Induction of Follicular Cysts in Rat Ovaries by Prolonged Administration of Human Chorionic Gonadotropin
Polycystic ovarian disease (PCOD) appears to arise from an inappropriate peripubertal response within the hypothalamic-pituitary-ovarian axis. For review see Yen (1980), Coney (1984) and Futterweit (1984). The association of elevated serum concentrations of luteinizing hormone (LH), androgens and estrogens with this syndrome has led to the hypothesis that overstimulation of the ovary by LH leads to the development of ovarian follicular cysts. Pharmacologic amounts of androgens and estrogens appear capable of inducing the formation of ovarian cysts. However, such quantities of these steroids also disrupt hypothalamic-pituitary interactions (Barraclough, 1966; Shulster et al., 1984) and, therefore, the potential for these steroids to affect the development of cysts by inducing inappropriate secretion of gonadotropins cannot be ruled out. Furthermore, until now, the time- and dose-related effects of prolonged, chronic exposure to LH-like activity on ovarian follicular cyst formation had not been determined. This work was undertaken to determine: 1) if chronic administration of LH-like activity is capable of inducing the formation of cystic follicles in intact animals; and 2) if such treatment is effective in inducing cystic follicles in ovaries at different stages of development/differentiation.
KeywordsLuteinizing Hormone Granulosa Cell Human Chorionic Gonadotropin Ovarian Cyst Preovulatory Follicle
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