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The Regulation of Glomerular Filtration Rate in Mammalian Kidneys

  • L. Gabriel Navar
  • P. Darwin Bell
  • Andrew P. Evan

Abstract

During organogenesis of the kidney, small S-shaped meta-nephric vesicles form from the undifferentiated metanephric mesoderm. The cephalic part of each primitive renal tubule in-vaginates to form a cleft within which mesenchymal cells, destined to become the mesangium, accumulate. The formation of a continuous basement membrane serves to separate the intra-cleftal mesenchymal cells from the tubular cells. As the mesenchymal cells increase in number, vascular tissue enters the cleft to form the capillaries of the glomerular tuft. Eventually, the spherical glomerular capsule is formed and encloses the capillaries, leaving the afferent and efferent arterioles to maintain continuity with the vascular system.

Keywords

Afferent Arteriole Colloid Osmotic Pressure Efferent Arteriole Tubuloglomerular Feedback Glomerular Capillary Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • L. Gabriel Navar
    • 1
  • P. Darwin Bell
    • 1
  • Andrew P. Evan
    • 2
  1. 1.Nephrology Research and Training Center and Department of Physiology and BiophysicsUniversity of Alabama School of MedicineBirminghamUSA
  2. 2.Department of AnatomyIndiana University Medical CenterIndianapolisUSA

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