The Regulation of Glomerular Filtration Rate in Mammalian Kidneys

  • L. Gabriel Navar
  • P. Darwin Bell
  • Andrew P. Evan


During organogenesis of the kidney, small S-shaped meta-nephric vesicles form from the undifferentiated metanephric mesoderm. The cephalic part of each primitive renal tubule in-vaginates to form a cleft within which mesenchymal cells, destined to become the mesangium, accumulate. The formation of a continuous basement membrane serves to separate the intra-cleftal mesenchymal cells from the tubular cells. As the mesenchymal cells increase in number, vascular tissue enters the cleft to form the capillaries of the glomerular tuft. Eventually, the spherical glomerular capsule is formed and encloses the capillaries, leaving the afferent and efferent arterioles to maintain continuity with the vascular system.


Afferent Arteriole Colloid Osmotic Pressure Efferent Arteriole Tubuloglomerular Feedback Glomerular Capillary Pressure 
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  1. 1.
    DuBois, A. M., C. Rouiller, and A. F. Müller. 1969. The embryonic kidney. In: The Kidney: Morphology, Biochemistry, Physiology, Volume I. Academic Press, New York. pp. 1–50.Google Scholar
  2. 2.
    McCrory, W. W. 1972. Developmental Nephrology. Harvard University Press, Cambridge, Mass. pp. 1–50.Google Scholar
  3. 3.
    Oliver, J. 1968. Nephrons and Kidneys. Harper & Row, New York. pp. 47–50.Google Scholar
  4. 4.
    Renkin, E. M., and J. P. Gilmore. 1973. Glomerular filtration. In: Handbook of Physiology, Section 8. J. Orloff and R. W. Berliner, eds. American Physiological Society, Washington, D.C. pp. 185–248.Google Scholar
  5. 5.
    Kunkel, P. A. 1930. The number and size of the glomeruli in the kidney of several mammals. Bull. Johns Hopkins Hosp. 47:285–291.Google Scholar
  6. 6.
    Smith, H. W. 1951. The Kidney. Oxford University Press, London, pp. 562–574.Google Scholar
  7. 7.
    Aeikens, B., A. Eenboom, and A. Bohle. 1979. Untersuchungen zur Struktur des Glomerulum Rekonstruktion eines Ratten glomerulum am.5u dicken Serien schnitten. Virchows Arch. A 381:283–293.Google Scholar
  8. 8.
    Shea, S. M. 1979. Glomerular hemodynamics and vascular structure: The pattern and dimensions of a single rat glomerular capillary network reconstructed from ultrathin sections. Microvasc. Res. 18:129–143.PubMedCrossRefGoogle Scholar
  9. 9.
    Navar, L. G. 1978. The regulation of glomerular filtration rate in mammalian kidneys. In: Physiology of Membrane Disorders. T. E. Andreoli, J. Hoffman, and D. Fanestil, eds. Plenum Press, New York. pp. 593–626.CrossRefGoogle Scholar
  10. 10.
    Taugner, C., K. Poulsen, E. Hackenthal, and R. Taugner. 1979. Immunocytochemical localization of renin in mouse kidney. Histochemistry 62:19–27.PubMedCrossRefGoogle Scholar
  11. 11.
    Casellas, D., and A. Mimran. 1981. Shunting in renal micro-vasculature of the rat: A scanning electron microscopic study of corrosion casts. Anat. Rec. 201:237–248.PubMedCrossRefGoogle Scholar
  12. 12.
    Gattone, V. H., F. C. Luft, and A. P. Evan. 1984. The renal afferent and efferent arterioles of the rabbit. Am. J. Physiol. 247: F219–F228.PubMedGoogle Scholar
  13. 13.
    Barger, A. C., and J. A. Herd. 1973. Renal vascular anatomy and distribution of blood flow. In: Handbook of Physiology, Section 8. J. Orloff and R. W. Berliner, eds. American Physiological Society, Washington, D.C. pp. 249–313.Google Scholar
  14. 14.
    Beeuwkes, R., and J. V. Bonventre. 1975. Tubular organization and vascular tubular relations in the dog kidney. Am. J. Physiol. 229:695–713.PubMedGoogle Scholar
  15. 15.
    Evan, A. P., and W. G. Dail. 1977. Efferent arterioles in the cortex of the rat kidney. Anat. Rec. 187:135–145.PubMedCrossRefGoogle Scholar
  16. 16.
    Weinstein, S. W., and J. Szyjewicz. 1978. Superficial nephron tubular-vascular relationships in the rat kidney. Am. J. Physiol. 234:F207–F214.PubMedGoogle Scholar
  17. 17.
    Rouiller, C., and L. Orci. 1971. The structure of the juxtaglomerular complex. In: The Kidney: Morphology, Biochemistry, Physiology, Volume IV. C. Rouiller and A. F. Muller, eds. Academic Press, New York. pp. 1–80.Google Scholar
  18. 18.
    Barajas, L., and J. Müller. 1973. The innervation of the juxtaglomerular apparatus and surrounding tubules: A quantitative analysis by serial sections electron microscopy. J. Ultrastruct. Res. 43:107–132.PubMedCrossRefGoogle Scholar
  19. 19.
    Kaissling, B., S. Peter, and W. Kriz. 1977. The transition of the thick ascending limb of Henle’s loop into the distal convoluted tubule in the nephron of the rat kidney. Cell Tissue Res. 182:111–118.PubMedCrossRefGoogle Scholar
  20. 20.
    Pricam, C., F. Humbert, A. Perrelet, and L. Orci. 1974. Gap junctions in mesangial and lacis cells. J. Cell Biol. 63:349–354.PubMedCrossRefGoogle Scholar
  21. 21.
    Taugner, R., A. Schiller, B. Kaissling, and W. Kriz. 1978. Gap junctional coupling between the J.G.A. and the glomerular tuft. Cell Tissue Res. 186:279–285.PubMedCrossRefGoogle Scholar
  22. 22.
    Kaissling, B., and W. Kriz. 1982. Variability of intercellular spaces between macula densa cells: A transmission electron microscopic study in rabbits and rats. Kidney Int. 22:S9–S17.Google Scholar
  23. 23.
    Spanidis, A., H. Wunsch, B. Kaissling, and W. Kriz. 1982. Three-dimensional shape of a Goormaghtigh cell and its contact with a granular cell in the rabbit kidney. Anat. Embryol. 165:239-252VGoogle Scholar
  24. 24.
    Latta, H. 1973. Ultrastructure of the glomerulus and juxtaglomerular apparatus. In: Handbook of Physiology, Section 8. J. Orloff and R. W. Berliner, eds. American Physiological Society, Washington, D.C. pp. 1–29.Google Scholar
  25. 25.
    Navar, L. G., A. P. Evan, and L. Rosivall. 1983. Microcirculation of the kidneys. In: The Physiology and Pharmacology of the Microcirculation, Volume I. N. Mortillaro, ed. Academic Press, New York. pp. 397–488.Google Scholar
  26. 26.
    Davis, J. O., and R. H. Freeman. 1976. Mechanisms regulating renin release. Physiol. Rev. 56:1–56.PubMedGoogle Scholar
  27. 27.
    Vander, A. J. 1967. Control of renin release. Physiol. Rev. 47:359–382.PubMedGoogle Scholar
  28. 28.
    Wright, F. S., and J. B. Briggs. 1979. Feedback control of glomerular blood flow, pressure, and filtration rate. Physiol. Rev. 59:958–1006.PubMedGoogle Scholar
  29. 29.
    Schnermann, J. 1981. Localization, mediation and function of the glomerular vascular response to alterations of distal fluid delivery. Fed. Proc. 40:109–115.PubMedGoogle Scholar
  30. 30.
    Navar, L. G., D. W. Ploth, and P. D. Bell. 1980. Distal tubular feedback control of renal hemodynamics and autoregulation. Annu. Rev. Physiol. 42:557–571.PubMedCrossRefGoogle Scholar
  31. 31.
    Thurau, K., and J. Mason. 1974. The intrarenal function of the juxtaglomerular apparatus. In: Kidney and Urinary Tract Physiology. K. Thurau, ed. University Park Press, Baltimore, pp. 357–389.Google Scholar
  32. 32.
    Rovenska, E. 1983. Two types of capillaries in the rat renal glomerulus. Acta Anat. 115:31–39.PubMedCrossRefGoogle Scholar
  33. 33.
    Karnovsky, M. J. 1979. The ultrastructure of glomerular filtration. Annu. Rev. Med. 30:213–224.PubMedCrossRefGoogle Scholar
  34. 34.
    Andrews, P. M. 1981. Investigations of cytoplasmic contractile and cytoskeletal elements in the kidney glomerulus. Kidney Int. 20:549–562.PubMedCrossRefGoogle Scholar
  35. 35.
    Larsson, L., and A. B. Maunsbach. 1980. The ultrastructural development of the glomerular filtration barrier in the rat kidney: A morphometric analysis. J. Ultrastruct. Res. 72:392–406.PubMedCrossRefGoogle Scholar
  36. 36.
    Mohos, S. C., and L. Skoza. 1970. Histochemical demonstration and localization of sialoproteins in the glomerulus. Exp. Mol. Pathol. 12:316–323.PubMedCrossRefGoogle Scholar
  37. 37.
    Kanwar, Y. S., and M. G. Farquhar. 1979. Presence of heparan sulfate in the glomerular basement membrane. Proc. Natl. Acad. Sci. USA 76:1303–1307.PubMedCrossRefGoogle Scholar
  38. 38.
    Roll, F. J., J. A. Madri, J. Albert, and H. Furthmayr. 1980. Codistribution of collagen types IV and AB2 in basement membranes and mesangium of the kidney: An immunoferritin study of ultrathin frozen sections. J. Cell Biol. 85:597–616.PubMedCrossRefGoogle Scholar
  39. 39.
    Madri, J. A., F. J. Roll, H. Furthmayr, and J. M. Foidart. 1980. Ultrastructural localization of fibronectin and laminin in the basement membranes of the murine kidney. J. Cell Biol. 86:682–687.PubMedCrossRefGoogle Scholar
  40. 40.
    Kanwar, Y. S., and M. G. Farquhar. 1979. Anionic sites in the glomerular basement membrane: In vivo and in vitro localization to the laminae rarae by cationic probes. J. Cell Biol. 81:137–153.PubMedCrossRefGoogle Scholar
  41. 41.
    Rennke, H. G., and M. A. Venkatachalam. 1977. Glomerular permeability: In vivo tracer studies with polyanionic and polyca-tionic ferritins. Kidney Int. 11:44–53.PubMedCrossRefGoogle Scholar
  42. 42.
    Gattone, V. H., A. P. Evan, S. A. Mong, B. A. Connors, G. R. Aronoff, and F. C. Luft. 1983. The morphology of the renal microvasculature in glycerol-and gentamicin-induced acute renal failure. J. Lab. Clin. Med. 101:183–195.PubMedGoogle Scholar
  43. 43.
    Avasthi, P. S., A. P. Evan, and D. Hay. 1980. Glomerular endothelial cells in uranyl nitrate induced acute renal failure in rats. J. Clin. Invest. 65:121–127.PubMedCrossRefGoogle Scholar
  44. 44.
    Michael, A. F., W. F. Keane, L. Ray, R. L. Vernier, and S. M. Mauer. 1980. The glomerular mesangium. Kidney Int. 17:141— 154.CrossRefGoogle Scholar
  45. 45.
    Sterzel, R. B., D. H. Lovett, H. D. Stein, and M. Kashgarian. 1982. The mesangium and glomerulonephritis. Klin. Wochenschr. 60:1077–1094.PubMedCrossRefGoogle Scholar
  46. 46.
    Kreisberg, J. I., and M. J. Karnovsky. 1983. Glomerular cells in culture. Kidney Int. 23:439–447.PubMedCrossRefGoogle Scholar
  47. 47.
    Bernik, M. B. 1969. Contractile activity of human glomeruli in culture. Nephron 6:1–10.PubMedCrossRefGoogle Scholar
  48. 48.
    Brown, G. P., J. G. Douglas, and J. Krontiris-Litowitz. 1980. Properties of angiotensin II receptors of isolated rat glomeruli: Factors influencing binding affinity and comparative binding of angiotensin analogs. Endocrinology 106:1923–1929.PubMedCrossRefGoogle Scholar
  49. 49.
    Ausiello, D. A., J. I. Kreisberg, C. Roy, and M. J. Karnovsky. 1980. Contraction of cultured rat glomerular cells of apparent mesangial origin after stimulation with angiotensin II and arginine vasopressin. J. Clin. Invest. 65:754–760.PubMedCrossRefGoogle Scholar
  50. 50.
    Barajas, L. 1978. Innervation of the renal cortex. Fed. Proc. 37:1192–1201.PubMedGoogle Scholar
  51. 51.
    DiBona, G. F. 1982. The functions of the renal nerves. Rev. Physiol. Biochem. Pharmacol. 94:76–181.Google Scholar
  52. 52.
    Dinerstein, R. J., J. Vannici, R. C. Henderson, L. J. Roth, L. I. Goldberg, and P. C. Hoffman. 1979. Histofluorescence techniques provide evidence for dopamine-containing neural elements in canine kidney. Science 205:497–499.PubMedCrossRefGoogle Scholar
  53. 53.
    Dieterich, H.J. 1974. Electron microscopic studies of the innervation of the rat kidney. Z. Anat. Entwicklungsgesch. 145:169–186.CrossRefGoogle Scholar
  54. 54.
    Landis, E. M., and J. R. Pappenheimer. 1963. Exchange of substances through the capillary walls. In: Handbook of Physiology, Volume II. American Physiological Society, Washington, D.C. pp. 961–1034.Google Scholar
  55. 55.
    Pappenheimer, J. R., E. M. Renkin, and CM. Borrero. 1951. Filtration, diffusion and molecular sieving through peripheral capillary membranes. Am. J. Physiol. 167:13–46.PubMedGoogle Scholar
  56. 56.
    Solomon, A. K. 1968. Characterization of biological membranes by equivalent pores. J. Gen. Physiol. S52:335–364.Google Scholar
  57. 57.
    Oken, D. E., and W. Flamenbaum. 1971. Micropuncture studies of proximal tubule albumin concentrations in normal and nephrotic rats. J. Clin. Invest. 50:1498–1505.PubMedCrossRefGoogle Scholar
  58. 58.
    Von Baeyer, H., J. B. VanLiew, J. Klassen, and J. W. Boylan. 1976. Filtration of protein in the anti-glomerular basement membrane nephritic rat: A micropuncture study. Kidney Int. 10:425–437.PubMedCrossRefGoogle Scholar
  59. 59.
    Oken, D. E., D. C. Mikulecky, G. K. Smith, and D. M. Landwehr. 1984. On the sieving of macromolecules by the glomerular basement membrane—Theoretical considerations of steric and charge properties. In: Proceedings of the International Symposium on Pathogenetic Role ofCationic Proteins with Biological Membranes. P. Bergmann, R. Beauwers, and P. P. Lambert, eds. Presses Universitaires de Bruxelles, Brussels.Google Scholar
  60. 60.
    Brenner, B. M., W. M. Deen, and C. R. Robertson. 1974. The physiological basis of glomerular ultrafiltration. In: Kidney and Urinary Tract Physiology. K. Thurau, ed. University Park Press, Baltimore, pp. 335–356.Google Scholar
  61. 61.
    Navar, P. D., and Navar, L. G. 1977. Relationship between colloid osmotic pressure and plasma protein concentration in the dog. Am. J. Physiol. 233:H295–H298.PubMedGoogle Scholar
  62. 62.
    Thomas, C. E., P. D. Bell, and L. G. Navar. 1979. Glomerular filtration dynamics in the dog during elevated plasma colloid osmotic pressure. Kidney Int. 15:502–512.PubMedCrossRefGoogle Scholar
  63. 63.
    Brenner, B. M., I. F. Ueki, and T. M. Daugharty. 1972. On estimating colloid osmotic pressure in pre-and post-glomerular plasma in the rat. Kidney Int. 2:51–53.PubMedCrossRefGoogle Scholar
  64. 64.
    Kallskog, O., L. O. Lindbom, H. R. Ulfendahl, and M. Wolgast. 1976. Hydrostatic pressures within the vascular structures of the rat kidney. Pfluegers Arch. 363:205–210.CrossRefGoogle Scholar
  65. 65.
    Tonder, K. J. H., and K. Aukland. 1979-1980. Interlobular arterial pressure in the rat kidney. Renal Physiol. 2:214–221.Google Scholar
  66. 66.
    Navar, L. G., P. D. Bell, and T. J. Burke. 1982. Role of macula densa feedback mechanism as a mediator of renal autoregulation. Kidney Int. 22:S157–S164.Google Scholar
  67. 67.
    Casellas, D., and L. G. Navar. 1984. In vitro perfusion of jux-tamedullary nephrons in rats. Am. J. Physiol. 246:F349–F358.PubMedGoogle Scholar
  68. 68.
    Brenner, B. M., J. L. Troy, and T. M. Daugharty. 1971. The dynamics of glomerular ultrafiltration in the rat. J. Clin. Invest. 50:1776–1780.PubMedCrossRefGoogle Scholar
  69. 69.
    Falchuk, K. H., and R. W. Berliner. 1971. Hydrostatic pressures in peritubular capillaries and tubules in the rat kidney. Am. J. Physiol. 220:1422–1426.PubMedGoogle Scholar
  70. 70.
    Allison, M. E., E. M. Lipham, and C. W. Gottschalk. 1972. Hydrostatic pressure in the rat kidney. Am. J. Physiol. 223:975–983.PubMedGoogle Scholar
  71. 71.
    Knox, F. G., L. R. Willis, J. W. Strandhoy, and E. G. Schneider. 1972. Hydrostatic pressures in proximal tubules and peritubule capillaries in the dog. Kidney Int. 2:11–16.PubMedCrossRefGoogle Scholar
  72. 72.
    Navar, L. G., B. Chomdej, and P. D. Bell. 1975. Absence of estimated glomerular capillary pressure autoregulation during interrupted distal delivery. Am. J. Physiol. 229:1596–1603.PubMedGoogle Scholar
  73. 73.
    Navar, L. G., P. D. Bell, and T. J. Burke. 1977. Autoregulatory responses of superficial nephrons, and their association with sodium excretion during arterial pressure alterations in the dog. Circ. Res. 41:487–496.PubMedGoogle Scholar
  74. 74.
    Baer, P. G., and L. G. Navar. 1973. Renal vasodilation and uncoupling of blood flow and filtration rate autoregulation. Kidnex Int. 4:12–21.CrossRefGoogle Scholar
  75. 75.
    Lowenstein, J., E. R. Beranbaum, H. Chasis, and D. S. Baldwin. 1970. Intrarenal pressure and exaggerated natriuresis in essential hypertension. Clin. Sci. 38:359–374.PubMedGoogle Scholar
  76. 76.
    Willassen, Y., and J. Ofstad. 1980. Renal sodium excretion and the peritubular capillary physical factors in essential hypertension. Hypertension 2:771–779.PubMedGoogle Scholar
  77. 77.
    Blantz, R. C., F. C. Rector, and D. W. Seldin. 1974. Effect of hyperoncotic albumin expansion upon glomerular ultrafiltration in the rat. Kidney Int. 6:209–221.PubMedCrossRefGoogle Scholar
  78. 78.
    Blantz, R. C. 1977. Dynamics of glomerular ultrafiltration in the rat. Fed. Proc. 36:2602–2608.PubMedGoogle Scholar
  79. 79.
    Ichikawa, I., D. A. Maddox, M. G. Cogan, and B. M. Brenner. 1978. Dynamics of glomerular ultrafiltration in euvolemic Munich-Wistar rats. Renal Physiol. 1:121–131.Google Scholar
  80. 80.
    Arendshorst, W. J., and C. W. Gottschalk. 1980. Glomerular ultrafiltration dynamics: Euvolemic and plasma volume expanded rats. Am. J. Physiol. 239:F171–F186.PubMedGoogle Scholar
  81. 81.
    Kallskog, O., L. O. Lindbom, H. R. Ulfendahl, and M. Wolgast. 1975. Kinetics of the glomerular ultrafiltration in the rat kidney: An experimental study. Acta Physiol. Scand. 95:293–300PubMedCrossRefGoogle Scholar
  82. 82.
    Aukland, K., K. Heyeraas-Tonder, and G. Naess. 1977. Capillary pressure in deep and superficial glomeruli of the rat kidney. Acta Physiol. Scand. 101:418–427.PubMedCrossRefGoogle Scholar
  83. 83.
    Heller, J., and V. Horacek. 1980. Comparison of directly measured and calculated glomerular capillary pressure in the dog kidney at varying perfusion pressure. Pfluegers Arch. 385:253–258.CrossRefGoogle Scholar
  84. 84.
    Marchand, G. R. 1981. Direct measurement of glomerular capillary pressure in dogs. Proc. Soc. Exp. Biol. Med. 167:428–433.PubMedGoogle Scholar
  85. 85.
    Gertz, K. H., M. Brandis, G. Braun-Schubert, and J. W. Boylan. 1969. The effect of saline infusion and hemorrhage on glomerular filtration pressure and single nephron filtration rate. Pfluegers Arch. 310:193–205.CrossRefGoogle Scholar
  86. 86.
    Andreucci, V. E., J. Herrera-Acosta, F. C. Rector, Jr., and D. W. Seldin. 1971. Effective glomerular filtration pressure and single nephron filtration rate during hydropenia, elevated ureteral pressure, and acute volume expansion with isotonic saline. J. Clin. Invest. 80:2230–2234.CrossRefGoogle Scholar
  87. 87.
    Blantz, R. 1974. Effect of mannitol on glomerular ultrafiltration in the hydropenic rat. J. Clin. Invest. 54:1135–1143.PubMedCrossRefGoogle Scholar
  88. 88.
    Ott, C. E., G. R. Marchand, J. A. Diaz-Buxo, and F. G. Knox. 1976. Determinants of glomerular filtration rate in the dog. Am. J. Physiol. 231:235–239.PubMedGoogle Scholar
  89. 89.
    Hermansson, K., M. Larson, O. Kallskog, and M. Wolgast. 1981. Influence of renal nerve activity on arteriolar resistance, ultrafiltration dynamics and fluid reabsorption. Pfluegers Arch. 389:85–90.CrossRefGoogle Scholar
  90. 90.
    Briggs, J. P., and F. S. Wright. 1979. Feedback control of glomerular filtration rate: Site of the effector mechanism. Am. J. Physiol. 236:F40–F47.PubMedGoogle Scholar
  91. 91.
    Oken, D. E., S. R. Thomas, and D. Mikulecky. 1981. A network thermodynamic model of glomerular dynamics: Application in the rat. Kidney Int. 19:359–373.PubMedCrossRefGoogle Scholar
  92. 92.
    Ichikawa, I. 1982. Evidence for altered glomerular hemodynamics during acute nephron obstruction. Am. J. Phxsiol. 242:F580–F585.Google Scholar
  93. 93.
    Andreucci, V. E., A. Dal Canton, A. Corradi, R. Stanziale, and L. Migone. 1976. Role of the efferent arteriole in glomerular hemodynamics of superficial nephrons. Kidney Int. 9:475–480.PubMedCrossRefGoogle Scholar
  94. 94.
    Navar, L. G., P. D. Bell, R. W. White, R. L. Watts, and R. H. Williams. 1977. Evaluation of the single nephron glomerular filtration coefficient in the dog. Kidney Int. 12:137–149.PubMedCrossRefGoogle Scholar
  95. 95.
    Bell, P. D., and L. G. Navar. 1979. Stop flow pressure feedback responses during reduced renal vascular resistance in the dog. Am. J. Physiol. 237:F204–F209.PubMedGoogle Scholar
  96. 96.
    Deen, W. M., C. R. Robertson, and B. M. Brenner. 1972. A model of glomerular ultrafiltration in the rat. Am. J. Physiol. 223:1178–1183.PubMedGoogle Scholar
  97. 97.
    Brenner, B. M., J. L. Troy, T. M. Daugharty, W. M. Deen, and C.R. Robertson. 1972. Dynamics of glomerular ultrafiltration in the rat. II. Plasma-flow dependence of GFR. Am. J. Physiol. 223:1184–1190.PubMedGoogle Scholar
  98. 98.
    Thomas, C. E., C. E. Ott, P. D. Bell, F. G. Knox, and L. G. Navar. 1983. Glomerular filtration dynamics during vasodilation with acetylcholine in the dog. Am. J. Physiol. 244:F606–F611.PubMedGoogle Scholar
  99. 99.
    Oken, D.E. 1982. An analysis of glomerular dynamics in rat, dog and man. Kidney Int. 22:136–145.PubMedCrossRefGoogle Scholar
  100. 100.
    Huss, R. E., D. J. Marsh, and R. E. Kalaba. 1975. Two models of glomerular filtration rate and renal blood flow in the rat. Ann. Biomed. Eng. 3:72–99.PubMedCrossRefGoogle Scholar
  101. 101.
    Papenfuss, H. D., and J. F. Gross. 1978. Analytic study of the influence of capillary pressure drop and permeability on glomerular ultrafiltration. Microvasc. Res. 16:59–72.PubMedCrossRefGoogle Scholar
  102. 102.
    Lambert, P. P., B. Aeikens, A. Bohle, F. Hanus, S. Pegoff, and M. Vandamme. 1982. A network model of glomerular function. Microvasc. Res. 23:99–128.PubMedCrossRefGoogle Scholar
  103. 103.
    Williams, R. H., C. E. Thomas, L. G. Navar, and A. P. Evan. 1981. Hemodynamic and single nephron function during the maintenance phase of ischemic acute renal failure in the dog. Kidney Int. 19:503–515.PubMedCrossRefGoogle Scholar
  104. 104.
    Andrews, P. M., and A. K. Coffey. 1983. Cytoplasmic contractile elements in glomerular cells. Fed. Proc. 42:3046–3052.PubMedGoogle Scholar
  105. 105.
    Lambert, P. P., A. Verniory, J. P. Gassee, and P. Ficheroulle. 1972. Sieving equations and effective glomerular filtration pressure. Kidney Int. 2:131–146.PubMedCrossRefGoogle Scholar
  106. 106.
    Chang, R. L. S., C. R. Robertson, W. M. Deen, and B. M. Brenner. 1975. Permselectivity of the glomerular capillary wall to macromolecules. I. Theoretical considerations. Biophys. J. 15:861–886.PubMedCrossRefGoogle Scholar
  107. 107.
    DuBois, R., P. Decoodt, J. P. Gassee, A. Verniory, and P. P. Lambert. 1975. Determination of glomerular intracapillary and transcapillary pressure gradients from sieving data. I. A mathematical model. Pfluegers Arch. 356:299–316.CrossRefGoogle Scholar
  108. 108.
    Kedem, O., and A. Katchalsky. 1958. Thermodynamic analysis of the permeability of biological membranes to non-electrolytes. Biochem. Biophys. Acta 27:229–246.PubMedCrossRefGoogle Scholar
  109. 109.
    Bresler, E. H., and L. S. Groome. 1982. On equations for combined convective and diffusive transport of neutral solute across porous membranes. Am. J. Physiol. 241:F469–F476.Google Scholar
  110. 110.
    Taylor, A. E., and D. N. Granger. 1984. Exchange of macromolecules across the microcirculation. In: Handbook of Physiology: Cardiovascular system microcirculation, Voume 4. I. E. Renkin and C. C. Michelf, eds. American Physiological Society, Bethesda, Md. pp. 467–520.Google Scholar
  111. 111.
    Whiteside, C., and M. Silverman. 1983. Determination of glomerular permselectivity to neutral dextrans in the dog. Am. J. Physiol. 245:F485–F495.PubMedGoogle Scholar
  112. 112.
    Lambert, P. P., R. DuBois, P. Decoodt, J. P. Gassee, and A. Verniory. 1975. Determination of glomerular intracapillary and transcapillary pressure gradients from sieving data. II. A physiological study in the normal dog. Pfluegers Arch. 359:1–22.CrossRefGoogle Scholar
  113. 113.
    Vanrenterghem, Y., R. Vanholder, M. Lammens-Verslijpe, and P. P. Lambert. 1980. Sieving studies in urea-induced nephropathy in the dog. Clin. Sci. 58:65–75.PubMedGoogle Scholar
  114. 114.
    Chang, R. L. S., W. M. Deen, C. R. Robertson, and B. M. Brenner. 1975. Permselectivity of the glomerular capillary wall. III. Restricted transport of polyanions. Kidney Int. 8:212–218.PubMedCrossRefGoogle Scholar
  115. 115.
    Bohrer, M. P., C. Baylis, H. D. Humes, R. J. Glassock, C. R. Robertson, and B. M. Brenner. 1978. Permselectivity of the glomerular capillary wall: Facilitated transport of circulating poly-cations. J. Clin. Invest. 61:72–78.PubMedCrossRefGoogle Scholar
  116. 116.
    Rennke, H. G., Y. Patel, and M. Venkatachalam. 1978. Glomerular filtration of proteins: Clearance of anionic, neutral, and cationic horseradish peroxidase in the rat. Kidney Int. 13:324–328.CrossRefGoogle Scholar
  117. 117.
    Bohrer, M. P., W. M. Deen, C. R. Robertson, J. L. Troy, and B. M. Brenner. 1979. Influence of molecular configuration on the passage of macromolecules across the glomerular capillary wall. J. Gen. Physiol. 74:583–593.PubMedCrossRefGoogle Scholar
  118. 118.
    Rennke, H. G., and M. A. Venkatachalam. 1979. Glomerular permeability of macromolecules: Effect of molecular configuration on the fractional clearance of uncharged dextran and neutral horseradish peroxidase in the rat. J. Clin. Invest. 63:713–717.PubMedCrossRefGoogle Scholar
  119. 119.
    Verniory, A., R. DuBois, P. Decoodt, J. P. Gassee, and P. P. Lambert. 1973. Measurement of the permeability of biological membranes: Application to the glomerular wall. J. Gen. Physiol. 62:489–507.PubMedCrossRefGoogle Scholar
  120. 120.
    Jorgensen, K. E., and J. V. Moller. 1979. Use of flexible polymers as probes of glomerular pore size. Am. J. Physiol. 236:F103–F111.PubMedGoogle Scholar
  121. 121.
    Lambert, P. P., J. P. Gassee, A. Verniory, and P. Ficheroulle. 1971. Measurement of the glomerular filtration pressure from sieving data for macromolecules. Pfluegers Arch. 329:34–58.CrossRefGoogle Scholar
  122. 122.
    Bridges, C. R., B. D. Myers, B. M. Brenner, and W. M. Deen. 1982. Glomerular charge alterations in human minimal change nephropathy. Kidney Int. 22:677–684.PubMedCrossRefGoogle Scholar
  123. 123.
    White, R. J., and L. G. Navar. 1975. Modeling of renal hemodynamics in the dog: Glomerular and peritubular capillary dynamics. Summer Computer Simulation Conf. 2:878–888.Google Scholar
  124. 124.
    Marshall, E. A., and E. A. Trowbridge. 1974. A mathematical model of the ultrafiltration process in a single glomerular capillary. Theor. Biol. 48:389–412.CrossRefGoogle Scholar
  125. 125.
    Steven, K., and S. Strobaek. 1974. Renal corpuscular hydro-dynamic: digital computer simulation. Pfluegers Arch. 348:317–331.CrossRefGoogle Scholar
  126. 126.
    Kallskog, O., L. O. Lindbom, H. R. Ulfendahl, and M. Wolgast. 1975. Kinetics of the glomerular ultrafiltration in the rat kidney: A theoretical study. Acta Physiol. Scand. 95:191–200.PubMedCrossRefGoogle Scholar
  127. 127.
    Knox, F. G., J. L. Cuche, C. E. Ott, J. A. Diaz-Buxo, and G. Marchand. 1975. Regulation of glomerular filtration and proximal tubule reabsorption. Cire. Res. 36:107–118.Google Scholar
  128. 128.
    Earley, L. E., and R. W. Schrier. 1973. Intrarenal control of sodium excretion by hemodynamic and physical factors. In: Handbook of Physiology, Section 8. J. Orloff and R. W. Berliner, eds. American Physiological Society, Bethesda, Md. pp. 721–762.Google Scholar
  129. 129.
    Dworkin, L. D., I. Ichikawa, and B. M. Brenner. 1983. Hormonal modulation of glomerular function. Am. J. Physiol. 244:F95–F104.PubMedGoogle Scholar
  130. 130.
    Scharschmidt, L. A., E. Lianos, and M.J. Dunn. 1983. Arachido-nate metabolites and the control of glomerular function. Fed. Proc. 42:3058–3063.PubMedGoogle Scholar
  131. 131.
    Blantz, R. C., K. S. Konner, and B. J. Tucker. 1976. Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat. J. Clin. Invest. 57:419–434.PubMedCrossRefGoogle Scholar
  132. 132.
    Baylis, C., W. M. Deen, B. D. Myers, and B. M. Brenner. 1976. Effects of some vasodilator drugs on transcapillary fluid exchange in renal cortex. Am. J. Physiol. 230:1148–1158.PubMedGoogle Scholar
  133. 133.
    Schor, N., I. Ichikawa, and B. M. Brenner. 1981. Mechanisms of action of various hormones and vasoactive substances on glomerular ultrafiltration in the rat. Kidney Int. 20:442–451.PubMedCrossRefGoogle Scholar
  134. 134.
    Thomas, C. E., P. D. Bell, and L. G. Navar. 1982. Influence of bradykinin and papaverine on renal and glomerular hemodynamics in dogs. Renal Physiol. 5:197–205.PubMedGoogle Scholar
  135. 135.
    Rosivall, L., P. K. Carmines, and L. G. Navar. 1984. Effects of renal arterial angiotensin I infusions on glomerular dynamics in sodium replete dogs. Kidney Int. 26:263–268.PubMedCrossRefGoogle Scholar
  136. 136.
    Baylis, C., I. Ichikawa, W. T. Willis, C. B. Wilson, and B. M. Brenner. 1977. Dynamics of glomerular ultrafiltration. IX. Effects of plasma protein concentration. Am. J. Physiol. 232:F58–F71.PubMedGoogle Scholar
  137. 137.
    Schor, N., I. Ichikawa, and B. M. Brenner. 1980. Glomerular adaptations to chronic dietary salt restriction or excess. Am. J. Physiol. 238:F428–F436.PubMedGoogle Scholar
  138. 138.
    Navar, L. G., D. Jirakulsomchok, P. D. Bell, C. E. Thomas, and W. C. Huang. 1982. Influence of converting enzyme inhibition on renal hemodynamics and glomerular dynamics in sodium restricted dogs. Hypertension 4:58–68.PubMedGoogle Scholar
  139. 139.
    Myers, B. D., W. M. Deen, and B. M. Brenner. 1975. Effects of norepinephrine and angiotensin II on the determinants of glomerular ultrafiltration and proximal tubule fluid reabsorption in the rat. Circ. Res. 37:101–110.PubMedGoogle Scholar
  140. 140.
    Selkurt, E. E., P. W. Hall, and M. P. Spencer. 1949. Influence of graded arterial pressure decrement on renal clearance of creatinine, p-amino hippurate and sodium. Am. J. Physiol. 159:369–378.PubMedGoogle Scholar
  141. 141.
    Shipley, R. E., and R. S. Study. 1951. Changes in renal blood flow, extraction of inulin, GFR, tissue pressure and urine flow with acute alterations of renal artery blood pressure. Am. J. Physiol. 167:676–688.PubMedGoogle Scholar
  142. 142.
    Guyton, A. C., J. B. Langston, and G. Navar. 1964. Theory for renal autoregulation by feedback at the juxtaglomerular apparatus. Circ. Res. 15:187–196.PubMedGoogle Scholar
  143. 143.
    Thurau, K. 1966. Nature of autoregulation of renal blood flow. Proc. 3rd Int. Congr. Nephrol. 1:162–173.Google Scholar
  144. 144.
    Navar, L. G. 1978. Renal autoregulation: Perspectives from whole kidney and single nephron studies. Am. J. Physiol. 234:F357–F370.PubMedGoogle Scholar
  145. 145.
    Robertson, C. R., W. M. Deen, J. L. Troy, and B. M. Brenner. 1971. Dynamics of glomerular ultrafiltration in the rat. III. Hemodynamics and autoregulation. Am. J. Physiol. 223:1191–1200.Google Scholar
  146. 146.
    Navar, L. G., D. J. Marsh, R. C. Blantz, J. Hall, D. W. Ploth, and A. Nasjletti. 1982. Intrinsic control of renal hemodynamics. (Symposium Report). Fed. Proc. 41:3022–3030.PubMedGoogle Scholar
  147. 147.
    Bell, P. D., and L. G. Navar. 1982. Macula densa feedback control of glomerular filtration: Role of cytosolic calcium. Miner. Electrolyte Metab. 8:61–77.PubMedGoogle Scholar
  148. 148.
    Adams, P. L., F. F. Adams, P. D. Bell, and L. G. Navar. 1980. Impaired renal blood flow autoregulation in ischemic acute renal failure. Kidney Int. 18:68–76.PubMedCrossRefGoogle Scholar
  149. 149.
    Tucker, B. J., R. W. Steiner, L. C. Gushwa, and R. C. Blantz. 1978. Studies on the tubulo-glomerular feedback system in the rat: The mechanism of reduction in filtration rate with benzolamide. J. Clin. Invest. 62:993–1004.PubMedCrossRefGoogle Scholar
  150. 150.
    Luke, R. G., and J. H. Galla. 1983. Chloride-depletion alkalosis with a normal extracellular fluid volume. Am. J. Physiol. 245:F419–F424.PubMedGoogle Scholar
  151. 151.
    Schnermann, J., F. S. Wright, J. M. Davis, W. V. Stackelberg, and G. Grill. 1970. Regulation of superficial nephron filtration rate by tubulo-glomerular feedback. Pfluegers Arch. 318:147–175.CrossRefGoogle Scholar
  152. 152.
    Schnermann, J., A. E. G. Persson, and B. Agerup. 1973. Tu-buloglomerular feedback: Nonlinear relation between glomerular hydrostatic pressure and loop of Henle perfusion. J. Clin. Invest. 52:862–869.PubMedCrossRefGoogle Scholar
  153. 153.
    Burke, T. J., L. G. Navar, J. R. Clapp, and R. R. Robinson. 1974. Response of single nephron glomerular filtration rate to distal nephron microperfusion. Kidney Int. 6:230–240.PubMedCrossRefGoogle Scholar
  154. 154.
    Bell, P. D., C. Thomas, R. H. Williams, and L. G. Navar. 1978. Filtration rate and stop-flow pressure feedback responses to nephron perfusion in the dog. Am. J. Physiol. 234:F154–F165.PubMedGoogle Scholar
  155. 155.
    Persson, B. E., and A. E. G. Persson. 1981. The existence of a tubulo-glomerular feedback mechanism in the amphiuma nephron. Pfluegers Arch. 391:129–134.CrossRefGoogle Scholar
  156. 156.
    Muller-Suur, R., H. R. Ulfendahl, and A. E. G. Persson. 1983. Evidence for tubuloglomerular feedback in juxtamedullary nephrons of young rats. Am. J. Physiol. 244:F425–F431.PubMedGoogle Scholar
  157. 157.
    Bell, P. D., L. G. Navar, D. W. Ploth, and C. B. McLean. 1980. Tubulo-glomerular feedback responses during perfusion with non-electrolyte solutions in the rat. Kidney Int. 18:460–471.PubMedCrossRefGoogle Scholar
  158. 158.
    Ichikawa, 1.1982. Direct analysis of the effector mechanism of the tubuloglomerular feedback system. Am. J. Physiol. 243:F447–F455.Google Scholar
  159. 159.
    Blantz, R. C., L. C. Gushwa, and A. E. G. Persson. 1983. Tubuloglomerular feedback (TGF) released response in glomerular capillary hydrostatic pressure (PG) and nephron filtration rate (SNGFR) in hydropenic (H) and in angiotensin (All) and prostaglandin (PG) blocked rats. Am. Soc. Nephrol. 16:149A.Google Scholar
  160. 160.
    Bell, P. D., M. Reddington, D. Ploth, and L. G. Navar. 1984. Tubuloglomerular feedback mediated decreases in glomerular pressure in Munich-Wistar rats. Am. J. Physiol. 247:F877–F880.PubMedGoogle Scholar
  161. 161.
    Navar, L. G., T.J. Burke, R.R. Robinson, and J. R. Clapp. 1974. Distal tubular feedback in the autoregulation of single nephron glomerular filtration rate. J. Clin. Invest. 53:516–525.PubMedCrossRefGoogle Scholar
  162. 162.
    Ploth, D. W., J. Schnermann, H. Dahlheim, M. Hermle, and E. Schmidmeier. 1977. Autoregulation and tubuloglomerular feedback in normotensive and hypertensive rats. Kidney Int. 12:253–267.PubMedCrossRefGoogle Scholar
  163. 163.
    Schnermann, J., J. M. Davis, P. Wunderlich, D. Z. Levine, and M. Horster. 1971. Technical problems in the micropuncture determination of nephron filtration rate and their functional implications. Pfluegers Arch. 329:307–320.CrossRefGoogle Scholar
  164. 164.
    Ploth, D. W., J. Rudolph, R. LaGrange, and L. G. Navar. 1979. Tubulo-glomerular feedback and single nephron function after converting enzyme inhibition in the rat. J. Clin. Invest. 64:1325— 1335.CrossRefGoogle Scholar
  165. 165.
    Williams, R. H., C. Thomas, P. D. Bell, and L. G. Navar. 1977. Autoregulation of nephron filtration rate in the dog assessed by indicator-dilution technique. Am. J. Physiol. 233:F282–F289.PubMedGoogle Scholar
  166. 166.
    Moore, L. C., J. Schnermann, and S, Yarimizu. 1979. Feedback mediation of SNGFR autoregulation in hydropenic and DOCA-salt loaded rats. Am. J. Physiol. 237:F63–F74.PubMedGoogle Scholar
  167. 167.
    Morgan, T., and R. W. Berliner. 1969. A study by continuous microperfusion of water and electrolyte movements in the loop of Henle and distal tubule of the rat. Nephron 6:388–405.PubMedCrossRefGoogle Scholar
  168. 168.
    Schnermann, J., D. W. Ploth, and M. Hermle. 1976. Activation of tubuloglomerular feedback by chloride transport. Pfluegers Arch. 362:229–240.CrossRefGoogle Scholar
  169. 169.
    Bell, P. D., C. B. McLean, and L. G. Navar. 1981. Dissociation of tubuloglomerular feedback responses from distal tubule chloride concentration in the rat. Am. J. Physiol. 240:F111—Fl 19.Google Scholar
  170. 170.
    Bell, P. D., and L. G. Navar. 1982. Relationship between tubuloglomerular feedback responses and perfusate hypotonicity. Kidney Int. 22:234–239.PubMedCrossRefGoogle Scholar
  171. 171.
    Briggs, J., G. Schubert, and J. Schnermann. 1982. Further evidence for an inverse relationship between macula densa NaCl concentration and filtration rate. Pfluegers Arch. 392:372–378.CrossRefGoogle Scholar
  172. 172.
    Briggs, J. P., J. Schnermann, and F. S, Wright. 1980. Failure of tubule fluid osmolality to affect feedback regulation of glomerular filtration. Am. J. Physiol. 239:F427–F432.PubMedGoogle Scholar
  173. 173.
    Bell, P. D. 1982. Luminal and cellular mechanisms for the mediation of tubular-glomerular feedback responses. Kidney Int. 22.S97–S103.Google Scholar
  174. 174.
    Bell, P. D., and L. G. Navar. 1982. Cytoplasmic calcium in the mediation of macula densa tubulo-glomerular feedback responses. Science 215:670–673.PubMedCrossRefGoogle Scholar
  175. 175.
    Bell, P. D., and M. Reddington. 1983. Intracellular calcium in the transmission of tubuloglomerular feedback signals. Am. J. Ph-iol. 245:F295–F302.Google Scholar
  176. 176.
    Shaw, J. O. 1981. Effects of extracellular Ca+ + and the intracellular Ca++ antagonist 8-(N, N, diethyl amino)-octyl 3, 4, 5-trimethoxybenzoate on rabbit platelet conversion of arachidonic acid to thromboxane. Prostaglandins 21:571–579.PubMedCrossRefGoogle Scholar
  177. 177.
    Schnermann, J., H. Osswald, and M. Hermle. 1977. Inhibitory effect of methylxanthines on feedback control of glomerular filtration in the rat kidney. Pfluegers Arch. 369:39–48.CrossRefGoogle Scholar
  178. 178.
    Bell, P. D., and M. Reddington. 1983. Cyclicnucleotide-calcium interaction in the mediation of macula densa tubuloglomerular feedback signals. Fed. Proc. 42:298.Google Scholar
  179. 179.
    Seamon, K. B., and J. W. Daley. 1981. Forskolin: A unique diterpene activator of cyclic AMP-generating systems. J. Cyclic Nucleotide Res. 7:201–224.PubMedGoogle Scholar
  180. 180.
    Kaser-Glanzmann, R., M. Jakabova, J. W. George, and E. F. Luscher. 1977. Stimulation of calcium uptake in platelet mem-brane vesicles by adenosine 3′, 5′-cyclic monophosphate and protein kinase. Biochim. Biophys. Acta 466:429–440.PubMedCrossRefGoogle Scholar
  181. 181.
    Bell, P. D. 1984. Participation of prostaglandins in the mediation of tubuloglomerular feedback responses. Fed. Proc. 43:409.Google Scholar
  182. 182.
    Rosivall, L., D. F. Rinder, J. Champion, M. C. Khosla, L. G. Navar, and S. Oparil. 1983. Intrarenal angiotensin I conversion at normal and reduced renal blood flow in the dog. Am. J. Physiol. 245:F408–F415.PubMedGoogle Scholar
  183. 183.
    Navar, L. G., and L. Rosivall. 1984. Contribution of the renin-angiotensin system to the control of intrarenal hemodynamics. Kidney Int. 25:857–868.PubMedCrossRefGoogle Scholar
  184. 184.
    Celio, M. R., and T. Inagami. 1981. Angiotensin II immunoreac-tivity coexists with renin in the juxtaglomerular granular cells of the kidney. Proc. Natl. Acad. Sci. USA 78:3897–3900.PubMedCrossRefGoogle Scholar
  185. 185.
    Taugner, R., E. Hackenthal, E. Rix, R. Nobling, and K. Poulsen. 1982. Immunocytochemistry of the renin-angiotensin system: Renin, angiotensinogen, angiotensin I, angiotensin II, and converting enzyme in the kidneys of mice, rats, and tree shrews. Kidney Int. 22:S533–S543.Google Scholar
  186. 186.
    Osborne, M. J., B. Droz, P. Meyer, and F. Morel. 1975. Angiotensin II: Renal localization in glomerular mesangial cells by autoradiography. Kidney Int. 8:245–254.PubMedCrossRefGoogle Scholar
  187. 187.
    Ploth, D. W., and L. G. Navar. 1979. Intrarenal effects of the renin-angiotensin system. Fed. Proc. 38:2280–2285.PubMedGoogle Scholar
  188. 188.
    Huang, W. C., D. W. Ploth, P. D. Bell, J. Work, and L. G. Navar. 1981. Bilateral renal function responses to converting enzyme inhibitor (SQ20, 881) in two-kidney, one clip Goldblatt hypertensive rats. Hypertension 3:285–293.PubMedGoogle Scholar
  189. 189.
    Steiner, R. W., B. J. Tucker, and R. C. Blantz. 1979. Glomerular hemodynamics in rats with chronic sodium depletion. J. Clin. Invest. 64:503–512.PubMedCrossRefGoogle Scholar
  190. 190.
    Steiner, R. W., and R. C. Blantz. 1979. Acute reversal by saralasin of multiple intrarenal effects of angiotensin II. Am. J. Physiol. 237:F386–F391.PubMedGoogle Scholar
  191. 191.
    Rosivall, L., and L. G. Navar. 1983, Effects on renal hemodynamics of intra-arterial infusions of angiotensin I and II. Am. J. Physiol. 245:F181–F187.PubMedGoogle Scholar
  192. 192.
    Hall, J. E. 1982. Regulation of renal hemodynamics. Int. Rev. Physiol. 26:243–321.PubMedGoogle Scholar
  193. 193.
    Hall, J. E., A. C. Guyton, T. E. Jackson, T. G. Coleman, T. E. Lohmeier, and N. C. Trippodo. 1977. Control of glomerular filtration rate by renin-angiotensin system. Am. J. Physiol. 233:F366–F372.PubMedGoogle Scholar
  194. 194.
    Murray, R. B., and R. L. Malvin. 1979. Intrarenal renin and autoregulation of renal plasma flow and glomerular filtration rate. Am. J. Physiol. 236:F559–F566.PubMedGoogle Scholar
  195. 195.
    Hall, J. E., A. C. Guyton, and A. W. Cowley, Jr. 1977. Dissociation of renal blood flow and filtration rate autoregulation by renin depletion, Am. J. Physiol. 232:F215–F221.PubMedGoogle Scholar
  196. 196.
    Nasjletti, A., and K. U. Malik. 1981. Interrelationships among prostaglandins and vasoactive substances. Med, Clin. North Am. 65:881–889.Google Scholar
  197. 197.
    Gerber, J. G., R. D. Olson, and A. S, Nies, 1981. Interrelationship between prostaglandins and renin release. Kidney Int. 19:816–821.PubMedCrossRefGoogle Scholar
  198. 198.
    Baer, P. G., and J. C. McGiff. 1980. Hormonal systems and renal hemodynamics. Annu. Rev. Physiol. 42:582–601.CrossRefGoogle Scholar
  199. 199.
    Baer, P. G. 1981. Contribution of prostaglandins to renal blood flow maintenance is determined by the level of activity of the renin-angiotensin system. Life Sci. 28:587–593.PubMedCrossRefGoogle Scholar
  200. 200.
    Blasingham, M. C., and A. Nasjletti. 1980. Differential renal effects of cyclooxygenase inhibition in sodium-replete and sodium-deprived dog. Am. J. Physiol. 239:F360–F365.PubMedGoogle Scholar
  201. 201.
    Carmines, P. K., L. Rosivall, M. F. Till, and L. G. Navar. 1983. Renal hemodynamic effects of Captopril in anesthetized sodium-restricted dogs: Relative contributions of prostaglandin stimulation and suppressed angiotensin activity. Renal Physiol. 6:281–287.PubMedGoogle Scholar
  202. 202.
    Thurau, K., J. Schnermann, W. Nagel, M, Horster, and M. Wahl. 1967. Composition of tubular fluid in the macula densa segment as a factor regulating the function of the juxtaglomerular apparatus. Circ. Res. 20-21(II):79–81.Google Scholar
  203. 203.
    Kishimoti, T., M. Maekawa, M. Miyazaki, K. Yamamoto, and J. Ueda. 1972. Effects of renal venous pressure elevations on renal hemodynamics, urine formation and renin release. Jpn. Cire. J. 36:439–449.CrossRefGoogle Scholar
  204. 204.
    Churchill, P. C., M. C. Churchill, and F. D. McDonald. 1978. Renin secretion and distal tubule Na+ in rats. Am. J. Physiol. 235:F611–F616.PubMedGoogle Scholar
  205. 205.
    Hofbauer, K. G., A. Konrads, K. Schwarz, and U. Werner. 1978. Role of cyclic AMP in the regulation of renin release from the isolated perfused kidney. Klin. Wochenschr. 56:51–59.PubMedCrossRefGoogle Scholar
  206. 206.
    Park, C. S., D. S. Han, and J. C. S. Fray. 1981. Calcium in the control of renin secretion: Ca2 + influx as an inhibitory signal. Am. J. Physiol. 240:F70–F74.PubMedGoogle Scholar
  207. 207.
    Fray, J. C. S. 1980. Stimulus-secretion coupling of renin: Role of hemodynamic and other factors. Circ. Res. 47:485–492.PubMedGoogle Scholar
  208. 208.
    Baumbach, L., and P. P. Leyssac. 1977. Studies on the mechanism of renin release from isolated superfused rat glomeruli: Effects of calcium, calcium ionophore and lanthanum. J. Physiol. (London) 273:745–764.Google Scholar
  209. 209.
    Muller-Suur, R., H. U. Gutsche, and H. J. Schurek. 1976. Acute and reversible inhibition of tubulo-glomerular feedback mediated afferent vasoconstriction by the calcium-antagonist verapamil. Curr. Probl. Clin. Biochem. 6:291–298.PubMedGoogle Scholar
  210. 210.
    Stowe, N., J. Schnermann, and M. Hermle. 1979. Feedback regulation of nephron filtration rate during pharmacologic interference with the renin angiotensin and adrenergic systems in rats. Kidney Int. 15:473–486.PubMedCrossRefGoogle Scholar
  211. 211.
    Muller-Suur, R., H. U. Gutsche, K. F. Samwer, W. Oelkers, and K. Hierholzer. 1975. Tubuloglomerular feedback in rat kidneys of different renin contents. Pfluegers Arch. 359:33–56.CrossRefGoogle Scholar
  212. 212.
    Moore, L. C., S. Yarimizu, G. Schubert, P. C. Weber, and J. Schnermann. 1980. Dynamics of tubuloglomerular feedback adaptation to acute and chronic changes in body fluid volume. Pfluegers Arch. 387:39–45.CrossRefGoogle Scholar
  213. 213.
    Ploth, D. W., and R. N. Roy. 1982. Renin angiotensin influence on tubuloglomerular activity in the rat. Kidney Int. 22:S114–S121.Google Scholar
  214. 214.
    Kiil, F., J. Kjekshus, and E. Loyning. 1969. Renal autoregulation during infusion of noradrenaline, angiotensin, and acetylcholine. Acta Physiol. Scand. 76:10–23.PubMedCrossRefGoogle Scholar
  215. 215.
    Katz, M. A., and L. Shear. 1975. Effects of renal nerves on renal hemodynamics. I. Direct stimulation and carotid occlusion. Nephron 14:246–256.PubMedCrossRefGoogle Scholar
  216. 216.
    Johns, E. J. 1980. A comparison of the ability of two angiotensin II receptor blocking drugs, l-Sar-8-Ala angiotensin II and l-Sar-8-Ile angiotensin II, to modify the regulation of glomerular filtration rate in the cat. Br. J. Pharmacol. 71:499–506.PubMedGoogle Scholar
  217. 217.
    Kon, V., and I. Ichikawa. 1983. Effector loci for renal nerve control of cortical microcirculation. Am. J. Physiol. 245:F545–553.Google Scholar
  218. 218.
    Nomura, G., Y. Kibe, S. Arai, D. Uno, and J. Takeuchi. 1976. Distribution of intrarenal blood flow after renal denervation in the dog. Nephron 16:126–133.PubMedCrossRefGoogle Scholar
  219. 219.
    Pelayo, J. C., M.G. Ziegler, A. J. Pedro, and R. C. Blantz. 1983. Renal denervation in the rat: Analysis of glomerular and tubular function. Am. J. Physiol. 244:F70–F77.PubMedGoogle Scholar
  220. 220.
    Takabatake, T. 1982. Feedback regulation of glomerular filtration rate in the denervated kidney. Kidney Int. 22(Suppl. 12):S129–S135.Google Scholar
  221. 221.
    Aukland, K. 1968. Effect of adrenaline, nonadrenaline, angiotensin and renal nerve stimulation on intrarenal distribution of blood flow in dogs. Acta Physiol. Scand. 72:498–509.PubMedCrossRefGoogle Scholar
  222. 222.
    Barclay, J., W. T. Cooke, and R. A. Kenney. 1947. Observations on the effects of adrenalin on renal function and circulation in man. Am. J. Physiol. 151:621–625.PubMedGoogle Scholar
  223. 223.
    Click, R. L., W. L. Joyner, and J. P. Gilmore. 1979. Reactivity of glomerular afferent and efferent arterioles in renal hypertension. Kidney Int. 15:109–115.PubMedCrossRefGoogle Scholar
  224. 224.
    Edwards, R. M. 1982. Response of isolated micro vessels to intraluminal pressure, nonrepinephrine, and angiotensin II. Am. Soc. Nephrol. 15:150A.Google Scholar
  225. 225.
    de Rouffignac, C., S. Deiss, and J. P. Bonvalet. 1970. Détermination du taux individual de filtration glomiralaire des nephrons accessibles et inaccessibles a la microponction. Pfluegers Arch. 315:273–290.CrossRefGoogle Scholar
  226. 226.
    Baines, A. D. 1973. Redistribution of nephron function in response to chronic and acute solute loads. Am. J. Physiol. 224:237–244.PubMedGoogle Scholar
  227. 227.
    Bonvalet, J. P., P. Bencsáth, and C. de Rouffignac. 1972. Glomerular filtration rate of superficial and deep nephrons during aortic constriction. Am. J. Physiol. 222:599–606.PubMedGoogle Scholar
  228. 228.
    Bruno, F. J., E. A. Alexander, A. L. Riley, and N. G. Levinsky. 1974. Superficial and juxtamedullary nephron function during saline loading in the dog. J. Clin. Invest. 53:971–979.CrossRefGoogle Scholar
  229. 229.
    Horster, M., and K. Thurau. 1968. Micropuncutre studies on the filtration rate of single superficial and juxtamedullary glomeruli in the rat kidney. Pfluegers Arch. 301:162–181.CrossRefGoogle Scholar
  230. 230.
    Coelho, J. B. 1974. Sodium metabolism and intrarenal distribution of nephron glomerular filtration rates in the unanesthetized rat. Proc. Soc. Exp. Biol. Med. 146:225–231.PubMedGoogle Scholar
  231. 231.
    Chalbardes, D., P. Doujiol, S. Diess, J. P. Bonvalet, and C. de Rouffignac. 1974. Intrarenal glomerular filtration rate distribution in salt-loaded rats. Pfluegers Arch. 349:191–202.CrossRefGoogle Scholar
  232. 232.
    Davis, J. M., H. Brechtelsbauer, P. Prucksunand, J. Weigl, J. Schnermann, and K. Kramer. 1974. Relationship between salt loading and distribution of nephron filtration rates in the dog. Pfluegers Arch. 350:259–272.CrossRefGoogle Scholar
  233. 233.
    Barratt, J. L., J. D. Wallin, F. C. Rector, and D. W. Seldin. 1973. Influence of volume expansion on single nephron filtration rate and plasma flow in the rat. Am. J. Physiol. 224:643–650.PubMedGoogle Scholar
  234. 234.
    Mandin, H., A. H. Israelit, F. C. Rector, Jr., and D. W. Seldin. 1971. Effect of saline infusions on intrarenal distribution of glomerular filtrate and proximal reabsorption in the dog. J. Clin. Invest. 50:514–522.PubMedCrossRefGoogle Scholar
  235. 235.
    Poujeol, P., D. Chabardés, J. P. Bonvalet, and C. de Rouffignac. 1975. Glomerular filtration rate and microsphere distributions in single nephron of rat kidney. Pfluegers Arch. 357:291–301.CrossRefGoogle Scholar
  236. 236.
    Bonvalet, J. P., and C. de Rouffignac. 1981. Distribution of ferro-cyanide along the proximal tubular lumen of the rat kidney: Its implications upon hydrodynamics. J. Physiol. (London) 318:85–98.Google Scholar
  237. 237.
    Cohen, H. J., D. J. Marsh, and B. Kayser. 1983. Autoregulation in vasa recta of the rat kidney. Am. J. Physiol. 245:F32–F40.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • L. Gabriel Navar
    • 1
  • P. Darwin Bell
    • 1
  • Andrew P. Evan
    • 2
  1. 1.Nephrology Research and Training Center and Department of Physiology and BiophysicsUniversity of Alabama School of MedicineBirminghamUSA
  2. 2.Department of AnatomyIndiana University Medical CenterIndianapolisUSA

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