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New Paradigm: Autonomic Neurotransmission by Multiple Interaction between Sites Intermittently Secreting Single Mixed Quanta

  • Lennart Stjärne
Part of the Wenner-Gren Center International Symposium Series book series (WGCISS)

Abstract

Recent findings by novel techniques severely challenge so many key aspects of earlier models of autonomic neurotransmission (Burnstock, 1986a) that mere revision is not enough — an entirely new paradigm is required (Stjärne, 1986,1987). The present paper describes the microanatomical aspects of the new model as applied to the guinea-pig and mouse vas deferens. These tissues are selected for two reasons: First, they are uniquely well suited for combined biochemical and electrophysiological analysis of the secretory activity in single sympathetic nerve varicosities (Blakeley and Cunnane, 1979; Stjärne, 1985). Second, since their smooth muscle cells have a dual autonomic innervation (Burnstock, 1970) they permit study of interactions between the sympathetic and parasympathetic nervous control of smooth muscle. Due to the limited space the discussion is brief and references are often given to review articles rather than to original papers.

Keywords

Sympathetic Nerve Contractile Response Single Quantum Parasympathetic Nerve Transmitter Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© The Wenner-Gren Center 1987

Authors and Affiliations

  • Lennart Stjärne

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