Regulation of Pulsatile Luteinizing Hormone Release During the Estrous Cycle and Pregnancy in the Rat

  • R. V. Gallo
  • G. N. Babu
  • A. Bona-Gallo
  • E. Devorshak-Harvey
  • R. E. Leipheimer
  • J. Marco
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 219)

Abstract

Luteinizing hormone (LH) secretion during the rat estrous cycle (Gallo, 1981; Higuchi and Kawakami, 1982; Fox and Smith, 1985) and pregnancy (Gallo et al., 1985) occurs in a pulsatile manner. Moreover, changes in the amplitude and frequency characteristics of this secretion take place with different stages of the 4-day estrous cycle and during different stages of gestation in this species. Plasma levels of estradiol (E2) and progesterone (P) also vary from stage to stage in the estrous cycle (Butcher et al., 1974; Kalra and Kalra, 1974b; Smith et al., 1975; Nequin et al., 1979) as well as during the different stages of pregnancy in the rat (Morishige et al., 1973; Taya and Greenwald, 1981; Bridges, 1984). The emphasis in our work is to study the neuroendocrine regulation of pulsatile LH secretion in a physiological context. Therefore, the aim of our experiments has been to first describe the normal changes that occur in LH pulse amplitude and frequency throughout the estrous cycle and pregnancy, and then to define the regulatory negative feedback roles of E2 and/or P during each 24-h interval of the rat estrous cycle, and during specific stages of gestation.

Keywords

Estrogen Nicotine Testosterone Progesterone Catecholamine 

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References

  1. Adler BA, Crowley WR, 1984. Modulation of luteinizing hormone release and catecholamine activity by opiates in the female rat. Neuroendocrinology 38:248–53PubMedCrossRefGoogle Scholar
  2. Advis JP, McCann SM, Negro-Vilar A, 1980. Evidence that catecholaminergic and peptidergic (luteinizing hormone-releasing hormone) neurons in suprachiasmatic-medial preoptic, medial basal hypothalamus and median eminence are involved in estrogen negative feedback. Endocrinology 107:892–901PubMedCrossRefGoogle Scholar
  3. Akaka J, O’Laughlin-Phillips E, Antczak E, Rothchild I, 1977. The relationship between the age of the corpus luteum (CL) and the luteolytic effect of an LH antiserum: comparison of hysterectomized pseudopregnant rats with intact pregnant rats for their response to LHAS treatment at four stages of CL activity. Endocrinology 100:1334–40PubMedCrossRefGoogle Scholar
  4. Akema T, Tadokoro Y, Kawakami M, 1983. Changes in the characteristics of pulsatile LH secretion after estradiol implantation into the preoptic area and the basal hypothalamus in ovariectomized rats. Endocrinol Jpn 30:281–87PubMedCrossRefGoogle Scholar
  5. Akema T, Tadokoro Y, Kimura F, 1984. Regional specificity in the effect of estrogen implantation within the forebrain on the frequency of pulsatile luteinizing hormone secretion in the ovariectomized rat. Neuroendocrinology 39:517–23PubMedCrossRefGoogle Scholar
  6. Babu GN, Bona-Gallo A, Gallo RV, 1986. Interaction between estradiol and a nonsteroidal factor in porcine follicular fluid in regulating LH pulse amplitude between the mornings of diestrus 2 and proestrus in the rat. Neuroendocrinology 44:8–14PubMedCrossRefGoogle Scholar
  7. Babu GN, Marco J, Bona-Gallo A, Gallo RV, 1987. Steroid-independent endogenous opioid peptide suppression of pulsatile LH release between estrus and diestrus 1 in the rat estrous cycle. Brain Res (in press)Google Scholar
  8. Barkan A, Regiani S, Duncan J, Papavasiliou S, Marshall JC, 1984. Opioids modulate pituitary receptors for gonadotropin-releasing hormone. Endocrinology 112:387–89CrossRefGoogle Scholar
  9. Ben-Jonathan N, Neill MA, Arbogast LA, Peters LL, Hoefer MT, 1980. Dopamine in hypophysial portal blood: relationship to circulating prolactin in pregnant and lactating rats. Endocrinology 106:690–96PubMedCrossRefGoogle Scholar
  10. Bhanot R, Wilkinson M, 1983. Opiatergic control of LH secretion is eliminated by gonadectomy. Endocrinology 112:399–401PubMedCrossRefGoogle Scholar
  11. Bhanot R, Wilkinson M, 1984. The inhibitory effect of opiates on gonadotrophin secretion is dependent upon gonadal steroids. J Endocrinol 102:133–41PubMedCrossRefGoogle Scholar
  12. Blake CA, Norman RL, Sawyer CH, 1972. Effects of estrogen and/or progesterone on serum and pituitary gonadotropin levels in ovariectomized rats. Proc Soc Exp Biol Med 141:1100–03PubMedGoogle Scholar
  13. Blake CA, Norman RL, Sawyer CH, 1974. Localization of the inhibitory actions of estrogen and nicotine on release of luteinizing hormone in rats. Neuroendocrinology 16:22–35PubMedCrossRefGoogle Scholar
  14. Blank MS, Fabbri A, Catt KJ, Dufau ML, 1987. Inhibition of luteinizing hormone release by morphine and endogenous opiates in cultured pituitary cells. Endocrinology 118:2097–2101CrossRefGoogle Scholar
  15. Blank MS, Panerai AE, Friesen HG, 1979. Opioid peptides modulate luteinizing hormone secretion during sexual maturation. Science 203:1129–31PubMedCrossRefGoogle Scholar
  16. Blank MS, Roberts DL, 1982. Antagonist of gonadotropin-releasing hormone blocks naloxone-induced elevations in serum LH. Neuroendocrinology 35:309–12PubMedCrossRefGoogle Scholar
  17. Blankstein J, Reyes FI, Winter JSD, Faiman C, 1981. Endorphins and the regulation of the menstrual cycle. Clin Endocrinol (Oxf) 14:287–91.CrossRefGoogle Scholar
  18. Bogovich K, Richards JS, Reichert Jr LE, 1981. Obligatory role of luteinizing hormone (LH) in the initiation of preovulatory follicular growth in the pregnant rat: specific effects of human chorionic gonadotropin and follicle-stimulating hormone on LH receptors and steroidogenesis in theca, granulosa and luteal cells. Endocrinology 109:860–67PubMedCrossRefGoogle Scholar
  19. Bridges RS, 1984. A quantitative analysis of the roles of dosage, sequence, and duration of estradiol and progesterone exposure in the regulation of maternal behavior in the rat. Endocrinology 114:930–40PubMedCrossRefGoogle Scholar
  20. Bridges RS, Goldman BD, 1975. Ovarian control of prolactin secretion during late pregnancy in the rat. Endocrinology 97:496–98PubMedCrossRefGoogle Scholar
  21. Bridges RS, Ronsheim PM, 1987. Immunoreactive beta endorphin concentrations in brain and plasma during pregnancy in rats: Possible modulation by progesterone and estradiol. Neuroendocrinology (in press)Google Scholar
  22. Brown-Grant K, 1974. Steroid hormone administration and gonadotrophin secretion in the gonadectomlzed rat. J Endocrinol 62:319–32PubMedCrossRefGoogle Scholar
  23. Brown-Grant K, Corker CS, Naftolin F, 1972. Plasma and pituitary luteinizing hormone concentrations and peripheral plasma estradiol concentration during early pregnancy and after the administration of progestational steroids in the rat. J Endocrinol 53:31–35PubMedCrossRefGoogle Scholar
  24. Bruni JF, Van Vugt D, Marshall S, Meites J, 1977. Effects of naloxone, morphine and methionine enkephalin on serum prolactin, luteinizing hormone, follicle stimulating hormone, thyroid stimulating hormone and growth hormone. Life Sci 21:461–66PubMedCrossRefGoogle Scholar
  25. Butcher RL, Collins WE, Fugo NW, 1974. Plasma concentration of LH, FSH, prolactin, progesterone, and estradiol-173 throughout the 4-day estrous cycle of the rat. Endocrinology 94:1704–08PubMedCrossRefGoogle Scholar
  26. Cacicedo L, Franco FS, 1986. Direct action of opioid peptides and naloxone on gonadotropin secretion by cultured rat anterior pituitary cells. Life Sci 38:617–25PubMedCrossRefGoogle Scholar
  27. Caligari L, Astrada JJ, Taleisnik S, 1971. Release of luteinizing hormone induced by estrogen injection into ovariectomized rats. Endocrinology 88:810–15CrossRefGoogle Scholar
  28. Camp P, Akabori A, Barraclough CA, 1985. Correlation of luteinizing hormone surges with estrogen nuclear and progestin cytosol receptors in the hypothalamus and pituitary gland II. Temporal estradiol effects. Neuroendocrinology 40:54–62PubMedCrossRefGoogle Scholar
  29. Camp P, Barraclough CA, 1985. Correlation of luteinizing hormone surges with estrogen nuclear and progestin cytosol receptors in the hypothalamus and pituitary gland I. Estradiol dose-response effects. Neuroendocrinology 40:45–53PubMedCrossRefGoogle Scholar
  30. Carson RS, Richards JS, Kahn LE, 1981. Functional and morphological differentiation of theca and granulosa cells during pregnancy in the rat: dependence on increased basal luteinizing hormone activity. Endocrinology 109:1433–41PubMedCrossRefGoogle Scholar
  31. Casper RF, Alapin-Rubillovitz S, 1985. Progestins increase endogenous opioid peptide activity in postmenopausal women. J Clin Endocrinol Metab 60:34–36PubMedCrossRefGoogle Scholar
  32. Chao CC, Moss GE, Malven PV, 1986. Direct opioid regulation of pituitary release of bovine luteinizing hormone. Life Sci 39:527–34PubMedCrossRefGoogle Scholar
  33. Cheesman KL, Chatterton Jr RT, 1982. Effects of antiprogesterone antiserum on serum and ovarian progesterone, gonadotropin secretion, and pregnancy in the rat. Endocrinology 111:564–71PubMedCrossRefGoogle Scholar
  34. Cheung CY, 1983. Prolactin suppresses luteinizing hormone secretion and pituitary responsiveness to luteinizing hormone-releasing hormone by a direct action at the pituitary. Endocrinology 113:632–38PubMedCrossRefGoogle Scholar
  35. Cicero TJ, Schainker BA, Meyer ER, 1979. Endogenous opioids participate in the regulation of the hypothalamic-pituitary-luteinizing hormone axis and testosterone’s negative feedback control of luteinizing hormone. Endocrinology 104:1286–91PubMedCrossRefGoogle Scholar
  36. Cicero TJ, Schmoeker PF, Meyer ER, Miller BT, 1985. Luteinizing hormone releasing hormone mediates naloxone’s effects on serum luteinizing hormone levels in normal and morphine-sensitized male rats. Life Sci 37:467–74PubMedCrossRefGoogle Scholar
  37. Cicero TJ, Wilcox CE, Bell RD, Meyer ER, 1980. Naloxone-Induced increases in serum luteinizing hormone in male: mechanisms of action. J Pharm Exp Ther 212:573–78Google Scholar
  38. Clarke IJ, Cummins JT, 1982. The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. Endocrinology 111:1737–39PubMedCrossRefGoogle Scholar
  39. Cooper KJ, Fawcett CP, McCann SM, 1973. Variations in pituitary responsiveness to luteinizing hormone-releasing factor during the rat estrous cycle. J Endocrinol 57:187–88PubMedCrossRefGoogle Scholar
  40. Crowley WR, 1982. Effects of ovarian hormones on norepinephrine and dopamine turnover in individual hypothalamic and extrahypothalamic nuclei. Neuroendocrinology 34:381–86PubMedCrossRefGoogle Scholar
  41. DePaolo LV, Shander D, Wise PM, Barraclough CA, Channing CP, 1979. Identification of inhibin-like activity in ovarian venous plasma of rats during the estrous cycle. Endocrinology 105:647–54PubMedCrossRefGoogle Scholar
  42. Devorshak-Harvey E, Bona-Gallo A, Gallo RV, 1987a. The relationship between declining plasma progesterone levels and increasing LH pulse frequency in late gestation in the rat. Endocrinology 120:1597–1601CrossRefGoogle Scholar
  43. Devorshak-Harvey E, Bona-Gallo A, Gallo RV, 1987b. Endogenous opioid peptide regulation of pulsatile luteinizing hormone secretion during pregnancy in the rat. Neuroendocrinology (in press)Google Scholar
  44. Devorshak-Harvey E, Peluso JJ, Bona-Gallo A, Gallo RV, 1985. Effect of alterations In pulsatile luteinizing hormone release on ovarian follicular atresia and steroid secretion on diestrus 1 in the rat estrous cycle. Biol Reprod 33:103–11PubMedCrossRefGoogle Scholar
  45. Dluzen DE, Ramirez VD, 1986. In vivo measurement of LHRH and neurotransmitters from the anterior pituitary gland of castrated rats with push-pull cannulae (PPC). 1st International Congress of Neuroendocrinology, San Francisco, CA, p. 26 (Abst 13)Google Scholar
  46. Docke F, Rohde W, Gerber P, Chaovi R, Dorner G, 1984. Varying sensitivity to the negative oestrogen feedback during the ovarian cycle of female rats: evidence for the involvement of oestrogen and the medial preoptic area. J Endocrinol 102:287–94PubMedCrossRefGoogle Scholar
  47. Dupont A, Barden N, Cusan L, Merand Y, Labrie F, Vaudry H, 1980. β-endorphin and met-enkephalin: their distribution, modulation by estrogens and haloperidol, and role in neuroendocrine control. Fed Proc 39:2544–50Google Scholar
  48. Erickson, GF, Hsueh AJW, 1978. Secretion of ‘inhibin’ in rat granulosa cells in vitro. Endocrinology 103:1960–63PubMedCrossRefGoogle Scholar
  49. Eskay RL, Mical RS, Porter JC, 1977. Relationship between luteinizing hormone releasing hormone concentration in hypophysial portal blood and luteinizing hormone release in intact, castrated, and electrochemically stimulated rats. Endocrinology 100:263–70PubMedCrossRefGoogle Scholar
  50. Ferin MA, Tempone A, Zimmering PA, Vande Wiele RL, 1969. Effect of antibodies to 17β-estradiol and progesterone on the estrous cycle of the rat. Endocrinology 85:1070–78PubMedCrossRefGoogle Scholar
  51. Ferin M, Van Vugt DA, Wardlaw S, 1984. The hypothalamic control of the menstrual cycle and the role of endogenous opioid peptides. In: Greep RO (ed.), Recent Progress in Hormone Research, vol 40. New York: Academic Press, pp. 441–85Google Scholar
  52. Forman LJ, Marquis DE, Stevens R, 1985. The effect of chronic estrogen treatment on immunoreactive β-endorphin levels in intact female rats. Proc Soc Exp Biol Med 179:365–72PubMedGoogle Scholar
  53. Fox SR, Shivers BD, Harlan RE, Pfaff DW, 1986. Gonadotrophs and β-endorphin-immunoreactive neurons contain progesterone receptors, but luteinizing hormone releasing hormone-immunoreactive neurons do not. Biol Reprod 34:62 (Abst 25)Google Scholar
  54. Fox SR, Smith MS, 1985. Changes in the pulsatile pattern of luteinizing hormone secretion during the rat estrous cycle. Endocrinology 116:1485–92PubMedCrossRefGoogle Scholar
  55. Freeman MC, Dupke KC, Croteau CM, 1976. Extinction of the estrogen-induced daily signal for LH release in the rat: a role for the proestrous surge of progesterone. Endocrinology 99:223–29PubMedCrossRefGoogle Scholar
  56. Fujii T, Hoover DJ, Channing CP, 1983. Changes in inhibin activity, and progesterone, oestrogen, and androstenedione concentrations in rat follicular fluid throughout the oestrous cycle. J Reprod Fertil 69:307–14PubMedCrossRefGoogle Scholar
  57. Gabriel SM, Simpkins JW, Kalra SP, 1983. Modulation of endogenous opioid influence on luteinizing hormone secretion by progesterone and estrogen. Endocrinology 113:1806–11PubMedCrossRefGoogle Scholar
  58. Gallo RV, 1981. Pulsatile LH release during periods of low level LH secretion in the rat estrous cycle. Biol Reprod 24:771–77PubMedCrossRefGoogle Scholar
  59. Gallo RV, Bona-Gallo A, 1985. Lack of ovarian steroid negative feedback on pulsatile LH release between estrus and diestrus 1 in the rat estrous cycle. Endocrinology 116:1525–28PubMedCrossRefGoogle Scholar
  60. Gallo RV, Devorshak-Harvey E, Bona-Gallo A, 1985. Pulsatile luteinizing hormone release during pregnancy in the rat. Endocrinology 116:2637–42PubMedCrossRefGoogle Scholar
  61. Goodman RL, 1978. A quantitative analysis of the physiological role of estradiol and progesterone in the control of tonic and surge secretion of luteinizing hormone in the rat. Endocrinology 102:142–50PubMedCrossRefGoogle Scholar
  62. Goodman RL, Daniel K, 1985. Modulation of pulsatile luteinizing hormone secretion by ovarian steroids in the rat. Biol Reprod 32:217–25PubMedCrossRefGoogle Scholar
  63. Goodman RL, Karsch FJ, 1980. Pulsatile secretion of luteinizing hormone: differential suppression by ovarian steroids. Endocrinology 107:1286–90PubMedCrossRefGoogle Scholar
  64. Greenwald GS, Johnson DC, 1968. Gonadotropic requirements for the maintenance of pregnancy in the hypophysectomized rat. Endocrinology 83:1052–64PubMedCrossRefGoogle Scholar
  65. Higuchi T, Kawakami M, 1982. Changes in the characteristics of pulsatile luteinizing hormone secretion during the oestrous cycle and after ovariectomy and estrogen treatment in female rats. J Endocrinol 94:177–82PubMedCrossRefGoogle Scholar
  66. Ieiri T, Chen HT, Meites J, 1979. Effects of morphine and naloxone on serum levels of luteinizing hormone and prolactin in prepubertal male and female rats. Neuroendocrinology 29:288–92PubMedCrossRefGoogle Scholar
  67. Kalra PS, Crowley WR, Kalra SP, 1987. Differential in vitro stimulation by naloxone and K of luteinizing hormone-releasing hormone and catecholamine release from the hypothalami of intact and castrated rats. Endocrinology 120:178–85PubMedCrossRefGoogle Scholar
  68. Kalra SP, 1975. Observation on the facilitation of the preovulatory rise of LH by estrogen. Endocrinology 96:23–28PubMedCrossRefGoogle Scholar
  69. Kalra SP, 1981. Neural loci involved in naloxone-induced luteinizing hormone release: effects of a norepinephrine synthesis inhibitor. Endocrinology 109:1805–10PubMedCrossRefGoogle Scholar
  70. Kalra SP, 1983. Opioid peptides-inhibitory neuronal systems in regulation of gonadotropin secretion. In: McCann SM, Dhindsa DS (eds.), Role of Peptides and Proteins in Control of Reproduction. New York: Elsevier Biomedical, pp. 63–88Google Scholar
  71. Kalra SP, 1986. Neural circuitry involved in the control of LHRH secretion: a model for preovulatory LH release. In: Ganong WF, Martini L (eds.), Frontiers in Neuroendocrinology, vol. 9, New York: Raven Press, pp. 31–75Google Scholar
  72. Kalra SP, Kalra PS, 1974a. Effects of circulating estradiol during the rat estrous cycle on LH release following electrochemical stimulation of preoptic brain or administration of synthetic LRF. Endocrinology 94:845–51CrossRefGoogle Scholar
  73. Kalra SP, Kalra PS, 1974b. Temporal interrelationships among circulating levels of estradiol, progesterone and LH during the rat estrous cycle: effects of exogenous progesterone. Endocrinology 95:1711–18CrossRefGoogle Scholar
  74. Kalra SP, Kalra PS, 1984. Opioid-adrenergic-steroid connections in regulation of luteinizing hormone secretion in the rat. Neuroendocrinology 38:418–26PubMedCrossRefGoogle Scholar
  75. Kalra SP, Simpkins JW, 1981. Evidence for noradrenergic mediation of opioid effects on luteinizing hormone secretion. Endocrinology 109:776–82PubMedCrossRefGoogle Scholar
  76. Kinoshita F, Nakai Y, Katakami H, Kato Y, Yajima H, Imura H, 1980. Effect of β-endorphin on pulsatile luteinizing hormone release in conscious castrated rats. Life Sci 27:843–46PubMedCrossRefGoogle Scholar
  77. Krey LC, Parsons B, 1982. Characterization of estrogen stimuli sufficient to initiate cyclic luteinizing hormone release in acutely ovariectomized rats. Neuroendocrinology 34:315–22PubMedCrossRefGoogle Scholar
  78. Leadem CA, Crowley WR, Simpkins JW, Kalra SP, 1985. Effects of naloxone on catecholamine and LHRH release from the perifused hypothalamus of the steroid-primed rat. Neuroendocrinology 40:497–500PubMedCrossRefGoogle Scholar
  79. Leadem CA, Kalra SP, 1985. Effects of endogenous opioid peptides and opiates on luteinizing hormone and prolactin secretion in ovariectomized rats. Neuroendocrinology 41:342–52PubMedCrossRefGoogle Scholar
  80. Legan S, Coon GA, Karsch FJ, 1975. Role of estrogen as initiator of daily LH surges in the ovariectomized rat. Endocrinology 96:50–56PubMedCrossRefGoogle Scholar
  81. Legan S, Karsch F, 1975. A daily signal for the LH surge in the ovariectomized rat. Endocrinology 96:57–62PubMedCrossRefGoogle Scholar
  82. Leipheimer RE, Bona-Gallo A, Gallo RV, 1984. The influence of progesterone and estradiol on the acute changes in pulsatile luteinizing hormone release induced by ovariectomy in diestrous day 1 in the rat. Endocrinology 114:1605–12PubMedCrossRefGoogle Scholar
  83. Leipheimer RE, Bona-Gallo A, Gallo RV, 1985. Ovarian steroid regulation of pulsatile LH release during the interval between the mornings of diestrus 2 and proestrus in the rat. Neuroendocrinology 41:252–57PubMedCrossRefGoogle Scholar
  84. Leipheimer RE, Bona-Gallo A, Gallo RV, 1986a. Ovarian steroid regulation of basal pulsatile LH release between the mornings of proestrus and estrus in the rat. Endocrinology 118:2083–90CrossRefGoogle Scholar
  85. Leipheimer RE, Bona-Gallo A, Gallo RV, 1986b. Influence of estradiol and progesterone on pulsatile LH secretion in 8-day ovarlectomized rats. Neuroendocrinology 43:300–07CrossRefGoogle Scholar
  86. Leipheimer RE, Gallo RV, 1983. Acute and long-term changes in central and pituitary mechanisms regulating pulsatile luteinizing hormone secretion after ovariectomy in the rat. Neuroendocrinology 37:421–26PubMedCrossRefGoogle Scholar
  87. Levine JE, Pau K-YF, Ramirez VD, Jackson GL, 1982. Simultaneous measurement of luteinizing hormone-releasing hormone and luteinizing hormone release in unanesthetized, ovarlectomized sheep. Endocrinology 111:1449–55PubMedCrossRefGoogle Scholar
  88. Levine JE, Ramirez VD, 1982. Luteinizing hormone-releasing hormone release during the rat estrous cycle and after ovariectomy, as estimated with push- pull cannulae. Endocrinology 111:1439–48PubMedCrossRefGoogle Scholar
  89. Linkie DM, Niswender GD, 1972. Serum levels of prolactin, luteinizing hormone and follicle stimulating hormone during pregnancy in the rat. Endocrinology 90:632–37PubMedCrossRefGoogle Scholar
  90. Loewit K, Badawy S, Laurence K, 1969. Alteration of corpus luteum function in the pregnant rat by antiluteinizing serum. Endocrinology 84:244–51PubMedCrossRefGoogle Scholar
  91. Lumpkin MD, DePaolo LV, Negro-Vilar A, 1984. Pulsatile release of follicle-stimulating hormone in ovarlectomized rats is inhibited by porcine follicular fluid (inhibin). Endocrinology 114:201–06PubMedCrossRefGoogle Scholar
  92. Malven PV, Bossut DFB, Diekman MA, 1984. Effects of naloxone and electroacupuncture treatment on plasma concentrations of LH in sheep. J Endocrinol 101:75–80PubMedCrossRefGoogle Scholar
  93. Mano A, 1983. Pituitary responsiveness to luteinizing hormone releasing hormone during pregnancy in the rat. Acta Obstet Gynec Jpn 35:1649 – 52Google Scholar
  94. McCann SM, 1962. Effect of progesterone on plasma luteinizing hormone activity. Am J Physiol 202:601–04Google Scholar
  95. McGinnis MY, Krey LC, MacLusky NJ, McEwen BS, 1981. Steroid receptor levels in intact and ovarlectomized estrogen-treated rats: an examination of quantitative, temporal and endocrine factors influencing the efficacy of an estradiol stimulus. Neuroendocrinology 33:158–65PubMedCrossRefGoogle Scholar
  96. McPherson III JC, Costoff A, Mahesh VB, 1975. Influence of estrogen-progesterone combinations on gonadotropin secretion in castrate female rats. Endocrinology 97:771–79PubMedCrossRefGoogle Scholar
  97. Meites J, Bruni JF, Van Vugt DA, Smith AF, 1979. Relation of endogenous opioid peptides and morphine to neuroendocrine functions. Life Sci 24:1325–36PubMedCrossRefGoogle Scholar
  98. Meites J, Van Vugt DA, Forman LJ, Sylvester Jr PW, Ieiri T, Sonntag W, 1983. Evidence that endogenous opiates are involved in control of gonadotropin secretion. In: Bhatnager AS (ed.), Anterior Pituitary Gland. New York: Raven Press, pp 327–40Google Scholar
  99. Melis GB, Paoletti AM, Gambacciani M, Mais V, Fioretti P, 1984. Evidence that estrogens inhibit LH secretion through opioids in postmenopausal women using naloxone. Neuroendocrinology 39:60–63PubMedCrossRefGoogle Scholar
  100. Miyake A, Terakawa N, Tasaka K, Shimizu I, Ohtsuka S, Lee J-W, Aono T, 1985. Prolactin inhibits oestradiol-induced luteinizing hormone release at the pituitary level. Acta Endocrinol 109:204–07PubMedGoogle Scholar
  101. Morishige WK, Pepe GJ, Rothchild I, 1973. Serum luteinizing hormone, prolactin and progesterone levels during pregnancy in the rat. Endocrinology 92:1527–30PubMedCrossRefGoogle Scholar
  102. Morrell JI, McGinty JF, Pfaff DW, 1985. A subset of β-endorphin- or dynorphin-containing neurons in the medial basal hypothalamus accumulates estradiol. Neuroendocrinology 41:417–26PubMedCrossRefGoogle Scholar
  103. Moudgal NR, 1969. Effect of ICSH on early pregnancy in hypophysectomized pregnant rats. Nature 222:286–87PubMedCrossRefGoogle Scholar
  104. Negro-Vilar A, 1973. Interaction between gonadal steroids and LH-releasing hormone to control gonadotropin secretion at the pituitary level. Acta Physiol Latinoam 23:494–96Google Scholar
  105. Nequin LG, Alvarez J, Schwartz NB, 1979. Measurements of serum steroid and gonadotropin levels and uterine and ovarian variables throughout 4-day and 5-day estrous cycles in the rat. Biol Reprod 20:659–70PubMedCrossRefGoogle Scholar
  106. Panerai AE, Martini A, Casanueva F, Petraglia F, DiGiulio AM, Mantegazza P, 1983. Opiates and their antagonists modulate luteinizing hormone acting outside the blood brain barrier. Life Sci 32:1751–56PubMedCrossRefGoogle Scholar
  107. Pau K-YF, Orstead KM, Hess DL, Spies HG, 1986. Feedback effects of ovarian steroids on the hypothalamic-hypophyseal axis in the rabbit. Biol Reprod 35:1009–23PubMedCrossRefGoogle Scholar
  108. Pencharz RI, Long JA, 1933. Hypophysectomy in the pregnant rat. Am J Anat 53:117–39CrossRefGoogle Scholar
  109. Petraglia F, Baraldi M, Giarre G, Facchinetti F, Santi M, Volpe A, Genazzani AR, 1985. Opioid peptides of the pituitary and hypothalamus: changes in pregnant and lactating rats. J Endocrinol 105:239–45PubMedCrossRefGoogle Scholar
  110. Petraglia F, Locatelli V, Facchinetti F, Bergamaschi M, Genazzani AR, Cocchi D, 1986. Oestrous cycle-related LH responsiveness to naloxone: effect of high oestrogen levels on the activity of opioid receptors. J Endocrinol 108:89–94PubMedCrossRefGoogle Scholar
  111. Petraglia F, Locatelli V, Penalva A, Cocchi D, Genazzani AR, Muller EE, 1984. Gonadal steroid modulation of naloxone-induced LH secretion in the rat. J Endocrinol 101:33–39PubMedCrossRefGoogle Scholar
  112. Piva F, Maggi R, Limonta P, Martini L, 1986. Effect of naloxone on luteinizing hormone, follicle stimulating hormone, and prolactin secretion in the different phases of the estrous cycle. Endocrinology 117:766–72CrossRefGoogle Scholar
  113. Quigley ME, Yen SSC, 1980. The role of endogenous opiates on LH secretion during the menstrual cycle. J Clin Endocrinol Metab 51:179–81PubMedCrossRefGoogle Scholar
  114. Raj HGM, Moudgal NR, 1970. Hormonal control of gestation in the rat. Endocrinology 86:874–89PubMedCrossRefGoogle Scholar
  115. Raj HGM, Talbert LM, Easterling WE, Dym RC, 1979. Role of pituitary LH and placenta in luteal progesterone production and maintenance of pregnancy in the rat. Adv Exp Med Biol 112:535–40PubMedGoogle Scholar
  116. Rasmussen DD, Liu JH, Wolf PL, Yen SSC, 1983. Endogenous opioid regulation of gonadotropin-releasing hormone release from the human fetal hypothalamus in vitro. J Clin Endocrinol Metab 57:881–84PubMedCrossRefGoogle Scholar
  117. Rivier J, Spiess J, McClintock R, Vaughan J, Vale W, 1985. Purification and partial characterization of inhibin from porcine follicular fluid. Biochem Biophys Res Commun 133:120–27PubMedCrossRefGoogle Scholar
  118. Ropert JF, Quigley ME, Yen SSC, 1981. Endogenous opiates modulate pulsatile luteinizing hormone release in humans. J Clin Endocrinol Metab 52:583–85PubMedCrossRefGoogle Scholar
  119. Sander HJ, Van Leeuwen ECM, Jong FH de, 1984. Inhibin-like activity in media from cultured rat granulosa cells collected throughout the estrous cycle. J Endocrinol 103:77–84PubMedCrossRefGoogle Scholar
  120. Sarkar DK, Fink G, 1980. Luteinizing hormone-releasing factor in pituitary stalk plasma from long-term ovariectomized rats: effects of steroids. J Endocrinol 86:511–24PubMedCrossRefGoogle Scholar
  121. Sarkar DK, Yen SSC, 1985. Changes in β-endorphin-like immunoreactivity in pituitary portal blood during the estrous cycle and after ovariectomy in rats. Endocrinology 116:2075–79PubMedCrossRefGoogle Scholar
  122. Smith MS, Freeman ME, Neill JD, 1975. The control of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat: prolactin, gonadotropin, and steroid levels associated with rescue of the corpus luteum of pseudopregnancy. Endocrinology 96:219–26PubMedCrossRefGoogle Scholar
  123. Smith MS, Neill JD, 1976. Termination at mid-pregnancy of the two daily surges of plasma prolactin initiated by mating in the rat. Endocrinology 98:696–701PubMedCrossRefGoogle Scholar
  124. Snowden EU, Khan-Dawood FS, Dawood MY, 1984. The effect of naloxone on endogenous opioid regulation of pituitary gonadotropins and prolactin during the menstrual cycle. J Clin Endocrinol Metab 59:298–302PubMedCrossRefGoogle Scholar
  125. Soules MR, Steiner RA, Clifton DK, Cohen NL, Askel S, Bremner WJ, 1984. Progesterone modulation of pulsatile luteinizing hormone secretion in normal women. J Clin Endocrinol Metab 58:378–83PubMedCrossRefGoogle Scholar
  126. Sylvester PW, Van Vugt DA, Aylsworth CA, Hanson EA, Meites J, 1982. Effects of morphine and naloxone on inhibition by ovarian hormones of pulsatile release of LH in ovariectomized rats. Neuroendocrinology 34:269–73PubMedCrossRefGoogle Scholar
  127. Taya K, Greenwald G, 1981. In vivo and in vitro ovarian steroidogenesis in the pregnant rat. Biol Reprod 25:683–91PubMedCrossRefGoogle Scholar
  128. Terranova PF, Greenwald GS, 1981. Acute effects of an antiserum to luteinizing hormone on ovarian steroidogenesis in the pregnant rat. J Endocrinol 90:19–30PubMedCrossRefGoogle Scholar
  129. Turgeon JL, Barraclough CA, 1974. Pulsatile plasma LH rhythms in normal and androgen-sterilized ovariectomized rats: effects of estrogen treatment. Proc Soc Exp Biol Med 145:821–25PubMedGoogle Scholar
  130. Van Vugt DA, Bakst G, Dyrenfurth I, Ferin M, 1983. Naloxone stimulation of luteinizing hormone secretion in the female monkey: influence of endocrine and experimental conditions. Endocrinology 113:1858–64PubMedCrossRefGoogle Scholar
  131. Van Vugt DA, Lam NY, Ferin M, 1984. Reduced frequency of pulsatile luteinizing hormone secretion in the luteal phase of the Rhesus monkey: involvement of endogenous opiates. Endocrinology 115:1095–01PubMedCrossRefGoogle Scholar
  132. Van Vugt DA, Sylvester PW, Aylsworth CF, Meites J, 1982. Counteraction of gonadal steroid inhibition of luteinizing hormone release by naloxone. Neuroendocrinology 34:274–78PubMedCrossRefGoogle Scholar
  133. Veldhuis JD, Rogol AD, Samojlik E, Ertel NH, 1984. Role of endogenous opiates in the expression of negative feedback actions of androgen and estrogen on pulsatile properties of luteinizing hormone secretion in man. J Clin Invest 74:47–55PubMedCrossRefGoogle Scholar
  134. Voogt J, Robertson M, Friesen H, 1982. Inverse relationship of prolactin and placental lactogen during pregnancy. Biol Reprod 26:800–05PubMedCrossRefGoogle Scholar
  135. Wardlaw SL, Frantz AG, 1983. Brain β-endorphin during pregnancy, parturition and the postpartum period. Endocrinology 113:1664–68PubMedCrossRefGoogle Scholar
  136. Wardlaw SL, Thoron L, Frantz AG, 1982a. Effects of sex steroids on brain β-endorphin. Brain Res 245:327–31PubMedCrossRefGoogle Scholar
  137. Wardlaw SL, Wang PJ, Frantz AG, 1985. Regulation of β-endorphin and ACTH in brain by estradiol. Life Sci 37:1941–47PubMedCrossRefGoogle Scholar
  138. Wardlaw SL, Wehrenberg WB, Ferin M, Antunes JL, Frantz AG, 1982b. Effect of sex steroids on β-endorphin in hypophyseal portal blood. J Clin Endocrinol Metab 55:877–81CrossRefGoogle Scholar
  139. Wehrenberg WB, Wardlaw SL, Frantz AG, Ferin M, 1982. β-endorphin in hypophyseal portal blood: variations throughout the menstrual cycle. Endocrinology 111:879–81Google Scholar
  140. Weick RF, 1977. Effects of estrogen and progesterone on pulsatile discharges of luteinizing hormone in the ovariectomized rat. Can J Physiol Pharmacol 55:226–33PubMedCrossRefGoogle Scholar
  141. Weick RF, Noh KA, 1984. Inhibitory effects of estrogen and progesterone on several parameters of pulsatile LH release in the ovariectomized rat. Neuroendocrinology 38:351–56PubMedCrossRefGoogle Scholar
  142. Wiesner JB, Koenig JI, Krulich L, Moss RL, 1984. Site of action for β-endorphin-induced changes in plasma luteinizing hormone and prolactin in the ovariectomized rat. Life Sci 34:1463–73PubMedCrossRefGoogle Scholar
  143. Wilcox JN, Roberts JL, 1985. Estrogen decreases rat hypothalamic proopiomelanocortin messenger ribonucleic acid levels. Endocrinology 117:2392–96PubMedCrossRefGoogle Scholar
  144. Wilkes MM, Yen SSC, 1981. Augmentation by naloxone of efflux of LRF from superfused medial basal hypothalamus. Life Sci 28:2355–59PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • R. V. Gallo
    • 1
  • G. N. Babu
    • 1
  • A. Bona-Gallo
    • 1
  • E. Devorshak-Harvey
    • 1
  • R. E. Leipheimer
    • 1
  • J. Marco
    • 1
  1. 1.Department of Physiology and NeurobiologyThe University of ConnecticutStorrsUSA

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