Abstract
Apart from their classical action through the genetic protein synthesizing system, estrogens have been shown to influence the electrophysiological properties of both neuronal (Dufy et al., 1976 ; Moss & Dudley, 1984) and non neuronal cell types (Dufy & Vincent, 1980). Direct effects of 17 β -estradiol on membrane excitability have been demonstrated by intracellular recordings in rat medial amygdala brain slices (Nabekura et al., 1986). These rapid estrogen effects on membrane potential had already been described on GH3/B6 cells, a tumoral cell line of pituitary cells which releases prolactin (PRL) in response to estrogen stimulation (Dufy et al., 1979). Since they exhibit membrane excitability comparable to that observed in neurons, PRL secreting cells in culture offer us an accessible model to study the effect of estrogen on electrophysiological properties of cells. Some of our observations from tumoral and normal rat PRL cells will be given in this report.
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Vincent, J.D., Demotes-Mainard, J., Arnauld, E., Israel, J.M. (1987). Effects of Estrogens on the Electrophysiological Properties of Neurons and Adenohypophyseal Cells: Interactions with Dopamine. In: Fuxe, K., Agnati, L.F. (eds) Receptor-Receptor Interactions. Wenner-Gren Center International Symposium Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5415-4_11
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DOI: https://doi.org/10.1007/978-1-4684-5415-4_11
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