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On the Site of Action of the Estradiol-Induced Release of Luteinizing Hormone (LH) in Pigs

  • J. S. Kesner
  • R. R. Kraeling
  • G. B. Rampacek
  • C. R. Barb
  • M. S. Estienne
  • R. D. Kineman
  • C. E. Estienne
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 219)

Abstract

The site of action by which estradiol triggers the preovulatory LH surge varies widely among species. In sheep (Clarke and Cummins, 1984), cattle (Kesner et al., 1981) and rats (Fink, 1979), estradiol is thought to sensitize the pituitary to gonadotropin releasing hormone (GnRH) stimulation and then to accelerate the secretion rate of GnRH. In primates, estradiol stimulates the pituitary directly to occasion the LH surge (Knobil, 1980). Herein we report the effect of the pharmacological block of central nervous system (CNS) inputs on the estradiol-induced LH surge in gilts, and describe the dynamic changes in pituitary responsiveness to GnRH after estradiol exposure.

Keywords

LUTEINIZING Hormone Follicle Stimulate Hormone LUTEINIZING Hormone Surge LUTEINIZING Hormone Release GnRH Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Clarke IJ, Cummins JT, 1984. Direct pituitary effects of estrogen and progesterone on gonadotropin secretion in the ovariectomized ewe. Neuroendocrinology 39:267–274PubMedCrossRefGoogle Scholar
  2. Cox NM, Britt JH, 1982. Effect of estradiol on hypothalamic GnRH and pituitary and serum LH and FSH in ovariectomized pigs. J Anim Sci 55:901–908PubMedGoogle Scholar
  3. Docke F, Busch W, 1974. Evidence for anterior hypothalamic control of cyclic gonadotropin secretion in female pigs. Endokrinologie 63:415–421PubMedGoogle Scholar
  4. Elsaesser F, Foxcroft GR, 1978. Maturational changes in the characteristics of oestrogen-induced surges of luteinizing hormone in immature domestic gilts. J Endocrinol 78:455–456PubMedCrossRefGoogle Scholar
  5. Elsaesser F, Parvizi N, 1979. Estrogen feedback in the pig: sexual differentiation and the effect of prenatal testosterone treatment. Biol Reprod 20:1187–1193PubMedCrossRefGoogle Scholar
  6. Fink G, 1979. Feedback actions of target hormones on hypothalamus and pituitary with special reference to gonadal steroids. Ann Rev Physiol 41:571–585CrossRefGoogle Scholar
  7. Kesner JS, Convey EM, Anderson CR, 1981. Evidence that estradiol induces the preovulatory LH surge in cattle by increasing pituitary sensitivity to LHRH and then increasing LHRH release. Endocrinology 108:1386–1391PubMedCrossRefGoogle Scholar
  8. Knobil E, 1980. The neuroendocrine control of the menstrual cycle. Rec Prog Horm Res 36:53–88PubMedGoogle Scholar
  9. Malven PV, 1971. Hypothalamic sites of action for methallibure (ICI 33828) inhibition of gonadotropin secretion. J Anim Sci 32:912–918PubMedGoogle Scholar
  10. Parvizi N, Elsaesser F, Smidt D, Ellendorf F, 1976. Plasma luteinizing hormone and progesterone in the adult female pig during the estrous cycle, late pregnancy and lactation, after ovariectomy and pentobarbitone treatment. J Endocrinol 69:193–203PubMedCrossRefGoogle Scholar
  11. SAS/STAT Guide. 1985. SAS Institute Inc., Cary, NC, pp. 183–260Google Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • J. S. Kesner
    • 1
    • 2
  • R. R. Kraeling
    • 1
    • 2
  • G. B. Rampacek
    • 1
    • 2
  • C. R. Barb
    • 1
    • 2
  • M. S. Estienne
    • 1
    • 2
  • R. D. Kineman
    • 1
    • 2
  • C. E. Estienne
    • 1
    • 2
  1. 1.Animal Physiology Research Unit, R B Russell Research CenterUSDA-ARSAthensUSA
  2. 2.University of GeorgiaAthensUSA

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