The Effect of Prostaglandin F on Relaxin Release Differs in the Cyclic and Pregnant Sow

  • C. A. Bagnell
  • J. P. McMurtry
  • G. S. Lewis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 219)


Relaxin is known classically as a hormone of pregnancy with high levels produced by the corpus luteum (CL) of the sow. However, recently relaxin has been localized in luteal tissue of the pseudopregnant pig (Fields and Fields, 1985) and in the nonpregnant pig throughout the cycle (Ali et al., 1986). Luteal relaxin immunoactivity was highest from days 7 to 15 of the cycle with a decline by day 18 coincident in time with luteolysis, defined functionally as a decline in serum progesterone and occurring between days 14 and 18 of the sow estrous cycle (Cavazos et al., 1969). Whether prostaglandin F (PGF), postulated as the major signal for luteolysis in this species (Moeljono et al., 1976), is also responsible for relaxin release from the CL of the cycle is not known and was an objective in this study using exogenous prostaglandin.


Corpus Luteum Estrous Cycle Serum Progesterone Ovarian Artery Luteal Tissue 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • C. A. Bagnell
    • 1
  • J. P. McMurtry
    • 2
  • G. S. Lewis
    • 3
  1. 1.Pacific Biomedical Research CenterUniversity of HawaiiHonoluluUSA
  2. 2.Nonruminant Nutrition, Animal Science InstituteUSDA, Agricultural Research ServiceBeltsvilleUSA
  3. 3.Reproduction Labs, Animal Science InstituteUSDA, Agricultural Research ServiceBeltsvilleUSA

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