Receptor Interactions in Antidepressant Neurochemical Mechanisms: Modulation by Membrane Components
Recent studies on the mechanism of action of antidepressant drugs have focussed on alterations in monoaminergic neurons following prolonged drug administration, since only those effects elicited after long term antidepressant treatment might be the biochemical substrate accounting for the delayed onset of therapeutic activity (Racagni and Brunello, 1984). Chronic antidepressant administration is associated with several adaptive changes in central monoaminergic systems, which can occur both pre- and postsynaptically (Sugrue, 1983). One of the most significant and constant effect shared by all the treatments that are known to relieve depression, including electroconvulsive therapy, is the down-regulation of beta adrenergic receptors (Banerjee et al., 1977) coupled to the desensitization of noradrenaline (NE) dependent adenylate cyclase (Vetulani and Sulser, 1975). Moreover among the possible mechanisms responsible for the adaptation of central aminergic neurons following antidepressant administration, the interaction between serotonergic and noradrenergic system and changes in the chemico-physical properties of the membranes should be considered.
KeywordsAntidepressant Drug Noradrenergic System Cortical Slice Cortical Membrane Monoaminergic Neuron
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