The T-Cell Receptor/T3 Complex on the Surface of Human and Murine T Lymphocytes

  • Cox Terhorst
  • Benjamin Berkhout
  • Balbino Alarcon
  • Hans Clevers
  • Katia Georgopoulos
  • Daniel Gold
  • Hans Oettgen
  • Carolyn Pettey
  • Peter Van Den Elsen
  • Tom Wileman


Thymus-derived lymphocytes (T cells) are essential in the protection of vertebrates from environmental pathogens. As effector cells, they serve to recognize and eliminate cells bearing infectious agents and tumor antigens. In addition, they play a major role in the functional regulation of the immune response. Unlike B lymphocytes, which mediate their antigen-specific functions via secreted or membrane bound immunoglobulins that can bind to soluble ligands, T cells are responsive only to cell-surface antigens. Specifically, T-lymphocyte membrane receptors recognize antigen presenting cells (APCs), which express the autologous class I or class II integral membrane protein products of the major histocompatibility complex (MHC). This interaction between cells can lead to a variety of responses by the antigen-specific T lymphocytes, including proliferation, production of lymphokines, and target cell cytolysis.


Major Histocompatibility Complex Antigen Receptor Major Histocompatibility Complex Antigen Immunoglobulin Supergene Family Intrathymic Differentiation 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Cox Terhorst
    • 1
  • Benjamin Berkhout
    • 1
  • Balbino Alarcon
    • 1
  • Hans Clevers
    • 1
  • Katia Georgopoulos
    • 1
  • Daniel Gold
    • 1
  • Hans Oettgen
    • 1
  • Carolyn Pettey
    • 1
  • Peter Van Den Elsen
    • 1
  • Tom Wileman
    • 1
  1. 1.Laboratory of Molecular Immunology, Dana Farber Cancer InstituteHarvard Medical SchoolBostonUSA

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