Ion Transport by Gastric Mucosa

  • John G. Forte
  • Terry E. Machen


The stomach serves important alimentary functions, as an organ for food storage and in providing the secretory juices that serve to initiate the digestive process. These functions are carefully regulated by neural and hormonal mechanisms to liquify, sterilize, macerate, and partially degrade the components of a meal. The heavy muscular wall of the stomach provides the peristaltic mixing waves, while the epithelial cells of the gastric mucosa supply the secretory products of the juice. Gastric secretory products can conveniently be subdivided into a mucus component, principally serving a lubricating function, an enzyme component, in the form of the enzyme precursor pepsinogen, and an aqueous component, which largely consists of hydrochloric acid. The purpose of this chapter is to review the mechanisms responsible for the secretion of the ions and water that constitute the so-called aqueous component of gastric juice. We will focus our discussion on those ion transport processes that are directly or indirectly related to HCl secretion.


Gastric Mucosa Apical Membrane Basolateral Membrane Gastric Gland Frog Skin 
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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • John G. Forte
    • 1
  • Terry E. Machen
    • 1
  1. 1.Department of Physiology-AnatomyUniversity of CaliforniaBerkeleyUSA

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