Action of Progesterone and RU38486 on Protein Synthesis in Rat Placenta
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 219)
Progesterone action in maintenance of pregnancy includes inhibition of myometrial contractility and local suppression of the maternal immune system. In addition to these actions, this study indicates that progesterone (P) also directly maintains placental function. We propose that this action is mediated by the placental nuclear progesterone receptor (Rpn) characterized previously (Ogle, 1986a,b). This study examines the effects of ovariectomy (OVX) and the antiprogestin, RU38486 (RU), on the Rpn and on the regulation of protein synthesis. Capacity for protein synthesis is used in this report as a physiological indicator of placental function.
KeywordsPlacental Tissue Sodium Molybdate Placental Function Uterine Contractility Maternal Immune System
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Plenum Press, New York 1987