Interactions between the Modulator Adenosine and Classical Transmitters
There is continuous formation of adenosine in all cells. Methyltransferase reactions lead to the formation of S-adenosylhomocysteine, which is rapidly broken down to form adenosine. The rate of adenosine formation is markedly enhanced by any procedure that leads to a dissociation between the rate of ATP-production and the rate of ATP-utilization. Thus, adenosine levels rapidly increase in tissues whenever there is a threatening depletion of high-energy phosphate compounds from any of the cells in the tissue. Adenosine may be thought of as a signal of the metabolic state of a tissue or a group of cells.
KeywordsJurkat Cell Adenosine Receptor Phorbol Ester Pertussis Toxin Inositol Trisphosphate
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- Fredholm, B.B. (1982). Adenosine receptors. Med. Biol., 60, 289–293.Google Scholar
- Fredholm, B.B., Lindgren, E. and Lindström, K. (1985). Treatment with N-ethylmaleimide selectively reduces adenosine receptor mediated decreases in cyclic AMP accumulation in rat hippocampal slices. Br. J. Pharmacol., 86, 509–513.Google Scholar
- Fredholm, B.B., Gustafsson, L.E., Hedqvist, P. and Sollevi, A. (1983). Adenosine in the regulation of neurotransmitter release in the peripheral nervous system. In Regulatory Function of Adenosine. Developments in Pharmacology 2. (eds. R.M. Berne, T.W. Rall and R. Rubio). Martinus Nijhoff Publishers, The Hague.Google Scholar
- Katada, T., Gilman, A.G., Watanabe, Y., Bauer, S. and Jakobs, K.H. (1985). Protein kinase C phosphorylates the inhibitory guaninenucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase. Eur. J. Biochem., 151, 431–437.CrossRefGoogle Scholar
- Nordstedt, C. and Fredholm, B.B. (1986). Phorbol-12,13-dibutyrate enhances the cyclic AMP accumulation in rat hippocampal slices induced by adenosine analogues. Naunyn-Schmiedeberg’s Arch. Pharmacol, in press.Google Scholar
- O’Flynn, K., Russul-Saib, M., Ando, I., Wallace, D.L., Beverley, P.C.L., Boylston, A.W. and Linch, D.C. (1986). Different pathways of human T-cell activation revealed by PHA-P and PHA-M. Immunology, 57, 55–60.Google Scholar