Receptor Regulation and Receptor-Receptor Communication

  • M. D. Hollenberg
Part of the Wenner-Gren Center International Symposium Series book series (WGCISS)


As recently as five years ago, what one might term the “grind and bind era” of receptor studies was still in full bloom; and a large number of studies were focussed on determining receptor affinities and numbers under a variety of physiologic situations. It became clear from such studies that receptors are not static elements, fixed in the cell membrane at a single site. Rather, it is now fully appreciated that receptors for neurotransmitters, hormones and other messenger molecules are dynamic elements both in the plasma membrane and in the cytoplasmic compartment, as outlined in Fig. 1.


Receptor Function Receptor Domain Receptor Regulation Transmembrane Signalling Covalent Reaction 
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© The Wenner-Gren Center 1987

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  • M. D. Hollenberg

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