Anergy in Experimental Mouse Models of Mycobacterial Infection
Unresponsiveness, or anergy, is often observed in association with active tuberculosis and other mycobacterial diseases, both in the clinical setting and in experimental animal models of these infections. In both clinical and experimental laboratory settings, various manifestations of anergy can be observed using both in vitro and in vivo approaches. In the case of the former, most in vitro observations of anergy following mycobacterial infection consist of the measurement of a reduced capacity of lymphocytes to undergo blastogenic transformation in response to stimulation by mitogens, by specific antigens associated with the infecting organism, or by alloantigens in a mixed lymphocyte culture. As for in vivo expressions of anergy, these are most usually measured as a reduction or loss of the capacity of the infected host to mount a delayed-type hypersensitivity (DTH) response to a cutaneous injection of specific antigen.
KeywordsSpleen Cell Infected Mouse Mycobacterial Infection Mycobacterium Bovis Mixed Lymphocyte Culture
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