Estrogenic and Antiestrogenic Modulation of Neuronal Membrane Sensitivity

  • Robert L. Moss
  • Carol A. Dudley
  • Yang-In Kim
  • Misty Eaton
Part of the Wenner-Gren Center International Symposium Series book series (WGCISS)


Although studies on the action of steroids on the central nervous system (CNS) have a long history, the discovery of estradiol-concentrating neurons in the brain greatly accelerated experiments designed to determine the electrophysiological consequences of estradiol administration at the level of the single brain cell (For review see Morrell et al., 1984; Moss & Dudley, 1984). The utilization of the in vitro slice preparation as well as the application of estrogen directly to the neuronal membrane in vivo has contributed enormously to our understanding of the cellular mechanism(s) of steroid actions in the brain. The aim of this presentation is twofold: the first is to provide a brief review of the actions of estrogen on CNS neuronal activity and the second aim is to present some new contributions concerning the mechanism(s) by which estrogen affects neuronal activity.


Firing Rate Neuronal Membrane Hypothalamic Neuron Slice Preparation Strip Chart Record 
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© The Wenner-Gren Center 1987

Authors and Affiliations

  • Robert L. Moss
  • Carol A. Dudley
  • Yang-In Kim
  • Misty Eaton

There are no affiliations available

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