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Transport Functions of the Distal Convoluted Tubule

  • Linda S. Costanzo
  • Erich E. Windhager

Abstract

The distal convoluted tubule (DCT) has traditionally been described as the nephron segment extending from the macula densa the first confluence with another DCT to form a collecting tubule. Virtually all data on DCT function derive from in vivo studies in the rat using micropuncture or microperfusion techniques. Rat DCT are 2.4–2.5 mm in length(1, 2) They can be identified on the kidney surface with light microscopy by their contrast to proximal tubules: the lumina are narrower and the contour more irregular than in proximal tubules. Distal tubulai epithelium lacks a brush border and therefore fails to exhibit the light reflex seen in proximal tubules.(3) Eighty percent of the rar DCT is accessible to micropuncture, with only the initial 20% below the kidney surface. At present, the rat provides the most convenient model for studies of DCT function. While the in vitrc perfused rabbit nephron technique has been applied extensivery to study the function of other tubular segments, the technique is not readily applied to the DCT because of its short length in the rabbit.

Keywords

Distal Tubule Distal Convoluted Tubule Luminal Membrane Nephron Segment Tubular Fluid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Linda S. Costanzo
    • 1
  • Erich E. Windhager
    • 2
  1. 1.Department of Physiology and BiophysicsMedical College of VirginiaRichmondUSA
  2. 2.Department of PhysiologyCornell University Medical CollegeNew YorkUSA

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