Potentiation of NGF-mediated Effects of Laminin

  • Ann Acheson
  • Hans Thoenen
Part of the Wenner-Gren Center International Symposium Series book series (WGCISS)


Nerve growth factor (NGF) is a well-defined protein which is necessary for the development and maintainance of differentiated properties of peripheral sympathetic and neural crest-derived sensory neurons (for review see Thoenen et al., 1985 and refs therein). Many morphological and biochemical effects of NGF have been described in both the physiological target cells of NGF and a clonal cell line (PC12) derived from a rat pheochromocytoma. NGF is known to bind to specific cell-surface receptors, an event which is followed by internalization of the ligand-receptor complex; however, the mechanism of signal transduction after NGF’s interaction with its receptor is unknown.


PC12 Cell Nerve Growth Factor Tyrosine Hydroxylase Neurite Outgrowth Chromaffin Cell 
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© The Wenner-Gren Center 1987

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  • Ann Acheson
  • Hans Thoenen

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