Transmembrane Signals and Intracellular Messengers Mediating LHRH and LH Secretion

  • A. Negro-Vilar
  • M. M. Valenca
  • M. D. Culler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 219)


The gametogenic and endocrine functions of the gonads are both under the integrative control of the central nervous system. The primary regulatory component in this system is the hypothalamic peptide luteinizing hormone-releasing hormone (LHRH), a decapeptide produced by neurons located in the hypothalamic-preoptic region. After synthesis, LHRH is transported to nerve terminals located in the median eminence, where it is released in close proximity to portal capillaries. The decapeptide is then transported to the anterior pituitary gland through the hypophyseal portal circulation, where, acting on specific membrane receptors, it stimulates LH and FSH secretion. These gonadotropins, in turn, profoundly affect gonadal function.


Arachidonic Acid Median Eminence Luteinizing Hormone Release Hormone Intracellular Messenger Inositol Phospholipid 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • A. Negro-Vilar
    • 1
  • M. M. Valenca
    • 1
  • M. D. Culler
    • 1
  1. 1.Reproductive Neuroendocrinology Section, LRDT, National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle ParkUSA

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