Control of Plasma Membrane Transducing Systems by Second Messengers and by Cellular Metabolism

  • Howard Rasmussen
  • Paula Barrett
Part of the Wenner-Gren Center International Symposium Series book series (WGCISS)


The focus of this meeting on receptor-receptor interactions is not so much on the direct interaction of one receptor protein molecule with another different protein receptor molecule, but rather on the immediate products of the transducing events mediated by one class of receptors acting as modulators of the functions of a second class of receptors. This is a special case of a much larger phenomenon, that of the interactions between components of one messenger system, e.g., the Ca2+ messenger system, with those in another, e.g., the cAMP messenger system (Rasmussen, 1981). It is an intramembrane integrative mechanism. The special feature of the receptor-receptor theme is that the interactions are those which specifically influence other transducing events at the level of the plasma membrane. Even within this category of interactions, receptor-receptor interactions are only one example of this class of phenomena. We will first discuss examples of receptor-receptor interaction in endocrine systems, and then focus attention on two other types of control processes in which a coupling occurs between a transducing event and either a change in ion transport or a change in cellular metabolism. We do so for two reasons: first, to emphasize the fact that signal transducing events other than those directly linked to receptor-transducer interactions are an important feature of plasma membrane function; and second, to emphasize the importance of these membrane-linked events in the regulation of sustained cellular responses.


Insulin Secretion Adenylate Cyclase Phosphatidic Acid Influx Rate Messenger System 
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© The Wenner-Gren Center 1987

Authors and Affiliations

  • Howard Rasmussen
  • Paula Barrett

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