Are Opiates Involved in the Adaptation Processes of Dopamine Receptors that Follow Chronic Drug Exposure?

  • Antonio Groppetti
  • Luigina Rusconi
  • Eugenio Parati
  • Marco Parenti
Part of the Wenner-Gren Center International Symposium Series book series (WGCISS)


A number of evidences have appeared over the years in the literature which indicate that opiates alter the activity of dopaminergic neurons and affect the responsiveness to dopamino-mimetic or dopamino-lithic drugs. In several animal species opiates, similarly to neuroleptics, increase the rate of dopamine (DA) turnover and the concentrations of homovanillic and dihydroxyphenylacetic acids in the striatum, enhance the firing rate of DA cells in the zona compacta of the substantia nigra and induce a catatonic-like state (Lal, 1975). Cross tolerance with haloperidol has been reported in animals made dependent upon morphine (Puri and Lal, 1974). Laboratory tests have also shown that naloxone potentiated the effects of apomorphine and antagonized the behavioural responses induced by amphetamine (Holtzman, 1974; Dettmar et al., 1978; Agnati et al., 1979; Quock, 1981; Ferrari and Baggio, 1982; Quock et al., 1983).


Dopamine Receptor Adenylate Cyclase Opiate Receptor Chronic Morphine Chronic Morphine Treatment 
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© The Wenner-Gren Center 1987

Authors and Affiliations

  • Antonio Groppetti
  • Luigina Rusconi
  • Eugenio Parati
  • Marco Parenti

There are no affiliations available

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