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Reactions to Benzodiazepines

  • Frank L. Tornatore
  • John J. Sramek
  • Bette L. Okeya
  • Edmond H. Pi

Abstract

The emergence of hostile reactions may involve increased verbal hostility and even physical assault. Often this behavior appears to be triggered by some frustrating stimulus before the patient “lashes out.” Some patients describe being very restless and pace the room before losing control.

Keywords

Myocardial Blood Flow Total Peripheral Resistance Paradoxical Reaction Female Orgasm Withdrawal Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Suggested Readings

  1. Goldney, R. D.: Paradoxical reaction to a new minor tranquilizer. Med J Aust 1:139–140, 1977.PubMedGoogle Scholar
  2. Lion J. R.: Benzodiazepines in the treatment of aggressive patients. J Clin Psychiatry 40:70–71, 1979.PubMedGoogle Scholar
  3. Rosenbaum J. F., Woods S. W., Groves J. E.: Emergence of hostility during alprazolam treatment. Am J Psychiatry 141:792–793, 1984.PubMedGoogle Scholar
  4. Bliwise D., Seidel W., Karacan I., et al: Daytime sleepiness as a criterion in hypnotic medication trials: Comparison of triazolam and flurazepam. Sleep 6:156–163, 1983.PubMedGoogle Scholar
  5. Greenblatt D. J., Shader R. I., Abernethy D. R.: Current status of benzodiazepines (second of two parts). N Engl J Med 300:410–416, 1983.Google Scholar
  6. Cote P., Gueret P., Bourassa M. G.: Systemic and coronary hemodynamic effects of diazepam in patients with normal and diseased coronary arteries. Circulation 50:1210–1216, 1974.PubMedGoogle Scholar
  7. Elliott H. W., Nomof N., Navarro G., Ruelius H. W., Knowles J. A., Corner W. H.: Central nervous system and cardiovascular effects of lorazepam in man. Clin Pharmacol Ther 12:468–481, 1971.PubMedGoogle Scholar
  8. Greenblatt D. J., Shader R. I.: Benzodiazepines (first of two parts). N Engl J Med 291(19):1011–1015, 1974.CrossRefGoogle Scholar
  9. Ikram H., Rubin A. P., Jewkes R. F.: Effect of diazepam on myocardial blood flow of patients with and without coronary artery disease. Br Heart J 35:626–630, 1973.PubMedCrossRefGoogle Scholar
  10. Keim K. L., Sigg E. B.: Vagally mediated cardiac reflexes and their modulation by diazepam and pentobarbital. Neuropharmacology 10:319–321, 1973.CrossRefGoogle Scholar
  11. Markiewicz W., Hunt S., Harrison D. C., Alderman E. L.: Circulatory effects of diazepam in heart disease. J Clin Pharmacol 16:637–644, 1976.PubMedGoogle Scholar
  12. Rao S., Sherbaniuk R. W., Prassad K., Lee S. J. K., Sproule B. J.: Cardiopulmonary effects of diazepam. Clin Pharmacol Ther 14:185–189, 1973.Google Scholar
  13. Valium: A monograph. Roche Laboratories, Nutley, New Jersey, 1980.Google Scholar
  14. Wagner B. C., McIntosh H. D.: The use of drugs in achieving successful DC cardioversion. Prog Cardiovasc Dis 11:431–442, 1969.PubMedCrossRefGoogle Scholar
  15. Clergue F., Desmonts J. M., Duvaldestin P., Delavault E., Saumon G.: Depression of respiratory drive by diazepam as premedication. Br J Anaesthesia 53:1059–1063, 1981.CrossRefGoogle Scholar
  16. Greenblatt D. J., Shader R. I.: Benzodiazepines (first of two parts). N Engl J Med 291:1011–1015, 1974.PubMedCrossRefGoogle Scholar
  17. Markiewicz, W., Hunt S., Harrison D. C., Alderman E. L.: Circulatory effects of diazepam in heart disease. J Clin Pharmacol 16:637–644, 1976.PubMedGoogle Scholar
  18. McClish A.: Diazepam as an intravenous agent for general anesthesia. Can Anaesthesiol Soc J 13:562–575, 1966.CrossRefGoogle Scholar
  19. Paulson B. A., Becher L. D., Way W. L.: The effects of intravenous lorazepam alone and with meperidine on ventilation in man. Acta Anaesthesiol Scand 27:400–402, 1983.PubMedCrossRefGoogle Scholar
  20. Rao, S., Sherbaniuk R. W., Prssad K., Lee S. J. K., Sproule B. J. L.: Cardiopulmonary effects of diazepam. Clin Pharmacol Ther 14:182–189, 1973.PubMedGoogle Scholar
  21. Valium: A monograph. Roche Laboratories, Nutley, New Jersey, 1980.Google Scholar
  22. Weber L. W. D.: Benzodiazepines in pregnancy—Academic debate or teratogenic risk? Biol Res Pregnancy Perinatol 6(4):151–167, 1985.PubMedGoogle Scholar
  23. Briggs G. G., Bodendorfer T. W., Freeman R. K.: in Drugs in Pregnancy and Lactation. Baltimore, Williams & Wilkins, 1983.Google Scholar
  24. Onnis A., Grella P.: in The Biochemical Effects of Drugs in Pregnancy, Vol I. Ellis Horwood, 1984.Google Scholar
  25. Rosenberg L.: Lack of relation of oral clefts to diazepam use during pregnancy. N Eng J Med 309:1282, 1983.CrossRefGoogle Scholar
  26. Csernansky J. G., Hollister L. E.: Withdrawal reaction following therapeutic doses of benzodiazepines. Hosp Formulary 18:900–902, 1983.Google Scholar
  27. Dietch h J.: The nature and extent of benzodiazepine abuse: An overview of recent literature. Hosp Community Psychiatry 34:1139–1145, 1983.PubMedGoogle Scholar
  28. Dominguez R. O., Goldstein B. J.: 25 years of benzodiazepine experience: Clinical commentary on use, abuse, and withdrawal. Hosp Formulary 20:1000–1014, 1985.Google Scholar
  29. Harrison, M.: Diazepam tapering in detoxification for high-dose benzodiapezine abuse. Clin Pharmacol Ther 36:527–533, 1984.PubMedCrossRefGoogle Scholar
  30. Kales A., Scharf M. B., Kales J. D., et al: Rebound insomnia: A potential hazard following withdrawal of certain benzodiazepines. J Am Med Assoc 241:1692–1695, 1979.CrossRefGoogle Scholar
  31. Lader M., Higgitt A.: Management of withdrawal from benzodiazepines. Jnt Drug Ther Newsl 21(6):21–24, 1986.Google Scholar
  32. Noyes R., Perry P. J., Crowe R. R., et al: Seizures following the withdrawal of alprazolam. J New Ment Dis 174:50–52, 1986.CrossRefGoogle Scholar
  33. Rickels K., Case W. G., Downing R. W.: Issues in long-term treatment with diazepam. Psychopharmacol Bull 18:38–41, 1982.Google Scholar

Miscellaneous Effects

  1. Mac D. S., Kumar R., Goodwin D. W.: Anteriograde amnesia with oral lorazepam. J Clin Psychiatry 46:137–138, 1985.PubMedGoogle Scholar
  2. Ejaculatory inhibition: In a case report of a 47-yr-old male, when the dose of alprazolam was increased to 1.5 mg TID, the patient reported an inability to ejaculate. The possible mechanisms for this reaction are discussed.Google Scholar
  3. Munjack D. J., Crocker B.: Alprazolam-induced ejaculatory inhibition (letter). J Clin Psychopharmacol 6(1):57–58, 1986.PubMedCrossRefGoogle Scholar
  4. Am J Psychiatry 142:1223–1224, 1985.Google Scholar
  5. Straham A., Rosenthal J., Kaswar M., et al: Three case reports of acute paroxysmal excitement associated with alprazolam treatment. Am J Psychiatry 142:859–861, 1985.Google Scholar
  6. Rosenbaum J. F., Woods S. W., Groves J. E., et al: Emergence of hostility during alprazolam treatment. Am J Psychiatry 141:792–793, 1984.PubMedGoogle Scholar
  7. Arana G. W., Pearlman C., Shader R. J.: Alprazolam-induced mania: Two clinical cases. Am J Psychiatry 142:368–369, 1985.PubMedGoogle Scholar
  8. Pecknold J. C., Fleury D.: Alprazolam-induced manic episode in two patients with panic disorder. Am J Psychiatry 143:652–653, 1986.PubMedGoogle Scholar
  9. Elliot R. L., Thomas B. J.: A case report of alprazolam-induced stuttering. J Clin Psychopharmacol 5(3):159–160, 1985.CrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Frank L. Tornatore
    • 1
  • John J. Sramek
    • 2
  • Bette L. Okeya
    • 3
  • Edmond H. Pi
    • 4
  1. 1.University of Southern California School of PharmacyLos AngelesUSA
  2. 2.Clinical Research UnitMetropolitan State HospitalNorwalkUSA
  3. 3.Department of Pharmaceutical ServicesUCLA Medical Center and Neuropsychiatric InstituteLos AngelesUSA
  4. 4.Department of PsychiatryUniversity of Southern California School of MedicineLos AngelesUSA

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