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Opioids, Behavior, and Learning in Mammalian Development

  • Priscilla Kehoe
Part of the Handbook of Behavioral Neurobiology book series (HBNE, volume 9)

Abstract

Endogenous opioid peptides and their binding sites reside within systems found in the brain and spinal cord, the pituitary, the adrenal medulla, and the autonomic nervous system (Akil, Watson, Young, Lewis, Khachaturian, and Walker, 1984; Basbaum and Fields, 1984; Khachaturian, Lewis, Schafer, and Watson, 1985). These systems seem to be involved in the modulation of physiological and behavioral responsivity to endogenous and environmental demands. Morley (1981) suggested that the discovery of the opioid systems and their diverse functions concerning stress extends Cannon’s flight-or-fight (1929) concept and Selye’s theory of general adaptation (1976). Specifically, opioid physiology embraces thermal, cardiac, respiratory, miotic, and immune functions, among others (see Watson, Akil, Khachaturian, Young, and Lewis, 1984, for a review). Changes in opioid physiology and in derivative behaviors actually occur during stressful or emergency situations. For example, rats confronted with a novel experience and stressful handling demonstrate increased body temperature, which is naloxone-reversible and is correlated with increased beta-endorphin activity (Blasig, Holit, Bauerle, and Herz, 1978; Clark, 1979). Thermal fluctuations may thus reflect opioid preparation to meet environmental demands. Furthermore, evidence for opioid involvement in stress-induced enhancement of tumor growth has been found (Lewis, Shovit, Ternor, Nelson, Gale and Liebeskind, 1983).

Keywords

Pain Sensitivity Opioid System Endogenous Opioid Opiate Receptor Opioid Antagonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Akil, H., and Watson, S. J.: Beta-endorphin and biosynthetically related peptides in the central nervous system. In L. Iverson, S. D. Iverson, and S. Snyder (Eds.), Handbood of psychopharmacology, Vol. 16. New York: Plenum Press, 1983.Google Scholar
  2. Akil, H., Madden, J., Patrick, R. L., and Barchas, J. D.: Stress-induced increase in endogenous opiate peptides: Concurrent analgesia and its partial reversal by naloxone. In H. W. Kosterlitz (Ed)., Opiates and endogenous opioid peptides. Amsterdam: Elsevier, 1976a.Google Scholar
  3. Akil, H., Mayer, D. J., and Liebeskind, J. C.: Antagonism of stimulation-produced analgesia by naloxone, a narcotic antagonist. Science 1976b, 191, 961–962.PubMedGoogle Scholar
  4. Akil, H. Watson, S. J., Young, E., Liewis, M. E., Khachaturian, H., and Walker, J. M.: Endogenous opioids: Biology and function. Annual Review of Neuroscience, 1984, 7, 223–255.PubMedGoogle Scholar
  5. Alberts, J. R.: Ontogeny of olfaction: Reciprocal roles of senation and behavior in the development of perception. In R. N. Aslin, J. R. Alberts, and M. R. Petersen (Eds.), The development of perception: Psychobiological perspectives. New York: Academic Press, 1981.Google Scholar
  6. Allin, J. T., and Banks, E. M.: Functional aspects of ultrasound production by infant albino rats (Rattus norvegicus). Animal Behavior, 1972, 20, 175–185.Google Scholar
  7. Amir, S., and Amit, Z.: Endogenous opioid ligands may mediate stress-induced changes in the affective properties of pain related behavior in rats. Life Science, 1975, 23, 1143–1152.Google Scholar
  8. Amir, S., and Bernstein, M.: Endogenous opioids interact in stress-induced hyperglycemia in mice. Physiology and Behavior, 1982, 28, 575–577.PubMedGoogle Scholar
  9. Amir, S., Brown, Z. W., and Amit, Z.: The role of endorphins in stress: Evidence and speculations. Neuroscience Biobehavioral Reviews, 1980 4, 77–80.Google Scholar
  10. Arbilla, S., and Langer, S. Z.: Morphine and beta-endorphin inhibit release of noradrenaline from cerebral cortex but not of dopamine from rat striatum. Nature, 1978, 271, 559–560.PubMedGoogle Scholar
  11. Auguy-Valette, A., Cros, J., Gouarderes, C., Gout, R., and Pontonnier, G.: Morphine analgesia and cerebral opiate receptors: A developmental study. British Journal of Pharmacology, 1978 63, 303–308.PubMedGoogle Scholar
  12. Bardo, M. T., and Hughes, R. A.: Exposure to a nonfunctional hot plate as a factor in the assessment of morphine-induced analgesia and analgesic tolerance in rats. Pharmacology Biochemistry Behavior, 1979, 10, 481–485.Google Scholar
  13. Bardo, M. T., Bhatnagar, R. K., and Gebhart, G. F.: Differential effects of chronic morphine and naloxone on opiate receptors, monoanimes, and morphine-induced behaviors in preweanling rats. Developmental Brain Research, 1982, 4, 139–147.Google Scholar
  14. Barr, G. A. Paredes, S. W., Erickson, K. L., and Zukin, R. S.: Evidence for K-receptor mediated analgesia in the developing rat. Society for Neuroscience Abstracts, 1983, 9, 328.Google Scholar
  15. Basbaum, A. I., and Fields, H. L.: Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry. Annual Review of Neuroscience, 1984, 7, 309–338.PubMedGoogle Scholar
  16. Bayon, A., Shoemaker, W. J., Bloom F. E., Mauss, A., and Guillemin, R.: Perinatal development of the endorphin-and enkephalin-containing systems in the rat brain. Brain Research, 1979, 179, 93–101.PubMedGoogle Scholar
  17. Belluzzi, J. D., and Stein, L: Enkephalin may mediate euphoria and drive reduction reward. Nature, 1977, 266, 556–558.PubMedGoogle Scholar
  18. Blasig, J., Holit, V., Bauerle, U., and Herz, A.: Involvement of endorphins in emotional hyperthermia of rats. Life Sciences, 1978, 23, 2525–2532.PubMedGoogle Scholar
  19. Blass, E. M., Fitzgerald, E., Synder E., and Kehoe, P.: Sucrose or milk inhibit distress vocalizations in 10-day-old rats. Society of euroscience Abstracts, 11, 1985, 912.Google Scholar
  20. Bloom, F., Battenberg, E., Rossier, J., Ling, N., and Guillemin, R.: Neurons containing B-endorphin in rat brain exist separately from those containing enkephalin. Immunocytochemical studies. Proceedings of the National Academy of Sciences, 1978, 75, 1591–1595.Google Scholar
  21. Bodnar, R. J.: Neuropharmacological and neuroendocrine substrates of stress-induced analgesia. Presentation at the New York Academy of Sciences Conference on Stress-Induced Analgesia, New York, 1985.Google Scholar
  22. Bolles, R. C., and Fanselow, M. S.: A perceptual defensive-recuperative model of fear and pain. Behavioral and Brain Science, 1980, 3, 291–323.Google Scholar
  23. Brake, S. C.: Suckling infant rats learn a preference for a novel olfactory stimulus paired with milk delivery. Science, 1981, 211, 506–508.PubMedGoogle Scholar
  24. Bugnon, C.: Etude des neurones immunoreactifs à un immunserum anti-b-endorphine chez le foetus humain et l’homme adult. Colloque de Neuroendocrinologie Expt., Geneve, 1978.Google Scholar
  25. Cannon, W. B.: Organization for physiological homeostasis. Physiological Reviews, 1929, 9, 399–431.Google Scholar
  26. Carr, K. D., and Simon E. J.: The role of opioids in feeding and reward elicited by lateral hypothalmic electrical stimulation. Life Sciences, 1983, 33, 563–566.PubMedGoogle Scholar
  27. Caza, P. A., and Spear, L. P.: Ontogenesis of morphine-induced behavior in the rat. Pharmacology Biochemistry Behavior, 1980, 13, 45–50.Google Scholar
  28. Chance, W. T.: Autoanalgesia: Opiate and non-opiate mechanisms. Neuroscience Biobehavioral Reviews, 1980, 4, 55–67.Google Scholar
  29. Chance, W. T., White, A. C., Krynock, G. M., and Rosecrans, J. A.: Autoanalgesia: Behaviorally activated antinociception. European Journal of Pharmacology, 1977, 44, 283–284.PubMedGoogle Scholar
  30. Chang, K. J., and Cuatrecasas, P.: Multiple opiate receptors: Enkephalins and morphine bind to recaptors of different specificity. Journal of Biological Chemistry, 1979, 254, 2610–2618.PubMedGoogle Scholar
  31. Chang, K. J., and Cuatrecasas, P.: Heterogeneity and properties of opiate receptors. Federation Proceedings, 1981, 40, 2730–2734.Google Scholar
  32. Chavkin, C., and Goldstein, A.: Specific receptor for the opioid peptide dynorphin: Structure-activity relationships. Proceedings of the National Academy of Science USA, 1981, 78, 6543–6547.Google Scholar
  33. Chavkin, C., Bakhit, C., and Bloom F. E.: Evidence for dynorphin-A as a neurotransmitter in rat hippocampus. Life Sciences, 1983, 33, 13–16.PubMedGoogle Scholar
  34. Chesher, G. B. and Chan, B.: Footshock induced analgesia in mice: Its reversal by naloxone and cross tolerance with morphine. Life Sciences, 1977, 21, 1569–1574.PubMedGoogle Scholar
  35. Clark, W. G.: Influence of opiods on central thermoregulatory mechanisms. Pharmacology Biochemistry Behavior, 1979, 10, 609–613.Google Scholar
  36. Clendeninn, N. J., Petraitis, M., and Simon, E. J.: Ontological development of opiate receptors in rodent brain. Brain Research, 1976, 118, 157–160.PubMedGoogle Scholar
  37. Cohen, M. S., Rudolph, A. M., and Melmon, K. L.: Responses to morphine in the pregnant ewe. Pediatric Research, 1978, 12, 403.Google Scholar
  38. Cohen, M. S., Rudolph, A. M., and Melmon, K. L.: Antagonism of morphine by naloxone in pregnant ewes and fetal lambs. Developmental Pharmacological Theraphy, 1980, 1, 58–60.Google Scholar
  39. Cooper, S.: Naloxone: Effects on food and water consumption in the non-deprived and deprived rat. Psychopharmacology, 1980, 71, 1–6.PubMedGoogle Scholar
  40. Coyle, J. T., and Compochaiaro, P.: Ontogenesis of dopaminergic cholinergic interactions in the rat striatum: A neurochemical study. Journal of Neurochemistry, 1976, 27, 673–678.PubMedGoogle Scholar
  41. Coyle, J. T., and Pert, C. B.: Ontogenetic development of 3H-naloxone binding in rat brain. Neuropharmacology, 1976, 15, 555–560.PubMedGoogle Scholar
  42. D’Amour, F. E., and Smith, D. L.: A method for determining loss of pain sensation. Journal of Pharmacology and Experimental Therapeutics, 1941, 72, 74–79.Google Scholar
  43. Davis, W. M., and Lin, C. H.: Prenatal morphine effects on survival and behavior of rat offspring. Research Communications on Chemistry Pathology and Pharmacology, 1972, 3, 205–214.Google Scholar
  44. Dewey, W. L., and Harris, L. S.: The tail-flick test. In S. Ehrenpreis and A. Neidle (Eds.), Methods in narcotics research. New York: Marcel Dekker, 1975.Google Scholar
  45. Fanselow, M. S.: Shock-induced analgesia on the formalin test: Effects of shock severity, naloxone, hypophysectomy, and associative variables. Behavioral Neuroscience, 1984, 98, 79–95.PubMedGoogle Scholar
  46. Fanselow, M. S.: Odors released by stressed rats produce opioid analgesia in unstressed rats. Behavioral Neuroscience, 1985, 99, 589–592.PubMedGoogle Scholar
  47. Fanselow, M. S. and Baackes, M. P.: Conditioned fear-induced opiate analgesia on the formalin test: Evidence for two aversive motivational systems. Learning and Motivation, 1982, 13, 200–221.Google Scholar
  48. Fanselow, M. S., and Bolles, R. C.: Triggering of the endorphin analgesic reaction by a cue previously associated with shock: Reversal by naloxone. Bulletin of the Psychonomic Society, 1979, 14, 88–90.Google Scholar
  49. File, S. E.: Naloxone reduces social and exploratory activity in the rat. Psychopharmacology, 1980, 71, 41–44.PubMedGoogle Scholar
  50. Friedler, G., and Cochin, J.: Growth retardation in offspring of female rats treated with morphine prior to conception. Science, 1972, 175, 654–656.PubMedGoogle Scholar
  51. Goodman, R. R., Synder, S. H., Kuhar, M. J., and Young. W. S.: Differentiation of delta and mu receptors localizations by light microscopic autoradiography. Proceedings of the National Academy of Science USA, 1980, 77, 6239–6243.Google Scholar
  52. Grau, J. W., Hyson, R. L., Maier, S. F., Madden, J., IV, and Barchas, J. D.: Long-term stress induced analgesia and activation of the opiate system. Science, 1981, 213, 409–1410.Google Scholar
  53. Haber, S. N., and Watson, S. J.: The comparison between enkephalin-like and dynorphin-like immunoreactivity in both monkey and human globus pallidus and substantia nigra. Life Sciences, 1983, 33, 33–36.PubMedGoogle Scholar
  54. Handelman, G. E.: Neuropeptide administration to neonatal rats regulates sensitivity to peptides in adults. Neuroendocrinology Letters, 1983, 5, 186.Google Scholar
  55. Handelman, G. E., and Quirion, R.: Neonatal exposure to morphine increases u opiate binding in the adult forebrain. European Journal of Pharmacology, 1983, 94, 357–358.Google Scholar
  56. Hennessy, M. B., and Kaplan, J. N.: Influence of the maternal surrogate on pituitary-adrenal activity and behavior of infant squirrel monkeys. Developmental Psychobiology, 1982, 15, 423–431.PubMedGoogle Scholar
  57. Hennessy, M. B., Kaplan, J. N., Mendoza, S. P., Lowe, E. L., and Levine, S.: Separation distress and attachment in surrogate-reared squirrel monkeys. Physiology and Behavior, 1979, 23, 1017–1023.PubMedGoogle Scholar
  58. Herman, B. H., and Panksepp, J.: Effects of morphine and naloxone on separation distress and at attachment: Evidence for opiate mediation of social effect. Pharmacology Biochemistry Behavior, 1978, 9, 213–220.Google Scholar
  59. Herman, B. H., and Panksepp, J.: Ascending endorphine inhibition of distress vocalization. Science, 1981, 211, 1060–1062.PubMedGoogle Scholar
  60. Hoebel, B. G.: The psychopharmacology of feeding. In L. L. Iversen, S. D. Iversen, and S. H. Synder (Eds.), Handbook of psychopharmacology, Vol. 8. New York: Plenum Press, 1977.Google Scholar
  61. Holtzman, S. G.: Suppression of appetitive behavior in the rat by naloxone: Lack of effect of prior morphine dependence. Life Sciences, 1979, 24, 219–226.PubMedGoogle Scholar
  62. Hunter, G. A., Jr., and Reid, L. D.: Assaying addiction liability of opioids. Life Sciences, 1983, 33, 393–396.PubMedGoogle Scholar
  63. Hutchings, D. E.: Neurobehavioral effects of prenatal origin: Durgs of use and abuse. In R. H. Schwarz and S. J. Yaffe (Eds.), Drug and chemical risks to the fetus and newborn, progress in clinical and biological research, Vol. 36, New York: Alan R. Liss, 1980.Google Scholar
  64. Isom, G. E., and Elshowihy, R. M.: Interaction of acute and chronic stress with respiration: Modification by naloxone. Pharmacology Biochemistry and Behavior, 1982, 16, 599–603.Google Scholar
  65. Jacob, J. J., Tremblay, E. D., and Colombel, M. C.: Enhancement of nociceptive reactions by naloxone in mice and rats. Psychopharmacologia, 1974, 37, 217–223.PubMedGoogle Scholar
  66. Jaffe, J. H., and Martin, W. R.: Narcotic analgesics and antagonists. In L. S. Goodman and A. Gilman (Eds.), The pharmacological basis of therapeutics, 5th ed. New York: Macmillan, 1975.Google Scholar
  67. Johannesson, T., and Becker, B. A.: The effects of maternally-administered morphine on rat foetal development and resultant tolerance to the analgesic effect of morphine. Acta Pharmacologica Toxicology, 1972, 31, 305–313.Google Scholar
  68. Johannesson, T., and Becker, B. A.: Morphine analgesia in rats at various ages. Acta Pharmacologica Toxicology, 1973, 31, 305–313.Google Scholar
  69. Johanson, I. B., and Hall, W. G.: Appetitive learning in 1-day-old rat pups. Science, 1979, 205, 419–421.PubMedGoogle Scholar
  70. Katz, R. J. Naltrexone anatagonism of exploration in the rat. International journal of Neuroscience, 1979, 9, 49–52.PubMedGoogle Scholar
  71. Katz, R. J., and Gormezano, G.: A rapid and inexpensive technique for assessing the reinforcing effects of opiate drugs. Pharmacology Biochemistry Behavior, 1979, 11, 231–233.Google Scholar
  72. Katz, R. J., Carroll, B. J., and Baldrighi, G.: Behavioral activation by enkephalins in mice. Pharmacology Biochemistry and Behavior, 1978, 8, 493–496.Google Scholar
  73. Kehoe, P.: Behaviorally functional opioid systems in neonatal rats. Unpublished doctoral dissertation, Johns Hopkins University, Baltimore, 1985.Google Scholar
  74. Kehoe, P., and Blass, E. M.: Gustatory determinants of suckling in albino rats 5–20 days of age. Developmental Psychobiology, 1985, 18, 67–82.PubMedGoogle Scholar
  75. Kehoe, P., and Blass, E. M.: Behaviorally functional opioid systems in infant rats. I. Evidence for olfactory and gustatory classical conditioning. Behavioral Neuroscience, 1986a, 100. 359–367.PubMedGoogle Scholar
  76. Kehoe, P., and Blass, E. M.: Behaviorally functional opioid system in infant rats. H. Evidence for pharmacological, physiological and psychological mediation of pain and stress. Behavioral Neuroscience, 1986b, 5, 624–630.Google Scholar
  77. Kehoe, P., and Blass, E. M.: Central nervous system mediation of positive and negative reinforcement in neonatal albino rats. Developmental Brain Research, 1986c, 27, 69–75.Google Scholar
  78. Kehoe, P., and Blass, E. M.: Conditioned aversions and their memories in 5-day-old rats during suckling. journal of Experimental Psychology: Animal Behavior Processes, 1986d 12, 40–47.PubMedGoogle Scholar
  79. Kehoe, P., and Blass, E. M.: Opioid-mediation of separation distress in 10-day-old rats: Reversal of stress with maternal stimuli. Developmental Psychobiology, 1986e, 19, 385–398.PubMedGoogle Scholar
  80. Khachaturian, H., Alessi, N. E., Munfakh, N., and Watson, S.J.: Ontogeny of opioid and related peptides in the rat CNS and pituitary: An immunocytochemical study. Life Sciences, 1983, 33, 61–64.PubMedGoogle Scholar
  81. Khachaturian, H., Lewis, M. E., Schafer, M. K., and Watson, S. J.: Anatomy of the CNS opioid systems. Trends in Neuroscience, 1985, 8, 111–119.Google Scholar
  82. Kirby, M. L.: Effects of morphine on spontaneous activity of 18-day rat fetus. Developmental Neuroscience, 1979, 2, 238–244.PubMedGoogle Scholar
  83. Kirby, M. L.: Reduction of fetal rat spinal cord volume following maternal morphine injection. Brain Research, 1980, 202, 143–150.PubMedGoogle Scholar
  84. Kirby, M. L.: Development of opiate receptor binding in rat spinal cord. Brain Research, 1981a, 205, 400–404.PubMedGoogle Scholar
  85. Kirby, M. L.: Effects of morphine and naloxone on spontaneous activity of fetal rats. Experimental Neurology, 1981b, 73. 430–439.PubMedGoogle Scholar
  86. Kirby, M. L.: An ultrastructural morphometric study of developing rat substantia gelatinosa. The Anatomical Record, 1981e, 200, 231–237.PubMedGoogle Scholar
  87. Kupferberg, H. J., and Way, E. L.: Pharmacologic basis for the increased sensitivity of the newborn rat to morphine. Journal of Pharmacology adn Experimental Therapy, 1963, 141, 105–112.Google Scholar
  88. Lal, H. Miksic, S., adn Smith, N.: Naloxone antagonism of conditioned hyperthermia: An evidence for release of endogenous opioid. Life Science, 1976, 18, 971–976.Google Scholar
  89. Lewis, J. W. Cannon, J. T., and Liebeskind, J. C.: Opioid nonopioid mechanisms of stress analgesia. Science, 1980, 208, 623–625.PubMedGoogle Scholar
  90. Lewis, J. W., Shavit, Y., Terman, G. W., Nelson, L. R., Gale, R. P., and Liebeskind, J. C.: Apparent involvement of opioid peptides in stress-induced enhancement of tumor growth. Peptides, 1983, 4, 635–638.PubMedGoogle Scholar
  91. Lieblich, I., Cohen, E., Ganchrow, J. R., Blass, E. M., and Rergmann, F.: Morphine tolerance in genet-ically selected rats induced by chronically elevated saccharine intake. Science, 1983, 221, 871–873.PubMedGoogle Scholar
  92. Loughlin, S. E., Massamiri, T. R., Kornblum, H. I., and Leslie, F. M.: Postnatal development of opioid systems in rat brain. Neuropeptides, 1985, 5, 469–472.PubMedGoogle Scholar
  93. Lubek, M. J., and Wilber, J. F.: Regional distribution of leucine enkephalin in hypothalamic and extra- hypothalamic loci of the human nervous system. Neuroscience Letters, 1980, 18, 155–161.Google Scholar
  94. Mayer, D. J.: Neural mechanisms of multiple endogenous analgesia systems. Presentation at the New York Academy of Sciences Conference on Stress-Induced Analagesia, New York, 1985.Google Scholar
  95. McGinty, J. F., and Ford, D. H.: The effects of maternal morphine or methadone intake on the growth, reflex development and maze behavior of rat offspring. In D. H. Ford and D. H. Clouet (Eds.), Tissue responses to addictive drugs. New York: Spectrum Publications, 1976.Google Scholar
  96. Miller, R. J.: The enkephalins. In L. I. Iversen, S. D. Iversen, and S. H. Snyder (Eds.), Handbook of psychopharmacology, Vol. 16. New York: Plenum Press, 1983.Google Scholar
  97. Morley, J. E.: The endocrinology of the opiates and the opioid peptides. Metabolism, 1981, 30, 195209.Google Scholar
  98. Morley, J. E., Levine, A. S., Murray, S. S., and Kneip, J.: Peptidergic regulation of norepinephrineinduced feeding. Pharmacology Biochemistry Behavior, 1982, 16, 225–228.Google Scholar
  99. Morley, J. E., Levine, A. S., Yim, G. K., and Lowy, M. T.: Opioid modulation of appetite. Neuroscience and Behavioral Reviews, 1983, 7, 281–305.Google Scholar
  100. Mucha, R. F., and Iversen, S. D.: Reinforcing properties of morphine and naloxone revealed by condi-tioned place preferences: A procedural examination. Psychopharmacology, 1984, 82, 241–247.PubMedGoogle Scholar
  101. Mucha, R. F., and van der Kooy, D.: Reinforcing effects of intravenous and intracranial opiates revealed by a place preference paradigm. Neuroscience Abstracts, 1979, 5, 657.Google Scholar
  102. Mucha, R. F., van der Kooy, D., O’Shaughnessy, M., and Buceniecks, P.: Drug reinforcement studied by the use of place conditioning in rat. Brain Research, 1982, 243, 91–105.PubMedGoogle Scholar
  103. Narayanan, C. H., Fox, M. W., and Hamburger, V.: Prenatal development of spontaneous and evoked activity in the rat (Rattus norwegicus albinos). Behavior, 1971, 40, 100–134.Google Scholar
  104. Newby-Schmidt, M. B., and Norton, S.: Alterations of chick locomotion produced by morphine treatment in ovo. Neurotoxicology, 1981, 2, 743–748.PubMedGoogle Scholar
  105. Ngai, S. H., Berkowitz, B. A., Yang, J. C., Hempstead, J., and Spector, S.: Pharmacokinetics of naloxone in rats and in man. Anestheiology, 1976, 44, 398–401.Google Scholar
  106. Noirot, E.: Ultrasounds and maternal behavior in small rodents. Developmental Psychobiology, 1972, 5, 371–387.PubMedGoogle Scholar
  107. O’Callaghan, J. P., and Holtzman, S. G.: Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure. Journal of Pharmacology and Experimental Therapeutics, 1975, 192, 497–505.PubMedGoogle Scholar
  108. O’Callaghan, J. P., and Holtzman, S. G.: Prenatal administration of morphine to the rat: Tolerance to the analgesic effect of morphine in the offspring. Journal of Pharmacology experimental Toxicology, 1976, 197, 533–544.Google Scholar
  109. Panksepp, J.: Brain opioids-A neurochemical substrate for narcotic and social dependence. In S. J. Cooper (Ed.), Theory in psychopharmacology, London: Academic Press, 1981.Google Scholar
  110. Panksepp, J. and DeEskinazi, F. G.: Opiates and homing. Journal of Comparative and Physiological Psychology, 1980, 94, 650–663.PubMedGoogle Scholar
  111. Panksepp, J., Herman, B., Conner, R., Bishop, P., and Scott, J. P.: The biology of social attachments: Opiates alleviate separation distress. Biological Psychiatry, 1978a, 13, 607–618.PubMedGoogle Scholar
  112. Panksepp, J., Vilberg, T., Bean, N. J., Coy, D. H., and Kastin, A. J.: Reduction of distress vocalization in chicks in opiate-like peptides. Brain Research Bulletin, 1978b, 3, 663–667.PubMedGoogle Scholar
  113. Panksepp, J., Meeker R., and Bean, D. H.: The neurochemical control of crying. Pharmacology Biology and Behavior, 1980, 12, 437–443.Google Scholar
  114. Panksepp, J., Siviy, S. M., and Normansell, L. A.: Brain opioids and social emotions. In M. Reite and T. Fields (Eds.), Biology of social attachments. New York: Academic Press, 1985b.Google Scholar
  115. Panksepp, J., Conner, R., Forster, P., Bishop, P., and Scott, J. P.: Opioid effects on social behavior of kennel dogs. Applied Animal Ethology, 1983, 10, 63–74.Google Scholar
  116. Panksepp, J., Jalowiec, J., DeEskinazi, F. G., and Bishop, P.: Opiates and play dominance in juvenile rats. Behavioral Neuroscience, 1985a, 99, 441–453.PubMedGoogle Scholar
  117. Panksepp, J., Siviy, S. M., and Normansell, L. A.: Brain opioids and social emotions. In M. Reite and T. Fields (Eds.), Biology of social attachments. New York: Academic Press, 1985b.Google Scholar
  118. Pasternak, G. W., and Snyder, S. H.: Identification of novel high affinity opiate receptor binding in rat brain. Nature, 1975, 253, 563–564.PubMedGoogle Scholar
  119. Pasternak, G. W., Zhang, A., and Tecott, L.: Developmental differences between high and low affinity opiate binding sites: Their relationship to analgesia and respiratory depression. Life Sciences, 1980, 27, 1185–1190.PubMedGoogle Scholar
  120. Patey, G., de la Baume, S., Gros, C., and Schwartz, J. C.: Ontogenesis of enkephalinergic systems in rat brain: post-natal changes in enkephalin levels, receptors and degrading enzyme activities. Life Sciences, 1980, 27, 245–252.PubMedGoogle Scholar
  121. Pedersen, P. E., Williams, C. L., and Blass, E. M.: Activation and odor conditioning of suckling behavior in 3-day-old albino rats. Journal of Experimental Psychology Animal Behavior Processes, 1982, 8, 329–342.PubMedGoogle Scholar
  122. Pert, A., and Yaksh, T. L.: Sites of morphine-induced analgesia in the primate brain: Relation to pain pathways. Brain Research, 1974, 80, 135–150.PubMedGoogle Scholar
  123. Quirion, R., Weiss, A. S., and Pert, C. B.: Comparative pharmacological properties and autoradiographic distribution of (3H) ethylketocyclazocine binding sites in rat and guinea pig brain. Life Sciences, 1983, 33, 183–186.PubMedGoogle Scholar
  124. Rossi, N. A., and Reid, L. D.: Affective states associated with morphine injections. Physiological Psychology, 1976, 4, 269–274.Google Scholar
  125. Roth, K. A., and Katz, R. J.: Stress, behavioral arousal and activity-A reexamination of emotionality in the rat. Neuroscience and Biobehavioral Reviews, 1979, 3, 247–263.PubMedGoogle Scholar
  126. Rudy, J. W., and Cheatle, M. D.: Ontogeny of association learning: Acquisition of odor aversions by neonatal rats. In N. E. Spear and B. A. Campbell (Eds.), Ontogeny of learning and memory, Hillsdale, NJ: Erlbaum, 1979.Google Scholar
  127. Sadee, W., Richards, M. L., Grevel, J., and Rosenbaum, J. S.: “In vivo” characterization of four types of opioid binding sites in rat brain. Life Sciences, 1983, 33, 187–189.PubMedGoogle Scholar
  128. Satoh, M., Kawajiri, S., Yamamoto, M., Makino, H., and Tagaki, H.: Reversal by naloxone of adaptation of rats to noxious stimuli, Life Sciences, 1979, 25, 685–690.Google Scholar
  129. Selye, H.: Stress in health and disease. Woburn, MA: Butterworths, 1976.Google Scholar
  130. Sherman, J. E., and Liebeskind, J. C.: An endorphinergic, centrifugal, substrate of pain modulation: Recent findings, current concepts, and complexities. In J. J. Bonica (Ed.), Pain. New York: Raven Press, 1980.Google Scholar
  131. Sherman, J. E., Proctor, C., and Strub, H.: Prior hot plate exposure enhances morphine analgesia in tolerant and drug-naive rats. Pharmacology Biochemistry Behavior, 1982, 17, 229–232.Google Scholar
  132. Sherman, E. J., Strub, H., and Lewis, J. W.: Morphine-Analgesia: Enhancement by shock-associated cues. Behavioral Neuroscience, 1984, 98. 293–309.PubMedGoogle Scholar
  133. Simon, E. J., and Hiller, J. M.: Multiple opioid receptors. In J. Hughes, H. O. J. Collier, M. J. Rance, and M. B. Tyers (Eds.), Opioids past present and future. Philadelphia, PA: Taylor & Francis, 1984.Google Scholar
  134. Sircar, R., and Zukin, S. R.: Ontogeny of sigma opiate/phencyclidine binding sites in the brain. Life Sciences, 1983, 33, 255–258.PubMedGoogle Scholar
  135. Slotkin, T. A., Seidler, F. J., and Whitmore, W. L.: Precocious development of sympatho-adrenal func- tion in rats whose mothers received methadone. Life Sciences, 1980, 26, 1657–1663.PubMedGoogle Scholar
  136. Smith, G. J., and Spear, N. E.: Effects of the home environment on withholding behaviors and condi-tioning in infant and neonatal rats. Science, 1978, 202, 327–329.PubMedGoogle Scholar
  137. Smotherman, W. P., and Robinson, S. R.: The uterus as environment: The ecology of fetal experiences. In E. M. Blass (Eds.), Developmental psychobiology and behavioral ecology. New York: Plenum Press, 1987.Google Scholar
  138. Smotherman. W. P., Hunt, L. E., McGinnis, L. M., and Levine, S.: Mother-infant separation in group- living rhesus macaques: A hormonal analysis. Developmental Psychobiology, 1979, 12, 211–217.PubMedGoogle Scholar
  139. Snyder, S. H.: Drug and neurotransmitter receptors in the brain. Science, 1984, 224, 22–31.PubMedGoogle Scholar
  140. Sobrian, S. K.: Prenatal morphine administration alters behavioral development in the rat. Pharmacology Biochemistry Behavior, 1977, 7, 285–288.Google Scholar
  141. Spain, J. W., Bennett, D. B., Roth, B. L., and Coscia, C. J.: Ontogeny of benzomorphan-selective (K) sites: A computerized analysis. Life Sciences, 1983, 33, 235–238.PubMedGoogle Scholar
  142. Spain, J. W., Roth, B. L., and Coscia, C. J.: Differential ontogeny of multiple opioid receptors (mu, delta, and kappa), Journal of Neuroscience, 1985; 5, 584–588.PubMedGoogle Scholar
  143. Spear, L. P., Enters, E. K., Aswad, M. A., and Louzan, M.: Drug and environmentally-induced manipulations of the opiate and serotonergic systems alter nociception in neonatal rat pups. Behavioral and Neural Biology, 1985, 44, 1–20.PubMedGoogle Scholar
  144. Steele, W. J., and Johannesson, T.: Effects of morphine infusion in maternal rats at near-term on ribosome size distribution in foetal and maternal rat brain. Acta Pharmacologica Toxicologica, 1975, 36, 236–242.Google Scholar
  145. Stickrod, G., Kimbel, D. P., and Smotherman, W. P.: Methionine-enkephalin effects on associations formed in utero. Peptides, 1982, 3, 881–884.PubMedGoogle Scholar
  146. Stoloff, M. L., Kenny, J. T., Blass, E. M., and Hall, W. G.: The role of experience in suckling maintenance in albino rats. Journal of Comparative and Physiological Psychology, 1980, 94, 847–856.Google Scholar
  147. Ternes, J. W., Ehrman, R. N., and O’Brien, C. P.: Nondependent monkeys self-administer hydromorphone. Behavioral Neuroscience, 1985, 99, 583–588.PubMedGoogle Scholar
  148. Tsang, D., and Ng, S. C.: Effect of antenatal exposure to opiates on the development of opiate receptors in rat brain. Brain Research, 1980, 188, 199–206.PubMedGoogle Scholar
  149. Tsang, D., Ng, S. C., Ho, K. P., and Ho, W. K. K.: Ontogenesis of opiate binding sites and radioimmunoassayable b-endorphin and enkephalin in regions of rat brain. Developmental Brain Research, 1982, 5, 257–261.Google Scholar
  150. VanRee, J. M., and Niesink, R. S. M.: Low doses of beta-endorphin increase social contacts of rats tested in dyadic encounters. Life Sciences, 1983, 33, 611–614.Google Scholar
  151. Vertes, Z., Melegh, G., Vertes, M., and Kovacs, S.: Effect of naloxone and D-met2- pro5-enkephalinam-ide treatment on the DNA synthesis in the developing rat brain. Life Sciences, 1982, 31, 119–126.PubMedGoogle Scholar
  152. Watson, S. J., and Barchas, J. D.: Anatomy of the endogenous opioid peptides and related substance: The enkephalins, beta-endorphin, beta-lipotropin and ACTH. In R. F. Beers and E. G. Bassett (Eds.), Mechanism of pain and analgesic compounds, New York: Raven Press, 1979.Google Scholar
  153. Watson, S. J., Akil, H., Khachaturian, H., Young, E., and Lewis, M. E.: Opioid systems: Anatomical, physiological and clinical perspectives. In J. Hughes, H. O. J. Collier, M. J. Rance, and M. B. Tyers (Eds.), Opioids past, present and future. Philadelphia, PA: Taylor and Francis, 1984.Google Scholar
  154. Whiteside, D. A., and Devenport, L. D.: Naloxone, preshock, and defensive burying. Behavioral Neuroscience, 1985, 99, 436–440.PubMedGoogle Scholar
  155. Yaksh, T. L., and Rudy, T. A.: Analgesia mediated by direct spinal action of narcotics. Science, 1978, 192, 1357–1358.Google Scholar
  156. Zagon, I., and McLaughlin, P.: Morphine and brain growth retardation in the rat. Pharmacology, 1977, 15, 276–282.PubMedGoogle Scholar
  157. Zagon, I., and McLaughlin, P.: Increased brain size and cellular content in infant rats treated with an opiate antagonist. Science, 1983, 221, 1179–1180.PubMedGoogle Scholar
  158. Zamir, N., Simantov, R., and Segal, M.: Pain sensitivity and opioid activity in genetically and experimentally hypertensive rats. Brain Research, 1980, 184, 229–310.Google Scholar
  159. Zhang, A. Z., and Pasternak, G. W.: Opiates and enkephalins: A common binding site mediates their analgesic actions in rats. Life Sciences, 1981, 29, 843–851.PubMedGoogle Scholar
  160. Zimmerberg, B., Charap, A. D., and Glick, S. D.: Behavioral effects of in utero administration of morphine. Nature, 1974, 247, 376–377.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Priscilla Kehoe
    • 1
  1. 1.Department of PsychologyTrinity CollegeHartfordUSA

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