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Mycobacterium avium-Complex Infections and Immunodeficiency

  • Frank M. Collins
Part of the Infectious Agents and Pathogenesis book series (IAPA)

Abstract

The atypical mycobacteria constitute a diverse and heterogeneous group of acid-fast bacilli that are widespread in distribution throughout the natural environment.1 They also include a number of important opportunistic human and animal pathogens.2 Most organisms in this group are not considered pathogenic for immunocompetent adults, although they do occasionally establish residence within normal tissues, where they give rise to persistent infections that can be difficult to eliminate, due to their high resistance to most antituberculosis drugs.3 Such systemic infections are usually associated with some other underlying disease, such as silicosis, emphysema, or Hodgkin disease. A few species (e.g., M. kansasii, M. avium, and M. ulcerans) are considered overt human pathogens, causing progressive pathologic changes within the infected tissues.4 Although most cases of pulmonary tuberculosis are caused by M. tuberculosis, small numbers of M. kansasii and M. avium infections are reported each year. When combined, these pathogens are responsible for at least 2 million deaths worldwide each year,5 with the atypical mycobacterial infections constituting perhaps 5% of the total patient population.6 These organisms are generally considered much less virulent for humans than M. tuberculosis,7 although recently they have become a matter for concern due to the increasing acquired immunodeficiency syndrome (AIDS) epidemic.8

Keywords

Acquire Immune Deficiency Syndrome Acquire Immunodeficiency Syndrome Mycobacterial Infection Nontuberculous Mycobacterium Acquire Immune Deficiency Syndrome Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Frank M. Collins
    • 1
  1. 1.Trudeau Institute, Inc.Saranac LakeUSA

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