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The Effect of Prostaglandin F on Relaxin Release Differs in the Cyclic and Pregnant Sow

  • C. A. Bagnell
  • J. P. McMurtry
  • G. S. Lewis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 219)

Abstract

Relaxin is known classically as a hormone of pregnancy with high levels produced by the corpus luteum (CL) of the sow. However, recently relaxin has been localized in luteal tissue of the pseudopregnant pig (Fields and Fields, 1985) and in the nonpregnant pig throughout the cycle (Ali et al., 1986). Luteal relaxin immunoactivity was highest from days 7 to 15 of the cycle with a decline by day 18 coincident in time with luteolysis, defined functionally as a decline in serum progesterone and occurring between days 14 and 18 of the sow estrous cycle (Cavazos et al., 1969). Whether prostaglandin F (PGF), postulated as the major signal for luteolysis in this species (Moeljono et al., 1976), is also responsible for relaxin release from the CL of the cycle is not known and was an objective in this study using exogenous prostaglandin.

Keywords

Corpus Luteum Estrous Cycle Serum Progesterone Ovarian Artery Luteal Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Afele S, Bryant-Greenwood GD, Chamley WA, Dax EM, 1979. Plasma relaxin immunoactivity in the pig at parturition and during nuzzling and suckling. J Reprod Fert 56:451–7CrossRefGoogle Scholar
  2. Ali SM, McMurtry JP, Bagnell CA, Bryant-Greenwood GD, 1986. Immunocyto-chemical localization of relaxin in corpora lutea of sows throughout the estrous cycle. Biol Reprod 34:139–43PubMedCrossRefGoogle Scholar
  3. Anderson LL, Ford JJ, Melampy RM, Cox DF, 1973. Relaxin in porcine corpora lutea during pregnancy and after hysterectomy. Am J Physiol 225(5):1215–9PubMedGoogle Scholar
  4. Bryant-Greenwood GD, Greenwood FC, 1979. Specificity of radioimmunoassay for relaxin. J Endocrinol 81:239–47PubMedCrossRefGoogle Scholar
  5. Cavazos LF, Anderson LL, Belt WD, Hendricks DM, Kraeling RR, Melampy RM, 1969. Fine structure and progesterone in the corpus luteum of the pig during the estrous cycle. Biol Reprod 1:83–106PubMedCrossRefGoogle Scholar
  6. Diehl JR, Day BN, 1974. Effect of prostaglandin F on luteal function in swine. J Anim Sci 39:392–6PubMedGoogle Scholar
  7. Douglas RH, Ginther OJ, 1975. Effect of prostaglandin F on estrous cycle or corpus luteum in mares and gilts. J Anim Sci 40:518–21PubMedGoogle Scholar
  8. Fields PA, Fields MJ, 1985. Ultrastructural localization of relaxin in the corpus luteum of the nonpregnant, pseudopregnant, and pregnant pig. Biol Reprod 32:1169–79PubMedCrossRefGoogle Scholar
  9. Gomes WR, Herschier RC, Erb RE, 1965. Progesterone levels in ovarian venous effluent of the non-pregnant sow. J Anim Sci 24:722–7PubMedGoogle Scholar
  10. Guthrie HD, 1977. Induction of ovulation and fertility in prepubertal gilts. J Anim Sci 45:1360–7PubMedGoogle Scholar
  11. Hsu SM, Raine L, Fanger H, 1981. The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:557–80Google Scholar
  12. Moeljono MPE, Bazer FW, Thatcher WW, 1976. A study of prostaglandin F as the luteolysin in swine: I. Effect of prostaglandin F in hysterectomized gilts. Prostaglandins 1:737–43CrossRefGoogle Scholar
  13. Nara BS, Ball GD, Rutherford JE, Sherwood OD, First NL, 1982. Release of relaxin by a nonluteolytic dose of prostaglandin F2 in pregnant swine. Biol Reprod 27:1190–5PubMedCrossRefGoogle Scholar
  14. Sherwood OD, Chang CC, BeVier GW, Diehl JR, Dziuk PJ, 1976. Relaxin concentrations in pig plasma following the administration of prostaglandin F during late pregnancy. Endocrinology 98:875–9PubMedCrossRefGoogle Scholar
  15. Sherwood OD, Nara BS, Crnekovic VE, First NL, 1979. Relaxin concentrations in pig plasma after the administration of indomethacin and prostaglandin F during late pregnancy. Endocrinology 104:1716–21PubMedCrossRefGoogle Scholar
  16. Vaitukaitis JL, Robbins JB, Nieschlag E, Ross GT, 1971. A method for producing specific antisera with small doses of immunogen. J Clin Endocrinol Metab 33:988–91PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • C. A. Bagnell
    • 1
  • J. P. McMurtry
    • 2
  • G. S. Lewis
    • 3
  1. 1.Pacific Biomedical Research CenterUniversity of HawaiiHonoluluUSA
  2. 2.Nonruminant Nutrition, Animal Science InstituteUSDA, Agricultural Research ServiceBeltsvilleUSA
  3. 3.Reproduction Labs, Animal Science InstituteUSDA, Agricultural Research ServiceBeltsvilleUSA

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