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The Involvement of the T-Cell Receptor in Chromosomal Aberrations

  • Ilan R. Kirsch
  • Gregory F. Hollis

Abstract

It is now clear that the T-cell receptor gene loci are directly involved in some of the most characteristic chromosomal aberrations specifically associated with T-cell disorders. This recent conclusion, however, should be viewed in the general context of the genesis of cell-type-specific chromosomal abnormalities. Over the past 25 years cytogeneticists have been describing an ever-increasing number of distinctive chromosomal abnormalities specifically associated with certain types of cancer (Yunis et al., 1983). We are not speaking of the constitutional syndromes of karyotype abnormality (e.g., trisomy 21) found in every cell of an affected individual, which are believed to predispose the person to the development of certain cancers. Rather we are considering here those chromosomal abnormalities found only in the tumors of an otherwise karyotypically normal person. One of the earliest identified and best known associations is the occurrence of the reciprocal translocation between chromosomes 9 and 22 yielding as one of the derivative partners the so-called “Philadelphia” chromosome seen in over 95% of the tumors of patients with chronic myelogenous leukemia (Noweli and Hungerford, 1960; Rowley, 1980). Other different, but consistent chromosomal aberrations have now been reported for Burkitt’s lymphoma (Zech et al., 1976), a spectrum of additional hematopoietic malignancies (Chaganti, 1983), as well as a number of solid tumors (Yunis et al., 1983).

Keywords

Chromosomal Aberration Karyotypic Abnormality Immunoglobulin Heavy Chain Gene Prolymphocytic Leukemia Human Lymphocyte Culture 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Ilan R. Kirsch
    • 1
  • Gregory F. Hollis
    • 2
  1. 1.National Cancer Institute-Navy Medical Oncology Branch, National Cancer InstituteNational Institutes of HealthBethesdaUSA
  2. 2.Monsanto Co.St. LouisUSA

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