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The Proximal Nephron

  • Gerhard Giebisch
  • Peter S. Aronson
Chapter

Abstract

This chapter deals with an analysis of proximal tubular fluid and electrolyte transport. The proximal tubule of the mammalian kidney is the nephron site where the major portion, some two-thirds to three-fourths, of the filtered sodium salts is reabsorbed. The unique importance of this transport operation derives from the fact that this active, energy-consuming transport process provides the main driving force for transepithelial water movement/12) Thus, the maintenance of an adequate and constant extracellular fluid and plasma volume depends crucially on the integrity of the proximal tubular Na+ transport system. This is not to ignore the fact that distal portions of the nephron may enhance their rate of Na+ and fluid transport when Na+ and fluid escape proximal reabsorption, and that the fine adjustment of salt and water balance is regulated within the distal nephron. Nevertheless, it is at the proximal tubular level where the bulk of water, salts, and nonelectrolytes are normally retrieved from the filtrate.

Keywords

Proximal Tubule Basolateral Membrane Proximal Tubule Cell Proximal Convoluted Tubule Luminal Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Gerhard Giebisch
    • 1
  • Peter S. Aronson
    • 2
  1. 1.Department of PhysiologyYale University School of MedicineNew HavenUSA
  2. 2.Departments of Physiology and Internal MedicineYale University School of MedicineNew HavenUSA

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