Philosophical Basis for the Development of Animal Models for Psychiatric Illnesses

  • William T. McKinney


This may be the most important chapter in this book. Though there is considerable activity and excitement in the animal modeling, or what might be called “comparative psychiatry,” area, there is no conceptual framework for guiding the development of this field. The relevant basic sciences are scattered and have not been brought together in any organized manner as they relate to the development of animal models. We do not know how to evaluate proposed animal models for a given disorder or even how to conceptualize the roles for animal models as part of a spectrum of approaches in psychopathology research.


Psychiatric Illness Stereotypic Behavior Empirical Validity Animal Preparation Philosophical Basis 


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  1. Abramson, L. Y., and Seligman, M. (1977) Psychopathology: Experimental Methods. San Francisco: Freeman.Google Scholar
  2. Akiskal, H. S., and McKinney, W. T. (1973) Depressive Disorders: Toward a Unified Hypothesis” Science 182: 20–29.PubMedCrossRefGoogle Scholar
  3. Akiskal, H. S., and McKinney, W. T. (1975) Overview of Recent Research in Depression: Integration of Ten Conceptual Models Into a Comprehensive Clinical Frame. Archives of General Psychiatry 32: 285–305.PubMedCrossRefGoogle Scholar
  4. Eibl-Eibesfeldt (1983) The Comparative Approach in Human Ethology. In Comparing Behavior: Studying Man Studying Animals, D. W. Rajecki (Ed.). Hillsdale, New Jersey: Lawrence Erlbaum.Google Scholar
  5. Grant, E. C. (1965) The Contribution of Ethology to Child Psychiatry. In Modern Perspectives in Child Psychiatry, J. G. Howells (Ed.). Edinburgh: Oliver and Boyd.Google Scholar
  6. Hamburg, D. A. (1968) Evolution of Emotional Responses: Evidence From Recent Research on Nonhuman Primates in Science and Psychoanalysis: Vol. 12, Animal and Human, J. H. Masserman (Ed.). New York: Grune and Stratton.Google Scholar
  7. Hanin, I., and Usdin, E. (Eds.) (1977) Animal Models in Psychiatry and Neurology. Oxford: Pergamon Press.Google Scholar
  8. Hinde, R. A. (1972) Social Behavior and Its Development in Subhuman Primates. Eugene, Oregon: Oregon State System of Higher Education.Google Scholar
  9. Hutt, S. J. (1970) The Role of Behavior Studies in Psychiatry: an Ethological Viewpoint. In Behavior Studies in Psychiatry, S. J. Hutt and C. Hutt (Eds.). New York: Pergamon Press.Google Scholar
  10. Ingle, D., and Shein, H. M. (Eds.) (1975) Model systems in Biological Psychiatry. Cambridge, Massachusetts: MIT Press.Google Scholar
  11. Jones, I. H. (1971) Ethology and Psychiatry. Australian and New Zealand Journal of Psychiatry 5: 258–263.PubMedCrossRefGoogle Scholar
  12. Kaufman, I. C., and Rosenblum, L. A. (1967a) The Reaction to Separation in Infant Monkeys: Anaclitic Depression and Conservation Withdrawal. Psychosomatic Medicine 29: 648–675.PubMedGoogle Scholar
  13. Kaufman, I. C., and Rosenblum, L. A. (1967b) Depression in Infant Monkeys Separated From Their Mothers. Science 155: 1030–1031.PubMedCrossRefGoogle Scholar
  14. Klein, D. (1974) Endogenomorphic Depression: A Conceptual and Terminological Revision. Archives of General Psychiatry 31: 447–454.PubMedCrossRefGoogle Scholar
  15. Kormetsky, C. (1977) Animal Models: Promises and Problems. In Animal Models in Psychiatry and Neurology, I. Hanin and E. Usdin (Eds.). New York: Pergamon.Google Scholar
  16. Kraemer, S. (1977) Ethological Contributions to the Medical and Behavioral Sciences. In The Future of Animals, Cells, Models, and Systems in Research, Development, Education, and Testing Washington, D.C.: National Academy of Sciences.Google Scholar
  17. Lehrman, D. S. (1974) Can Psychiatrists Use Ethology. In Ethology and Psychiatry, N. F. White (Ed.). Toronto: University of Toronto Press.Google Scholar
  18. Levy, D. M. (1952) Animal Psychology in its Relation to Psychiatry. In Dynamic Psychiatry Franz Alexander and Helen Ross (Eds.). Chicago: University of Chicago Press.Google Scholar
  19. McGuire, M. T., and Fairbanks, L. A. (1977) Ethology: Psychiatry’s Bridge to Behavior. In Ethological Psychiatry, M. T. McGuire and L. A. Fairbanks (Eds.). New York: Grune and Stratton.Google Scholar
  20. McKinney, W. T., and Bunney, W. E. (1969) Animal Model of Depression, Review of Evidence: Implications for Research. Archives of General Psychiatry 21: 240–248.PubMedCrossRefGoogle Scholar
  21. Mitchell, G. D. (1970) Abnormal Behavior in Primates. In Primate Behavior, L. Rosenblum (Ed.). New York: Academic Press.Google Scholar
  22. Rosenblum, L. A., and Kaufman, I. C. (1968) Variations in Infant Development and Response to Maternal Loss in Monkeys. American Journal of Orthopsychiatry 83: 418–426.Google Scholar
  23. Serban, G., and Kling, A. (Eds.) (1976) Animal Models in Human Psychobiology. New York: Plenum.Google Scholar
  24. Startsev, V. G. (1976) Primate Models of Human Neurogenic Disorders (English translation edited by D. M. Bowden). Hillsdale, New Jersey: Lawrence Erlbaum.Google Scholar
  25. Suomi, S. J., and Immelman, K. (1983) On the Process and Product of Cross- Species Generalization. In Comparing Behavior: Studying Man Studying Animals D. W. Rajecki (Ed.). Hillsdale, New Jersey: Lawrence Erlbaum.Google Scholar
  26. Whybrow, P., Akiskal, H., McKinney, W. (1984) Mood Disorders: Toward a New Psychobiology. Plenum: New York.Google Scholar
  27. Whybrow, P., and Parlatore, A. (1973) Melancholia: A Model in Madness: A Discussion of Recent Psychobiologic Research Into Depressive Illness. International Journal of Psychiatry in Medicine 4: 351–378.PubMedCrossRefGoogle Scholar
  28. Wickler, W. (1965) Tiber den taxonomischen Wert Homologer Verhaltensmerkmale. Naturwissenschaften 52: 44–444.CrossRefGoogle Scholar
  29. Zegans, L. S. (1967) An Appraisal of Ethological Contributions to Psychiatric Theory and Research. American Journal of Psychiatry 124: 729–739.PubMedGoogle Scholar
  30. Zubin, J., and Hunt, H. F. (Eds.) (1967) Comparative Psychopathology: Animal and Human. New York: Grune and Stratton.Google Scholar

Copyright information

© Plenum Publishing Corporation 1988

Authors and Affiliations

  • William T. McKinney
    • 1
  1. 1.University of Wisconsin Medical SchoolMadisonUSA

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