: 469.Google Scholar
  40. Dubin, R. (1969) Theory Building. New York: The Free Press.Google Scholar
  41. Franklin, K. B. J., and Herberg, L. J. (1977) Non-Contingent Displacement of Catecholamines by Intraventricular Tyramine: Biphasic Dose/Response Effects on Self-Stimulation. Neuropharmacology 16: 53–55.PubMedCrossRefGoogle Scholar
  42. Freis, E. D. (1954) Mental Depression in Hypertensive Patients Treated for Long Periods With Large Doses of Reserpine. New England Journal of Medicine 251: 1006.PubMedCrossRefGoogle Scholar
  43. Garattini, S., and Jori, A. (1967) Interactions Between Imipramine-like Drugs and Reserpine on Body Temperature. In Antidepressant Drugs, S. Garattini and M. N. G. Dukes (Eds.). Amsterdam: Excerpta Medica Foundation, pp. 179–193.Google Scholar
  44. Gardner, R. (1982) Mechanisms in Manic-Depressive Disorder: An Evolutionary Model. Archives of General Psychiatry 39: 1430–1441.CrossRefGoogle Scholar
  45. German, D. C., and Bowden, D. M. (1974) Catecholamine Systems As the Neural Substrate for Intracranial Self-Stimulation: A Hypothesis. Brain Research 73: 381–419.PubMedCrossRefGoogle Scholar
  46. Goodwin, F. K., and Bunney, W. E., (1971) Depressions Following Reserpine-A Reevaluation. Seminars in Psychiatry 3: 435–438.PubMedGoogle Scholar
  47. Gower, A. J., and Marriott, A. S. (1980) The Inhibition of Clonidine-Induced Sedation in the Mouse by Antidepressant Drugs. British Journal of Pharmacology 69: 287–288.Google Scholar
  48. Green, A. R., Head, D. J., Lister, S., and Molyneux, S. (1982) The Effect of Acute and Repeated Desmethylimipramine Administration on Clonidine-Induced Hypoactivity in Rats. British Journal of Pharmacology 75: 33.Google Scholar
  49. Harrison-Read, P. E. (1981) Behavioral Studies With Lithium in Rats: Implications for Animal Models of Mania and Depression. In Neuroendocrine Regulation and Altered Behavior, L. Radhey, and L. Singa (Eds.). New York: Plenum Press, pp. 223–262.CrossRefGoogle Scholar
  50. Hebb, D. O. (1947) Spontaneous Neurosis in Chimpanzees. Psychosomatic Medicine 9: 3–16.PubMedGoogle Scholar
  51. Herberg, L. J., Stephens, D. N., and Franklin, K. B. J. (1976) Catecholamines and SelfStimulation: Evidence Suggesting a Reinforcing Role for Noradrenaline and a Motivat- ing Role for Dopamine. Pharmacology, Biochemistry, and Behavior 4: 575–582.PubMedCrossRefGoogle Scholar
  52. Hinde, R. A., and Davies, L. M. (1972) Changes in Mother—Infant Relationship After Separation in Rhesus Monkeys. Nature 239: 41–42.PubMedCrossRefGoogle Scholar
  53. Hinde, R. A., and Spencer-Booth, Y. (1970) Individual Differences in the Responses of Rhesus Monkeys to a Period of Separation From Their Mothers. Journal of Child Psychology and Psychiatry 11: 159–176.CrossRefGoogle Scholar
  54. Hinde, R. A., and White, L. E. (1974) Dynamics of a Relationship: Rhesus Mother—Infant Ventro-Ventral Contact. Journal of Comparative Physiological Psychology 86: 8–23.CrossRefGoogle Scholar
  55. Hinde, R. A., Spencer-Booth, Y., and Bruce, M. (1966) Effects of 6-Day Maternal Deprivation on Rhesus Monkey Infants. Nature 210: 1021–1023.PubMedCrossRefGoogle Scholar
  56. Hoesman, R. L. (guest editor) (1978) Learned Helplessness as a Model of Depression. Journal of Abnormal Psychology (special issue) Washington, D.C.: American Psychological Association.Google Scholar
  57. Hofer, M. A. (1970) Physiological Responses of Infant Rats to Separation from Their Mothers. Science 168: 871–873.PubMedCrossRefGoogle Scholar
  58. Hofer, M. A. (1975a) Infant Separation Responses and the Maternal Role. Biological Psychiatry 19:149–153.Google Scholar
  59. Hofer, M. A. (1975b) Studies On How Early Separation Produces Behavioral Change in Young Rats. Psychosomatic Medicine 37: 245–264.Google Scholar
  60. Hofer, M. A. (1975c) Survival and Recovery of Physiological Functions After Early Maternal Separation in Young Rats. Physiology and Behavior 15: 475–480.Google Scholar
  61. Hofer, M. A. (1976) The Organization of Sleep and Wakefulness After Maternal Separation in Young Rats. Developmental Psychobiology 9: 189–203.PubMedCrossRefGoogle Scholar
  62. Howard, J. L., Sorok, F. E., and Cooper, B. R. (1981) Empirical Behavioral Models of Depression, With Emphasis on Tetrabenazine Antagonism. In Antidepressants: Neurochemical, Behavioral, and Clinical Perspectives, S. J. Enna, J. B. Malick, E. Richelson (Eds.). New York: Raven Press, pp. 107–120.Google Scholar
  63. Hrdina, P. D, Kulmiz, P. von, and Stretch, R. (1979) Pharmacological Modification of Experimental Depression in Infant Macaques. Psychopharmacology 64: 89–93.PubMedCrossRefGoogle Scholar
  64. Huesmann, L. R., (Ed.) (1978) Journal of Abnormal Psychology 87:(1) Special Issue: Learned Helplessness as a Model of Depression.Google Scholar
  65. Hunt, G. E., Atrens, D. M., and Johnson, G. F. S (1981) The Tetracyclic Antidepressant Mianserin: Evaluation of Its Blockade of Presynaptic Alpha-adrenoreceptors in a Self-Stimulation Model Using Clonidine. European Journal of Pharmacology 70: 59–63.PubMedCrossRefGoogle Scholar
  66. Janowsky, D., El-Yousef, K., Davis, J. M., Hubbard, B., and Sekerke, H. (1972) A Cholinergic-Adrenergic Hypothesis of Mania and Depression. Lancet 2: 632–635.PubMedCrossRefGoogle Scholar
  67. Jensen, G. D., and Tolman, C. W. (1962) Mother—Infant Relationship in the Monkey, Macaca nemestrina: The Effect of Brief Separation and Mother—Infant Specificity. Journal of Comparative Physiological Psychology 55: 131–136.CrossRefGoogle Scholar
  68. Kaplan, J. (1970) The Effects of Separation and Reunion on the Behavior of Mother and Infant Squirrel Monkeys. Developmental Psychobiology 3: 43–52.PubMedCrossRefGoogle Scholar
  69. Katz, R. J. (1981a) Animal Model of Depression: Effects of Electroconvulsive Shock Therapy. Neuroscience and Biobehavioral Reviews 5: 273–279.CrossRefGoogle Scholar
  70. Katz, R. J. (1981b) Animal Models and Human Depressive Disorders. Neuroscience and Biobehavioral Review 5: 231–246.CrossRefGoogle Scholar
  71. Katz, R. J. (1982) Animal Model of Depression: Pharmacological Sensitivity of a Hedonic Effect. Pharmacology, Biochemistry, and Behavior 16: 965–969.PubMedCrossRefGoogle Scholar
  72. Katz, R. J., and Baldrighi, G. (1982) A Further Parametric Study of Imipramine in An Animal Model of Depression. Pharmacology, Biochemistry, and Behavior 16: 969–972.PubMedCrossRefGoogle Scholar
  73. Katz, R. J. and Hersh, S. (1981) Amitryptyline and Scopolamine in an Animal Model of Depression. Neuroscience and Biobehavioral Reviews 5: 265–273.PubMedCrossRefGoogle Scholar
  74. Katz, R. J., Roth, K. A., and Carroll, B. J. (1981) Acute and Chronic Stress Effects on Open Field Activity in the Rat: Implications for a Model of Depression. Neuroscience and Biobehavioral Reviews 5(2): 247–253.PubMedCrossRefGoogle Scholar
  75. Katz, R. J., Roth, K. A., and Schmaltz, K. (1981) Amphetamine and Tranylcypromine in an Animal Model of Depression: Pharmacological Specifity of the Reversal Effect. Neuroscience and Biobehavioral Reviews 5: 259–265.PubMedCrossRefGoogle Scholar
  76. Katz, R. J., Roth, K. A., Mefford, I. A., Carroll, B. J., and Barchas, J. (1982) The Chronically Stressed Rat—A Novel Animal Model of Endogenomorphic Depression. Proceedings of III World Congress of Biological Psychiatry. Stockholm, Sweden.Google Scholar
  77. Kaufman, I. C., and Rosenblum, L. A. (1967a) Depression in Infant Monkeys Separated From their Mothers. Science 155: 1030–1031.CrossRefGoogle Scholar
  78. Kaufman, I. C., and Rosenblum, L. A. (1967b) The Reaction to Separation in Infant Monkeys: Anaclitic Depression and Conservation-Withdrawal. Psychosomatic Medicine 29: 648–675.Google Scholar
  79. Kokkinidis, L., Zacharko, R. M., Predy, P. A. (1980) Post-Amphetamine Depression of Self-Stimulation Responding from the Substantia Nigra: Reversal by Tricyclic Antidepressants. Pharmacology, Biochemistry, and Behavior 13: 379–383.PubMedCrossRefGoogle Scholar
  80. Kraemer, G. W. (1985) Effects of Differences in Early Social Experience on Primate Neurobiological-Behavioral Development. In: The Psychobiology of Attachment. M. Reite, T. Field, (Eds.). New York: Academic Press, pp. 135–161.Google Scholar
  81. Kraemer, G. W., and McKinney, W. T. (1979) Interactions of Pharmacological Agents which Alter Biogenic Amine Metabolism and Depression: An Analysis of Contributing Factors within a Primate Model of Depression. Journal of Affective Disorders 1: 33–54PubMedCrossRefGoogle Scholar
  82. Kraemer, G. W., Lin, D. H., Moran, E. C., and McKinney, W. T. (1980) Effects of Alcohol on the Despair Response to Peer Separation in Rhesus Monkeys. Psychopharmacology 73: 307–310.CrossRefGoogle Scholar
  83. Kraemer, G. W., Ebert, M. H., Lake, R. C., and McKinney, W. T. (1984) Cerebrospinal Fluid Measures of Neurotransmitter Changes Associated with Pharmacological Alteration of the Despair Response to Social Separation in Rhesus Monkeys. Psychiatry Research 11: 303–315.PubMedCrossRefGoogle Scholar
  84. Lapin, I., and Oxenkrug, G. (1969) Intensification of the Central Serotonergic Process As a Possible Determinant of Thymoleptic Effect. Lancet 1: 132–136.PubMedCrossRefGoogle Scholar
  85. Levine, S., Coe, C. L., Smotherman, W. P. (1978) Prolonged Cortisol Elevation in the Infant Squirrel Monkey After Reunion With Mother. Physiology and Behavior 20: 7–10.PubMedCrossRefGoogle Scholar
  86. Lewis, J. K., McKinney, W. T., Young L. D., Kraemer, G. W. (1976) Mother–infant Separation in Rhesus Monkeys as a Model of Human Depression: A Reconsideration. Archives of General Psychiatry 33:699–705.PubMedCrossRefGoogle Scholar
  87. Liebman, J. M., Segal, D. S. (1976) Lithium Differentially Antagonises Self-Stimulation Facilitated by Morphine and (+)Amphetamine. Nature 260(5547):161–163.PubMedCrossRefGoogle Scholar
  88. Limieux, G., Davignon, A., Genst, J. (1956) Depressive States During Rauwolfia Therapy for Arterial Hypertension“ Canadian Medical Assn. Journal 74: 522.Google Scholar
  89. Lynch, M. A., and Leonard, B. E. (1978) Effect of Chronic Amphetamine Administration on the Behavior of Rats in the Open Field Apparatus: Reversal of Post-Withdrawal Depression by Two Antidepressants. J.Pharmacy and Pharmacology 30: 798–799.CrossRefGoogle Scholar
  90. MaLer, S. F. (1984) Learned Helplessness and Animal Models of Depression. Progress in Neuropsychopharmacology and Biological Psychiatry. Google Scholar
  91. Mamelak, M. (1978) An Amphetamine Model of Manic Depressive Illness. International Pharmacopsychiatry 13: 193–208.PubMedGoogle Scholar
  92. Maxim, P. E. (1980) Rewarding Brain Stimulation and the Peer—Infant Separation Syndrome. Physiology and Behavior 25: 53–61.PubMedCrossRefGoogle Scholar
  93. McKinney, W. T., Suomi, S. J., and Harlow, H. F. (1972) Repetitive Peer Separations of Juvenile-age Rhesus Monkeys. Archives of General Psychiatry 27: 200–203.PubMedCrossRefGoogle Scholar
  94. Mineka, S., and Suomi, S. J. (1978) Social Separation in Monkeys. Psychological Bulletin 85: 1376–1400.PubMedCrossRefGoogle Scholar
  95. Moller-Nielsen, I. (1980) Tricyclic Antidepressants: General Pharmacology. In Psychotropic Agents. Part I. Antipsychotics and Antidepressants, F. Hoffmeister and G. Stille (Eds.). Berlin: Springer Verlag, pp. 399–414.Google Scholar
  96. Murphy, D. L. (1977) Animal Models for Mania. In Animal Models in Psychiatry and Neu- rology, I. Hanin and E. Usdin (Eds.). New York: Pergamon Press, pp. 211–223.Google Scholar
  97. Overmier, J. B., Seligman, M. E. (1967) Effects of inescapable Shock upon Subsequent Escape and Avoidance Responding. Journal of Comparative and Physiological Psychology 63:28–33.PubMedCrossRefGoogle Scholar
  98. Panksepp, J., Herman, B., Conner, R., Bishop, P., and Scott, J. P. (1978) The Biology of Social Attachments: Opiates Alleviate Separation Distress. Biological Psychiatry 13: 607–618.PubMedGoogle Scholar
  99. Panksepp, J., Vilberg, T., Bean, N. J., Coy, D. H., and Kastin, A. J. (1978) Reduction of Distress Vocalization in Chicks by Opiate-like Peptides. Brain Research Bulletin 3: 663667.Google Scholar
  100. Paykel, E. S. (1974) Recent Life Events and Clinical Depression. In Life Stress and Illness, E. K. Gunderson and R. H. Rahe (Eds.). pp. 134–163. Charles C. Thomas: Springfield, IL.Google Scholar
  101. Paykel, E. S. (1978) Contribution of Life Events to Causation of Psychiatric Illness. Psychological Medicine 8: 245–253.PubMedCrossRefGoogle Scholar
  102. Paykel, E. S. (1979a) Causal Relationships Between Clinical Depression and Life Events. In Stress and Mental Disorder J. E. Barrett (Ed.). New York: Raven Press.Google Scholar
  103. Paykel, E. S. (1979b) Predictors of Treatment Response. In Psychopharmacology of Affective Disorders, E. S. Paykel and A. Coppen (Eds.). Oxford: Oxford University Press, pp. 193–200.Google Scholar
  104. Paykel, E. S. (1982a) Life Events and Early Environment. In Handbook of Affective Disorders, E. S. Paykel (Ed.). New York: Churchill Livingstone, pp. 146–161.Google Scholar
  105. Paykel, E. S. (1982b) Recent Life Events. Proceedings of Dahlem Workshop on The Origins of Depression: Current Concepts and Approaches, October 31-November 5, 1982.Google Scholar
  106. Pettijohn, T. F. (1979) Attachment and Separation Distress in the Infant Guinea Pig. Developmental Psychobiology 12: 73–81.PubMedCrossRefGoogle Scholar
  107. Pettijohn, T. F., Wong, T. W., Ebert, P. D., and Scott, J. D. (1977) Alleviation of Separation Distress in Three Breeds of Young Dogs. Developmental Psychobiogy 10: 373–381.CrossRefGoogle Scholar
  108. Petty, F., and Sherman, A. D. (1980) Regional Aspects of the Prevention of Learned Helplessness By Desipramine. Life Sciences 26: 1447–1452.PubMedCrossRefGoogle Scholar
  109. Petty, F., and Sherman, A. D. (1981a) GABAergic Modulation of Learned Helplessness. Pharmacology, Biochemistry, and Behavior 15: 567–570.CrossRefGoogle Scholar
  110. Petty, F., and Sherman, A. D. (1981b) A Pharmacologically Pertinent Animal Model of Mania. Journal of Affective Disorders 3: 381–387.CrossRefGoogle Scholar
  111. Porsolt, R. D. (1981) Behavioral Despair. In Antidepressants: Neurochemical, Behavioral, and Clinical Perspectives, S. J. Enna, J. B. Malick, E. Richelson (Eds.). New York: Raven Press, pp. 121–139.Google Scholar
  112. Porsolt, R. D. (1982) Pharmacological Models of Depression. Proceedings of Dahlem Conference on The Origins of Depression: Current Concepts and Approaches, October 31-November 5, 1982.Google Scholar
  113. Porsolt, R. D., Anton, G., Blavel, N., and Jalfre, M. (1977) Depression: A New Animal Model Sensitive to Antidepressant Treatments. Nature 21: 730–732.CrossRefGoogle Scholar
  114. Prange, A. (1964) The Pharmacology and Biochemistry of Depression. Diseases of the Nervous System 25: 217–221.PubMedGoogle Scholar
  115. Price, J. (1967) The Dominance Hierarchy and The Evolution of Mental Illness. Lancet 2: 243–246.CrossRefGoogle Scholar
  116. Raleigh, M., McGuire, M. T., Brammer, G. L., and Yuwiler, A. (1984) Social and Environmental Influences on Blood Serotonin Concentrations in Monkeys. Archives of General Psychiatry 41: 405–410.PubMedCrossRefGoogle Scholar
  117. Randrup, A., and Munkvard, I. (1967) Stereotyped Activities Produced by Amphetamine in Several Animal Species and Man. Psychopharmacology 11: 300.CrossRefGoogle Scholar
  118. Reite, M. (1977) Maternal Separation in Monkey Infants: A Model of Depression. In Animal Models in Psychiatry and Neurology I. Hanin and E. Usdin (Eds.). New York: Pergamon Press, pp. 127–139.Google Scholar
  119. Reite, M., and Short, R. (1977) Nocturnal Sleep in Isolation Reared Monkeys: Evidence for Environmental Independence. Developmental Psychobiology 10: 555–561.PubMedCrossRefGoogle Scholar
  120. Reite, M., and Short, R. A. (1978) Nocturnal Sleep in Separated Monkey Infants. Archives of General Psychiatry 35: 1247–1253.CrossRefGoogle Scholar
  121. Reite, M., Kaufman, I. C., Pauley, J. D., and Stynes, A. J. (1974) Depression in Infant Monkeys: Physiological Correlates. Psychosomatic Medicine 36: 363–367.PubMedGoogle Scholar
  122. Reite, M., Stynes, A. J., Vaughn, L., Pauley, J. D., and Short, R. A. (1976) Sleep in Infant Monkeys: Normal Values and Behavioral Correlates. Physiology and Behavior 16: 245–251.PubMedCrossRefGoogle Scholar
  123. Reite, M., Short, R., Kaufman, I. C., Stynes, M. J., and Pauley, J. D. (1978) Heart Rate and Body Temperature in Separated Monkey Infants. Biological Psychiatry 13: 91–105.PubMedGoogle Scholar
  124. Reite, M., Harbeck, R., and Hoffman, A. (1981) Altered Cellular Immune Response Following Peer Separation. Life Sciences 29: 1133–1136.PubMedCrossRefGoogle Scholar
  125. Reite, M., Short, R., Seiler, C., and Pauley, J. D. (1981) Attachment, Loss, and Depression. Journal of Child Psychology and Psychiatry 22: 141–169.PubMedCrossRefGoogle Scholar
  126. Reite, M., Seiler, C., Crowley, T. J., Hydinger-Macdonald, M., and Short, R. (1982) Circadian Rhythm Changes Following Maternal Separation. Chronobiologia 9: 1–11.PubMedGoogle Scholar
  127. Richter, C. P. (1957) On The Phenomenon of Sudden Death in Animals and Man. Psychosomatic Medicine 19: 191–197.PubMedGoogle Scholar
  128. Robertson, J., and Bowlby, J. (1952) Responses of Young Children to Separation From Their Mothers. Cours du Centre International de l’Enfance 2: 131–142.Google Scholar
  129. Robertson, J., and Robertson, J. (1971) Young Children in Brief Separation. Psychoanalytic Study of the Child 26: 264–315.PubMedGoogle Scholar
  130. Robson, R. D., Antonaccio, M. J., Saelens, J. K., and Liebman, J. (1978) Antagonism by Mianserin and Classical Alpha-adrenoreceptor Blocking Drugs of Some Cardiovascular and Behavioral Effects of Clonidine. European Journal of Pharmacology 47: 431–442.PubMedCrossRefGoogle Scholar
  131. Rosenblum, L. A., and Kaufman, I. C. (1968) Variations in Infant Developement and Response to Maternal Loss in Monkeys. American Journal of Orthopsychiatry 83: 418426.Google Scholar
  132. Rosenthal, T. L., Akiskal, H. S., Scott-Strauss, A., Rosenthal, R. H., and David, M. (1981) Familial and Developmental Factors in Characterological Depressions. Journal of Affective Disorders 3: 183–192.PubMedCrossRefGoogle Scholar
  133. Roth, K. A., and Katz, R. J. (1981) Further Studies on a Novel Animal Model of Depression: Therapeutic Effects of a Tricyclic Antidepressant. Neuroscience and Biobehavioral Reviews 5: 253–259.PubMedCrossRefGoogle Scholar
  134. Rushton, R., and Steinberg, H. (1966) Mutual potentiation of Amphetamine and Amylobarbitone Measured by Activity in Rats. British Journal of Pharmacology 21: 295.Google Scholar
  135. Rushton, R., and Steinberg, H. (1966) Combined Effects of Chlordiazepoxide and Dexamphetamine on Activity of Rats in an Unfamiliar Environment. Nature 211: 1312.PubMedCrossRefGoogle Scholar
  136. Sanghvi, I. S., and Gershon, S. (1977) Animal Test Models for Prediction of Clinical Antidepressant Activity. In Animal Models in Psychiatry and Neurology, I. Hanin and E. Usdin (Eds.). Oxford: Pergamon Press, pp. 157–171.Google Scholar
  137. Scherschlicht, R., Polc, P., Schneeberger, J., Steiner, M., and Haefely, W. (1982) Selective Suppression of Rapid Eye Movement Sleep (REMS) in Cats by Typical and Atypical Antidepressants. In Typical and Atypical Antidepressants: Molecular Mechanisms, E. Costa, and G. Racagni (Eds.). New York: Raven Press, pp. 359–364.Google Scholar
  138. Schildkraut, J. (1965) Catecholamine Hypothesis of Affective Disorders. American Journal of Psychiatry 122: 509–522.PubMedGoogle Scholar
  139. Seay, B., Hansen, E., and Harlow, H. F. (1962) Mother—Infant Separation in Monkeys. Journal of Child Psychology and Psychiatry 3: 123–132.PubMedCrossRefGoogle Scholar
  140. Seligman, M. E. P., and Maier, S. F. (1967) Failure to Escape Traumatic Shock. Journal of Experimental Psychology 74: 1–9.PubMedCrossRefGoogle Scholar
  141. Seltzer, V., and Tongre, S. R. (1975) Methylamphetamine Withdrawal As a Model for the Depressive State: Antagonism of Post-Amphetamine Depression by Imipramine. Journal of Pharmacy and Pharmacology 27: 16P.Google Scholar
  142. Senay, E. C. (1966) Toward an Animal Model of Depression: A Study of Separation Behavior in Dogs. Journal of Psychiatric Research 4: 65–71.PubMedCrossRefGoogle Scholar
  143. Sherman, A. D., and Petty, F. (1980) Neurochemical Basis of the Action of Antidepressants on Learned helplessness. Behavioral and Neural Biology 30: 119–134.PubMedCrossRefGoogle Scholar
  144. Sherman, A. D., and Petty, F. (1982) Additivity of Neurochemical Changes in Learned Helplessness and Imipramine. Behavioral and Neural Biology 35: 344–353.PubMedCrossRefGoogle Scholar
  145. Smotherman, W. P., Hunt, L. E., McGinnis, L. M., and Levine, S. (1979) Mother—Infant Separation in Group Living Rhesus Macaques: A Hormonal Analysis. Developmental Psychobiology 12: 211–217.Google Scholar
  146. Solomon, R. L., Corbit, J. D. (1974) An Opponent-Process Theory of Motivation: I. Temporal Dynamics of Affect. Psychological Review 81:119–145.PubMedCrossRefGoogle Scholar
  147. Spitz, R. A. (1946) Anaclitic Depression: An Inquiry into the Genesis of Psychiatric Conditions in Early Childhood, II. Psychoanalytic Study of the Child 2: 313–347.PubMedGoogle Scholar
  148. Stach, R., Lazarova, M. B., and Kacz, D. (1980) The Effects of Antidepressant Drugs on the Seizures Kindled From the Rabbit Amygdala. Polish Journal of Pharmacology and Pharmacy 32: 505–512.PubMedGoogle Scholar
  149. Steinberg, H. (1973) Animal Models for Behavioral and Biobehavioral Studies on the Effects of Lithium Salts. Biochemical Society Transactions 1: 38.Google Scholar
  150. Steinberg, H., and Tomkiewicz, M. (1970) Animal Behavior Models in Psychopharmacology. In Chemical Influences On Behaviors, R. Porter and J. Birch (Eds.). CIBA Foundation Study Group, 35: 199; Churchill: London.Google Scholar
  151. Suomi, S. J. (1976) Factors Affecting Responses to Social Separation in Rhesus Monkeys. In Animal Models in Human Psychobiology, G. Serban, and A. Kling (Eds.). New York: Plenum Press, pp. 9–26.CrossRefGoogle Scholar
  152. Suomi, S. J., Harlow, H. F., and Domek, C. J. (1970) Effect of Repetitive Infant—Infant Separation of Young Monkeys. Journal of Abnormal Psychology 76: 161–172.PubMedCrossRefGoogle Scholar
  153. Suomi, S. J., Collins, M. L., and Harlow, H. F. (1973) Effects of Permanent Separation from Mother on Infant Monkeys. Developmental Psychobiology 9: 376–384.Google Scholar
  154. Suomi, S. J., Eisele, C. D., Grady, S. A., and Harlow, H. F. (1975) Depressive Behavior in Adult Monkeys Following Separation from Family Environment. Journal of Abnormal Psychology 84: 576–578.PubMedCrossRefGoogle Scholar
  155. Suomi, S. J., Coffins, M. L., Harlow, H. F., and Ruppenthal, G. C. (1976) Effects of Maternal and Peer Separations on Young Monkeys. Journal of Child Psychology and Psychiatry 17: 101–112.PubMedCrossRefGoogle Scholar
  156. Suomi, S. J., Seaman, S. F., Lewis, J. K., Delizio, R. D., and McKinney, W. T. (1978) Effects of Imipramine Treatment of Separation Induced Social Disorders in Rhesus Monkeys. Archives of General Psychiatry 35: 321–325.PubMedCrossRefGoogle Scholar
  157. Takahashi, R., Nagayama, H., Kido, A., and Morita, T. (1974) An Animal Model of Depression. Biological Psychiatry 9: 191–204.PubMedGoogle Scholar
  158. Tinkelpaugh, O. L. (1928) The Self-Mutilation of a Male Macaque Rhesus Monkey. Journal of Mammalogy 9: 293–300.CrossRefGoogle Scholar
  159. Tomkiewicz, M., Steinberg, H. (1972) Proceedings: Amylobarbitone Abolishes Social Dominance Hierarchies in Laboratory Rats. British Journal of Pharmacology 44:351P.Google Scholar
  160. Van Riezen, H., Schnieden, H., and Wren, A. F. (1977) Olfactory Bulb Ablation in the Rat: Behavioral Changes and their Reversal by Antidepressant Drugs. British Journal of Pharmacology 60: 521–528.PubMedGoogle Scholar
  161. Vogel, J. R. (1975) Antidepressants and Mouse Killing (Muricide) Behavior. In Industrial Pharmacology: Volume 2: Antidepressants,S. Fielding, and H. Lal (Eds.). New York: Futura, pp. 99–112.Google Scholar
  162. Vogt, J. L., and Levine, S. (1980) Response of Mother and Infant Squirrel Monkeys to Separation and Disturbance Physiology and Behavior 24: 829–832.PubMedCrossRefGoogle Scholar
  163. Von Voigtlander, P. F., Von Triezenberg, H. G., Losey, E. G. (1978) Interactions between Clonidine and Antidepressant Drugs: A Method for Identifying Antidepressant-like Agents. Neuropharmacology 17: 375–381.CrossRefGoogle Scholar
  164. Wauquier, A. (1976) Brain Stimulation Reward. New York: American Elsevier, pp. 123–171.Google Scholar
  165. Weiss, J. M., and Goodman, P. A. (1984) Neurochemical Mechanisms Underlying StressInduced Depression. In Stress and Coping (Vol. 1), P. McCabe and N. Schneiderman (Eds.). Hillsdale, New Jersey: Lawrence-Erlbaum.Google Scholar
  166. Weiss, J. M., Glazer, H. I., Pohorecky, L. A. (1976) Coping Behavior and Neurochemical Changes: An Alternative Explanation for the Original Learned Helplessness Experiments. In Animal Models in Human Psychobiology, G. Serban and A. Kling (Eds.). New York: Plenum, pp. 141–173.CrossRefGoogle Scholar
  167. Weiss, J. M., Glazer, H. I., Pohorecky, L. A., Bailey, W. H., and Schneider, L. H. (1979) Coping Behavior and Stress-Induced Behavioral Depression: Studies of the Role of Brain Catecholamines. In The Psychobiology of the Depressive Disorders, Richard A. Depue (ed.). New York: Academic Press, pp. 125–160.Google Scholar
  168. Weiss, J. M., Goodman, P., Ambrose, M. J., Webster, A., and Hoffman, L. J. (1984) Neurochemical Basis of Behavioral Depression. In Advances in Behavioral Medicine (Vol. 1), E. Katkin and S. Manuck (Eds.). Greenwich, Connecticut: JAI Press.Google Scholar
  169. Whybrow, P., and Mendels, J. (1969) Toward a Biology of Depression: Some Suggestions from Neurophysiology. American Journal of Psychiatry 125: 45–54.Google Scholar
  170. Whybrow, P., and Parlatore, A. (1973) Melancholia: A Model in Madness: A Discussion of Recent Psychobiologic Research Into Depressive Illness. International Journal of Psychiatry in Medicine 4: 351–378.PubMedCrossRefGoogle Scholar
  171. Whybrow, P., Akiskal, H., and McKinney, W. (1984) Mood Disorders: Toward a New Psychobiology. New York: Plenum.Google Scholar
  172. Yerkes, R. M., and Yerkes, A. W. (1929) The Great Apes. New Haven: Yale Universities Press.Google Scholar

Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • William T. McKinney
    • 1
  1. 1.University of Wisconsin Medical SchoolMadisonUSA

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