Abstract
Relaxin is known classically as a hormone of pregnancy with high levels produced by the corpus luteum (CL) of the sow. However, recently relaxin has been localized in luteal tissue of the pseudopregnant pig (Fields and Fields, 1985) and in the nonpregnant pig throughout the cycle (Ali et al., 1986). Luteal relaxin immunoactivity was highest from days 7 to 15 of the cycle with a decline by day 18 coincident in time with luteolysis, defined functionally as a decline in serum progesterone and occurring between days 14 and 18 of the sow estrous cycle (Cavazos et al., 1969). Whether prostaglandin F2α (PGF2α), postulated as the major signal for luteolysis in this species (Moeljono et al., 1976), is also responsible for relaxin release from the CL of the cycle is not known and was an objective in this study using exogenous prostaglandin.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Afele S, Bryant-Greenwood GD, Chamley WA, Dax EM, 1979. Plasma relaxin immunoactivity in the pig at parturition and during nuzzling and suckling. J Reprod Fert 56:451–7
Ali SM, McMurtry JP, Bagnell CA, Bryant-Greenwood GD, 1986. Immunocyto-chemical localization of relaxin in corpora lutea of sows throughout the estrous cycle. Biol Reprod 34:139–43
Anderson LL, Ford JJ, Melampy RM, Cox DF, 1973. Relaxin in porcine corpora lutea during pregnancy and after hysterectomy. Am J Physiol 225(5):1215–9
Bryant-Greenwood GD, Greenwood FC, 1979. Specificity of radioimmunoassay for relaxin. J Endocrinol 81:239–47
Cavazos LF, Anderson LL, Belt WD, Hendricks DM, Kraeling RR, Melampy RM, 1969. Fine structure and progesterone in the corpus luteum of the pig during the estrous cycle. Biol Reprod 1:83–106
Diehl JR, Day BN, 1974. Effect of prostaglandin F2α on luteal function in swine. J Anim Sci 39:392–6
Douglas RH, Ginther OJ, 1975. Effect of prostaglandin F2α on estrous cycle or corpus luteum in mares and gilts. J Anim Sci 40:518–21
Fields PA, Fields MJ, 1985. Ultrastructural localization of relaxin in the corpus luteum of the nonpregnant, pseudopregnant, and pregnant pig. Biol Reprod 32:1169–79
Gomes WR, Herschier RC, Erb RE, 1965. Progesterone levels in ovarian venous effluent of the non-pregnant sow. J Anim Sci 24:722–7
Guthrie HD, 1977. Induction of ovulation and fertility in prepubertal gilts. J Anim Sci 45:1360–7
Hsu SM, Raine L, Fanger H, 1981. The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:557–80
Moeljono MPE, Bazer FW, Thatcher WW, 1976. A study of prostaglandin F2α as the luteolysin in swine: I. Effect of prostaglandin F2α in hysterectomized gilts. Prostaglandins 1:737–43
Nara BS, Ball GD, Rutherford JE, Sherwood OD, First NL, 1982. Release of relaxin by a nonluteolytic dose of prostaglandin F2 in pregnant swine. Biol Reprod 27:1190–5
Sherwood OD, Chang CC, BeVier GW, Diehl JR, Dziuk PJ, 1976. Relaxin concentrations in pig plasma following the administration of prostaglandin F2α during late pregnancy. Endocrinology 98:875–9
Sherwood OD, Nara BS, Crnekovic VE, First NL, 1979. Relaxin concentrations in pig plasma after the administration of indomethacin and prostaglandin F2α during late pregnancy. Endocrinology 104:1716–21
Vaitukaitis JL, Robbins JB, Nieschlag E, Ross GT, 1971. A method for producing specific antisera with small doses of immunogen. J Clin Endocrinol Metab 33:988–91
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Bagnell, C.A., McMurtry, J.P., Lewis, G.S. (1987). The Effect of Prostaglandin F2α on Relaxin Release Differs in the Cyclic and Pregnant Sow. In: Mahesh, V.B., Dhindsa, D.S., Anderson, E., Kalra, S.P. (eds) Regulation of Ovarian and Testicular Function. Advances in Experimental Medicine and Biology, vol 219. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5395-9_48
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5395-9_48
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5397-3
Online ISBN: 978-1-4684-5395-9
eBook Packages: Springer Book Archive