Receptor-Weighted Mechanistic Approach to Analysis of the Actions of Estrogen and Progesterone on Gonadotropin Secretion

  • T. G. Muldoon
  • V. B. Mahesh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 219)


Synthesis and secretion of gonadotropins from the anterior pituitary, and the end-product regulation of these processes, represents the cornerstone of reproductive physiology; to the extent that we are lacking in a thorough basic understanding of these phenomena, the superstructure of endocrine-based manipulation of reproductive function collapses. Realization of this fact accounts for the vast number of experimental approaches which have been taken to delve ever deeper into the intricacies of the complex interrelationships involved. In the early 1970’s, we joined the ranks of a small number of groups who were actively investigating the occurrence and nature of steroid hormone receptors in the anterior pituitary (Eisenfeld, 1970; Kato, 1970; Notides, 1970; Korach and Muldoon, 1973). These analyses rapidly developed into collaborative ventures between our two laboratories (Mahesh et al., 1972), investigating correlative dependencies between estrogen receptor dynamics and gonadotropin fluctuations under similarly manipulated experimental conditions. These studies were furthered by subsequent description of the estrogen retention system in the hypothalamus (Korach and Muldoon, 1974).


Estrogen Receptor Progesterone Receptor Luteinizing Hormone Anterior Pituitary Pituitary Cell 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • T. G. Muldoon
    • 1
  • V. B. Mahesh
    • 1
  1. 1.Department of Physiology and EndocrinologyMedical College of GeorgiaAugustaUSA

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