Receptor-Receptor Interactions Mediated by Protein Phosphorylation
There is now convincing evidence that protein phosphorylation mediates the physiological effects of a variety of extracellular signals on their target cells, both neuronal and non-neuronal. For many years, the hypothesis (Kuo and Greengard, 1969; Greengard, 1976) that protein phosphorylation mediates certain of the actions of neurotransmitters on target neurons was based largely on correlations between the state of phosphorylation of one or another substrate protein and the state of some physiological response in target neurons. However, during the past five or six years direct evidence has been obtained for a role of protein phosphorylation in the regulation of physiological processes in nerve cells. Thus, there is now evidence, based on intracellular injection experiments, that each of the four major classes of protein:kinases listed in Table I mediates the actions of certain neurotransmitters acting on their target nerve cells.
KeywordsAcetylcholine Receptor Protein Phosphorylation Nicotinic Acetylcholine Receptor Calcium Current Dependent Protein Kinase
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