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Receptor Interactions in Antidepressant Neurochemical Mechanisms: Modulation by Membrane Components

  • N. Brunello
  • U. Cicerano
  • A. C. Rovescalli
  • M. Riva
  • R. Galimberti
  • C. Franzetti
  • G. Racagni
Part of the Wenner-Gren Center International Symposium Series book series (WGCISS)

Abstract

Recent studies on the mechanism of action of antidepressant drugs have focussed on alterations in monoaminergic neurons following prolonged drug administration, since only those effects elicited after long term antidepressant treatment might be the biochemical substrate accounting for the delayed onset of therapeutic activity (Racagni and Brunello, 1984). Chronic antidepressant administration is associated with several adaptive changes in central monoaminergic systems, which can occur both pre- and postsynaptically (Sugrue, 1983). One of the most significant and constant effect shared by all the treatments that are known to relieve depression, including electroconvulsive therapy, is the down-regulation of beta adrenergic receptors (Banerjee et al., 1977) coupled to the desensitization of noradrenaline (NE) dependent adenylate cyclase (Vetulani and Sulser, 1975). Moreover among the possible mechanisms responsible for the adaptation of central aminergic neurons following antidepressant administration, the interaction between serotonergic and noradrenergic system and changes in the chemico-physical properties of the membranes should be considered.

Keywords

Antidepressant Drug Noradrenergic System Cortical Slice Cortical Membrane Monoaminergic Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Banerjee, S.P., Kung, L.S., Riggi, S.J., and Chande, S.K. (1977). Development of beta-adrenergic receptor subsensitivity by antidepressants. Nature (Lond.), 268, 455–456.CrossRefGoogle Scholar
  2. Berridge, M.J., Downes, C.P., and Hanley, M.R. (1982). Lithium amplifies agonist dependent phosphatidylinositol responses in brain and salivary glands. Biochem. J., 206, 587–595.Google Scholar
  3. Brunello, N., Barbaccia, M.L., Chuang, D.M., and Costa, E. (1982). Down regulation of beta-adrenergic receptors following repeated desimipramine injections; permissive role of serotonergic axons. Neuropharmacology, 21, 1145–1149.CrossRefGoogle Scholar
  4. Brunello, N., Mocchetti, I., Volterra, A., Cuomo, V., and Racagni, G. (1985a). Serotonergic modulation of cortical rat noradrenergic system in the mechanism of action of antidepressant drugs. Psychopharm. Bull., 21, 379–384.Google Scholar
  5. Brunello, N., Volterra, A., Cagiano, R., Ianieri, G.C., Cuomo, V., and Racagni, G. (1985b). Biochemical and behavioural changes after prolonged treatment with desimipramine: interaction with p-chlorophenylalanine. Naunyn-Schmiedeberg’s Arch. Pharmacol., 331, 20–22.Google Scholar
  6. Bylund, D.B., and Snyder, S.H. (1976). Beta-ad:„nergic receptor binding in membrane preparations from mammalian brain. Mol. Pharmacol., 12, 568–580.Google Scholar
  7. Habert, E., Graham, D., Tahoui, L., Claustre, Y., Langer, S.Z. (1985). Characterization of H-paroxetine binding to rat cortical membranes. Eur. J. Pharmacol., 118, 107–114.CrossRefGoogle Scholar
  8. Hirata, F., and Axelrod, J., (1980). Phospholipid methylation and the transmission of biological signals through membranes. Sciences, 209, 1082–1090.CrossRefGoogle Scholar
  9. Janowsky, A., Okada, F., Manier, D.H., Steranka, L., and Sulser, F. (1982). Role of serotonergic input in the regulation of the beta-adrenoceptor coupled adenylate cyclase system. Science, 218, 900–901.CrossRefGoogle Scholar
  10. Leysen, J.E., Niemegeers, C.J.E., Van Nueten, J.M., and Laduron, P.M. (1982). H-Ketanserin (R 41468), a selective H-ligand for serotonin-2 receptor binding sites: binding properties, brain distribution and functional role. Mol. Pharmacol., 21, 301–314.Google Scholar
  11. Racagni, G., Mocchetti, I., Calderini, G., Battistella A., and Brunello, N., (1983). Temporal sequence of changes in central noradrenergic system of rat after prolonged antidepressant treatment: receptor desensitization and neurotransmitter interactions. Neuropharmacology, 22, 415–424.CrossRefGoogle Scholar
  12. Racagni, G., and Brunello, N. (1984). Transynaptic mechanisms in the action of antidepressant drugs. Trends Pharmacol. Sci., 5, 527–531.Google Scholar
  13. Racagni, G., Brunello, N., Mocchetti, I., Cagiano, R., and Cuomo, V. (1985). Presynaptic and transynaptic mechanisms involved in the subsensitivity of rat cortical noradrenergic system after long-term antidepressant treatment. Acta Pharmacol. and Toxicol., 56 (Suppl. 1), 190–197.CrossRefGoogle Scholar
  14. Raisman, R., Briley, M., and Langer, S.Z. (1980). Specific tricyclic antidepr 3 sant binding sites in rat brain characterized by high affinity H-imipramine binding. Eur. J. Pharmacol., 61, 373–380.CrossRefGoogle Scholar
  15. Sugrue, M. (1983). Chronic antidepressant therapy and associated changes in central monoaminergic receptor functioning. Pharmac. Ther., 21, 1–33.CrossRefGoogle Scholar
  16. Sulser, F., Vetulani, J., and Mobley, P.L. (1978). Mode of action of antidepressant drugs. Biochem. Pharmacol., 27, 257–261.CrossRefGoogle Scholar
  17. Vetulani, J., and Sulser, F. (1975). Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic-AMP generating system in limbic forebrain. Nature, 257, 495–496.CrossRefGoogle Scholar
  18. Wolfe, B.B., Harden, T.K., Sporn, J.R., and Molinoff, P.B. (1978). Presynaptic modulation of beta-adrenergic receptors in rat cerebral cortex after treatment with antidepressant. J. Pharmacol. Exp. Ther., 207, 446–457.Google Scholar

Copyright information

© The Wenner-Gren Center 1987

Authors and Affiliations

  • N. Brunello
  • U. Cicerano
  • A. C. Rovescalli
  • M. Riva
  • R. Galimberti
  • C. Franzetti
  • G. Racagni

There are no affiliations available

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