Multiple Transduction Mechanisms for Dopamine D2 Receptors in Anterior Pituitary Cells

  • M. Memo
  • C. Missale
  • P. F. Spano
Part of the Wenner-Gren Center International Symposium Series book series (WGCISS)


A large body of experimental evidence points to the existence of multiple classes of dopamine (DA) receptors in mammalian brain and peripheral tissues which can be distinguished by their pharmacological specificity and localization and by their transduction mechanisms (Spano et al., 1978; Kebabian and Calne, 1979). Specifically, two types of DA receptors whose stimulation affects cellular cyclic AMP have been recently characterized. Stimulation of the so-called Dl DA receptors increases cyclic AMP formation, whereas stimulation of the D2 DA receptors reduces the formation of cyclic AMP (Spano et al., 1978; Stoof and Kebabian, 1981). Recent observations, however, rise the question whether the transduction mechanism of the DA signal may involve second messengers other than cyclic AMP (Simmonds and Strange, 1985; Memo et al, 1986). The studies on the transduction mechanisms induced by DA receptor stimulation have taken great advantage from the identification in the anterior pituitary of a single class of DA receptors, i.e. the D2 type (Spano et al., 1978; Caron et al., 1978).Since this peculiar property, the anterior pituitary has been taken as a viable model for studying both intracellular modifications and functional expression induced by D2 DA receptor stimulation.


Adenylate Cyclase Vasoactive Intestinal Peptide Calcium Influx Pituitary Cell Anterior Pituitary Cell 
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Copyright information

© The Wenner-Gren Center 1987

Authors and Affiliations

  • M. Memo
  • C. Missale
  • P. F. Spano

There are no affiliations available

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