The Steroid-Neuropeptide Connection in the Control of LHRH Secretion

  • S. P. Kalra
  • P. S. Karla
  • A. Sahu
  • L. G. Allen
  • W. R. Crowley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 219)


The concept that hormonal secretions of the gonads are the primary signals that drive and sustain the intricate balance within the closed feedback loop of the hypothaiamo-pituitary-gonadal axis is well established. In 1932, Moore and Price proposed that a tight reciprocal relationship between the gonad and the pituitary was responsible for maintaining gonadal function in the adult rat (Fig. 1). Intensive investigations over the intervening years have affirmed the broad outline of this gonad-pituitary “push-pull” operation. The secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) is generally restrained to a low basal range in intact rats, and in the absence of the gonadal feedback signals, as exemplified by gonadectomy, gonadotropins are secreted at augmented rates. It is apparent that gonadal steroids do not inhibit LH release by directly restraining the release of LH from the pituitary gonadotrophs but they monitor the response of gonadotrophs to luteinizing hormone releasing hormone (LHRH), the hypothalamic humoral signal secreted in episodic fashion. Further, the evidence suggests that androgens in male rats and a combined milieu of estradiol-17β (E2) and progesterone (P) in female rats diminish, while E2 in the absence of P, facilitate the LHRH-induced LH release.


Luteinizing Hormone Gonadal Steroid Luteinizing Hormone Surge Luteinizing Hormone Secretion Medial Basal Hypo 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • S. P. Kalra
    • 1
  • P. S. Karla
    • 1
  • A. Sahu
    • 1
  • L. G. Allen
    • 1
  • W. R. Crowley
    • 2
  1. 1.Department of Obstetrics and GynecologyUniversity of Florida College of MedicineGainesvilleUSA
  2. 2.Department of PharmacologyUniversity of TennesseMemphisUSA

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