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Stereochemical Complementarity between Antiestrogens and DNA

  • L. B. Hendry
  • T. G. Muldoon
  • V. B. Mahesh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 219)

Abstract

Why do relatively few small molecules exist in nature in comparison to the almost infinite number of structures which are conceivable? The answer to this question appears to lie in the discovery of stereochemical complementarity of nucleic acids and a variety of natural products (Hendry et al., 1977). Small molecules which exist in nature exhibit complementarity. Small molecules which do not exhibit complementarity do not exist in nature.

Keywords

Estrogen Antagonist Operational Criterion Major Groove Candidate Molecule Hormonal Steroid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Hendry LB, Bransome ED Jr, Hutson MS, Campbell LK, 1984a. A newly discovered stereochemical logic in the structure of DNA suggests that the genetic code is inevitable. Perspect Biol Med 27:623–651PubMedGoogle Scholar
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • L. B. Hendry
    • 1
    • 2
  • T. G. Muldoon
    • 1
    • 2
  • V. B. Mahesh
    • 1
    • 2
  1. 1.Departments of Medicine, Physiology and EndocrinologyMedical College of GeorgiaAugustaUSA
  2. 2.Stereochemical Genetics, Inc.AugustaUSA

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