Receptor-Weighted Mechanistic Approach to Analysis of the Actions of Estrogen and Progesterone on Gonadotropin Secretion
Synthesis and secretion of gonadotropins from the anterior pituitary, and the end-product regulation of these processes, represents the cornerstone of reproductive physiology; to the extent that we are lacking in a thorough basic understanding of these phenomena, the superstructure of endocrine-based manipulation of reproductive function collapses. Realization of this fact accounts for the vast number of experimental approaches which have been taken to delve ever deeper into the intricacies of the complex interrelationships involved. In the early 1970’s, we joined the ranks of a small number of groups who were actively investigating the occurrence and nature of steroid hormone receptors in the anterior pituitary (Eisenfeld, 1970; Kato, 1970; Notides, 1970; Korach and Muldoon, 1973). These analyses rapidly developed into collaborative ventures between our two laboratories (Mahesh et al., 1972), investigating correlative dependencies between estrogen receptor dynamics and gonadotropin fluctuations under similarly manipulated experimental conditions. These studies were furthered by subsequent description of the estrogen retention system in the hypothalamus (Korach and Muldoon, 1974).
KeywordsEstrogen Receptor Progesterone Receptor Luteinizing Hormone Anterior Pituitary Pituitary Cell
Unable to display preview. Download preview PDF.
- Kalra SP, Kalra PS, 1982. Stimulatory role of gonadal steroids on luteinizing hormone releasing hormone secretion. In: Motta M, Zanisi M, Piva F (eds.), Pituitary Hormones and Related Peptides. New York: Academic Press, pp. 157–170Google Scholar
- Mahesh VB, 1984. Nature and mechanism of steroid modulation of gonadotropin secretion. In: Saxena BB, Catt KJ, Birnbaumer L, Martini L (eds.), Hormone Receptors in Growth and Reproduction. New York: Raven Press, pp. 201–225Google Scholar
- Mahesh VB, Muldoon TG, 1987. Integration of the effects of estradiol and progesterone in the modulation of gonadotropin secretion. J Steroid Biochem, in pressGoogle Scholar
- Mahesh VB, Muldoon TG, Eldridge JC, Korach KS, 1972. Studies on the regulation of FSH and LH secretion by gonadal steroids. In: Saxena BB, Beling CG, Gandy HM (eds.), Gonadotropins. New York: Wiley and Sons, pp. 730–748Google Scholar
- Mahesh VB, 0’Conner JL, Allen MB, 1980. In vivo methods for the study of pituitary-gonadal relationships. In: Mahesh VB, Muldoon TG, Saxena BB, Sadler WA (eds.), Functional Correlates of Hormone Receptors in Reproduction. North Holland, New York: Elsevier, pp. 45–61Google Scholar
- Muldoon TG, 1980a. Role of receptors in the mechanism of steroid hormone action in the brain. In: Motta M (ed.), The Endocrine Functions of the Brain. New York: Raven Press, pp. 51–93Google Scholar
- Muldoon TG, Singh P, Watson GH, 1982. Steroid hormone receptors and gonadotropin secretion. In: Muldoon TG, Mahesh VB, Perez-Ballester B (eds.), Recent Advances in Fertility Research, Part A. New York: Alan Liss, pp. 95–109Google Scholar
- Muldoon TG, Singh P, Watson GH, Harper SA, 1984. Molecular determinants of pituitary responsiveness to estrogen and luteinizing hormone-releasing hormone. In: Saxena BB, Catt KJ, Birnbaumer L, Martini L (eds.), Hormone Receptors in Growth and Reproduction. New York: Raven Press, pp. 237–248Google Scholar
- O’Malley BW, Sherman MR, Toft DO, Spelsberg TC, Schrader WT, Steggles AW, 1971. A specific oviduct target tissue receptor for progesterone. Adv Biosci 7:213–231Google Scholar