Immunoregulatory Function of Mononuclear Phagocytes in Tuberculosis

  • Jerrold J. Ellner
Part of the Infectious Agents and Pathogenesis book series (IAPA)


A complete understanding of the interaction of Mycobacterium tuberculosis with the host would explain several distinctive epidemiologic and clinical features of human tuberculosis. Following primary infection with M. tuberculosis, the usual course is resolution, without specific drug treatment; only 5–15% of infected individuals develop overt tuberculosis. Factors predisposing to progression of the primary infection or delayed reactivation of a latent focus are not well understood. It is clear, however, that major deficits in cell-mediated immunity are associated with increased risk of progressive tuberculosis.


Major Histocompatibility Complex Adherent Cell Tuberculosis Patient Pulmonary Tuberculosis Mononuclear Phagocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Pollack, M. S., and Rich, R. R., 1985, The HLA complex and the pathogenesis of infectious diseases, J. Infect. Dis. 151: 1–8.PubMedCrossRefGoogle Scholar
  2. 2.
    Nash, D. R., and Douglas, J. E., 1980, Anergy in active pulmonary tuberculosis, Chest 77:32–37.PubMedCrossRefGoogle Scholar
  3. 3.
    Rooney, J. J. ,Jr., Crocco, J. A., Kramer, S., and Lyons, H. A. ,1976, Further observations on Tuberculin Reactions in Active Tuberculosis. Am. J. Med. 60:517–522.PubMedCrossRefGoogle Scholar
  4. 4.
    Douvas, G. S., Looker, D. L., Vatter, A. E., and Crowle, A. J., 1985, Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria, Infect. Immun. 50: 1–8.PubMedGoogle Scholar
  5. 5.
    Ellner, J. J., 1981, Suppressor cells of man, Clin. Immunol. Rev. 1: 119–214.PubMedCrossRefGoogle Scholar
  6. 6.
    Ellner, J. J., and Spagnuolo, P. J., 1979, Suppression of antigen and mitogen-induced T-lymphocyte DNA synthesis by bacterial lipopolysaccharide. Mediation by macrophage activation and production of prostaglandins, J. Immunol. 123:2689–2695.PubMedGoogle Scholar
  7. 7.
    Kleinhenz, M. E., and Ellner, J. J., 1983, Divergent T-gamma cell functions in antigen-induced blastogenesis: facilitatory interaction with T non-gamma cells and participation in monocyte and prostaglandin-mediated suppression, J. Lab. Clin. Med. 102:751– 761.PubMedGoogle Scholar
  8. 8.
    Ellner, J. J., and Daniel, T. M. ,1979, Immunosuppression by mycobacterial ara-binomannan, Clin. Exp. Immunol. 35:250–257.PubMedGoogle Scholar
  9. 9.
    Kleinhenz, M. E., Ellner, J. J., Spagnuolo, P. J., and Daniel, T. M., 1981, Suppression of lymphocyte responses by tuberculous plasma and mycobacterial arabinogalactan: Monocyte dependence and indomethacin reversibility, J. Clin. Invest. 68: 153–162.PubMedCrossRefGoogle Scholar
  10. 10.
    Ellner, J. J., 1978, Suppressor adherent cells in human tuberculosis, J. Immunol. 121:2573–2578.PubMedGoogle Scholar
  11. 11.
    Toossi, Z. ,Kleinhenz, M. E., and Ellner, J. J., 1986, Defective interleukin-2 production and responsiveness in human pulmonary tuberculosis, J. Exp. Med. 163: 1162–1172.PubMedCrossRefGoogle Scholar
  12. 12.
    Kleinhenz, M. E., and Ellner, J. J., 1985, Immunoregulatory adherent cells in human tuberculosis: Radiation-sensitive antigen-specific suppression by monocytes, J. Infect. Dis. 152:171–176.PubMedCrossRefGoogle Scholar
  13. 13.
    Kleinhenz, M. E., and Ellner, J. J., 1987, Antigen responsiveness during tuberculosis: Regulatory interactions of T-cell subpopulations and adherent cells, J. Lab. Clin. Med. 110:31–40.PubMedGoogle Scholar
  14. 14.
    Ellner, J. J., Spagnuolo, P. J., and Schacter, B. Z. ,1981, Augmentation of selective monocyte functions in tuberculosis, J. Infect. Dis. 144:391–398.PubMedCrossRefGoogle Scholar
  15. 15.
    Tweardy, D. J., Schacter, B. Z., and Ellner, J. J., 1984, Association of altered dynamics of monocyte surface expression of human leukocyte antigen-DR with immunosuppression in tuberculosis, J. Infect. Dis. 149:31–37.PubMedCrossRefGoogle Scholar
  16. 16.
    Stallcup, K. C., Liu, Y.-N., Dorf, M. E., and Mescher, M. F., 1986, Inhibition of lymphoid cell growth by a lipid-like component of macrophage hybridoma cells, J. Immunol. 136:2723–2728.PubMedGoogle Scholar
  17. 17.
    Fujiwara, H., Kleinhenz, M. E., Wallis, R. S., and Ellner, J. J., 1986, Increased in-terleukin-1 production and monocyte suppressor cell activity associated with human tuberculosis, Am. Rev. Respir. Dis. 133:73–77.PubMedGoogle Scholar
  18. 18.
    Wallis, R. S., Fujiwara, H., and Ellner, J. J. ,1986, Direct stimulation of monocyte release of interleukin-1 by mycobacterial protein antigens, J. Immunol. 136:193–196.PubMedGoogle Scholar
  19. 19.
    Fujiwara, H., and Ellner, J. J., 1986, Spontaneous production of a suppressor factor by the human macrophage-like cell line U937. I. Suppression of interleukin-1, in-terleukin-2 and mitogen-induced blastogenesis in mouse thymocytes, J. Immunol. 136:181–185.PubMedGoogle Scholar
  20. 20.
    Liao, Z. ,Grimshaw, R. S., and Rosenstreich, D. L., 1984, Identification of a specific interleukin-1 inhibitor in the urine of febrile patients, J. Exp. Med. 159:126–136.PubMedCrossRefGoogle Scholar
  21. 21.
    Mason, U. G. III, Greenberg, L. E., Yen, S. S., and Kirkpatrick, C. H., 1982, Indo-methacin-responsive mononuclear cell dysfunction in “atypical” mycobacteriosis, Cell. Immunol. 71:54–65.PubMedCrossRefGoogle Scholar
  22. 22.
    Mason, U. G. III, and Kirkpatrick, C. H., 1984, Modulation of immunologic responsiveness in nontuberculous mycobacterial infections with indomethacin, J. Clin. Immunol. 4:112–117.PubMedCrossRefGoogle Scholar
  23. 23.
    Wadee, A. A., Mendelsohn, D., Rabson, A. R., 1983, Characterization of a suppressor-cell activating factor (SCAF) released by adherent cells treated with M. tuberculosis, J. Immunol. 130:2266–2270.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jerrold J. Ellner
    • 1
  1. 1.Case Western Reserve University and University Hospitals of ClevelandClevelandUSA

Personalised recommendations