Interactions between Vasoactive Intestinal Peptide and Norepinephrine, Ergot Alkaloids and Prostanoids in Mouse Cerebral Cortex
There is growing evidence that two, or possibly more, neurotransmitters can coexist within the same neuron (Hökfelt et al., 1980). In particular, the presence of a peptide and a biogenic amine has been demonstrated in the same terminals of central and peripheral neurons (Hökfelt et al., 1980). These findings have led to the hypothesis that neurotransmitters, coexisting within the same neurons, can interact at pre- or postsynaptic sites in a functionally coordinated manner. Interactions between neurotransmitters contained in distinct neuronal systems terminating within the same region of the central nervous system (CNS) can also be envisaged. We have examined this last possibility in the cerebral cortex, an area of the CNS where the two neurotransmitters vasoactive intestinal polypeptide (VIP) and norepinephrine (NE) are contained in separate neuronal systems and where they both stimulate the formation of cAMP (Morrison and Magistretti, 1983; Magistretti, 1986a,b).
KeywordsVasoactive Intestinal Peptide cAMP Level Vasoactive Intestinal Polypeptide Ergot Alkaloid Locus Coeruleus Neuron
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