Stereochemical Complementarity between Antiestrogens and DNA
Why do relatively few small molecules exist in nature in comparison to the almost infinite number of structures which are conceivable? The answer to this question appears to lie in the discovery of stereochemical complementarity of nucleic acids and a variety of natural products (Hendry et al., 1977). Small molecules which exist in nature exhibit complementarity. Small molecules which do not exhibit complementarity do not exist in nature.
KeywordsEstrogen Antagonist Operational Criterion Major Groove Candidate Molecule Hormonal Steroid
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