Role of the T3/T-Cell Antigen Receptor Complex in T-Cell Activation
Interactions that occur at the interface of the plasma membranes of T cells and antigen-presenting cells (or target cells) initiate events that culminate in T-cell activation. Activation may be manifested by the production of lymphokines, appearance of new cell surface antigens (such as the IL-2 receptor) and, ultimately, in T-cell proliferation. The T-cell antigen receptor (Ti) plays a central role in this interaction and has two functions: First, it must subserve a cognitive function, recognizing antigen in the context of the major histocompatibility complex (MHC). Secondly, it must convert such a recognition event into a transmembrane signal which can initiate T-cell activation. This chapter will focus on this second role of Ti in initiating human T-cell activation.
KeywordsJurkat Cell Phorbol Myristate Acetate Antigen Receptor Calcium Ionophore Phorbol Myristate Acetate
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