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The Structure and Expression of the T-Cell α-, β-, and γ-Chain Genes in Human Malignancies

  • J. Slingerland
  • H. Griesser
  • T. W. Mak
  • M. D. Minden

Abstract

An essential feature of the malignant state is the clonal expansion of a single cell (Fialkow, 1976). This discovery has had a great impact upon our understanding of the development and progression of tumors. The presence of a clonal population of cells often has been ascertained by the detection of acquired karyotypic abnormalities in the malignant cells (Rowley, 1978), or the altered pattern of expression of the enzyme G-6-PD in appropriate heterozygous females (Fialkow, 1976). The introduction of the techniques of molecular biology has provided the investigator with a number of other means for detecting clonal populations of malignant cells (Korsmeyer et al., 1983); this has been amply demonstrated for malignancies involving lymphocytes (Korsmeyer et al., 1983; Arnold et al., 1983; Sklar et al., 1984). In this review we will describe the genes and the probes that have been used to determine the clonal nature of malignancies involving T lymphocytes and indicate, where possible, how these studies have altered our understanding of these diseases.

Keywords

Gene Rearrangement Acute Myeloblastic Leukemia Cell Antigen Receptor Clonal Rearrangement Cell Receptor Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • J. Slingerland
    • 1
  • H. Griesser
    • 1
  • T. W. Mak
    • 1
  • M. D. Minden
    • 1
  1. 1.Departments of Medicine and Medical Biophysics, Ontario Cancer InstituteUniversity of TorontoTorontoCanada

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