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Chronic Effects of Insulin and Insulin-Like Growth Factor-1 on Steroidogenesis by Rat Leydig Cells

  • William H. Moger
  • Paul R. Murphy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 219)

Abstract

There are no apparent acute effects of insulin on Leydig cell glucose transport or androgen production (Moger and Murphy, 1986). However, chronic exposure of primary cultures of rat or mouse testicular cells to insulin has been reported to increase LH-stimulated androgen production (Adashi et al., 1982; Murphy and Moger, 1982). Insulin-like growth factor-1 (IGF-1) receptors have been reported to be present on Leydig cells (Handelsman et al., 1985; Lin et al., 1986a) and recent reports have suggested an intratesticular site of IGF-1 production (D’Ercole et al., 1984; Handelsman et al., 1985). As with insulin, IGF-1 did not acutely alter androgen production by Leydig cells (Handelsman et al., 1985). The present study has compared the chronic effects of insulin and IGF-1 on androgen production by purified rat Leydig cells.

Keywords

Leydig Cell Androgen Production Androgen Secretion Leydig Cell Steroidogenesis Concentration Dependent Fashion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • William H. Moger
    • 1
    • 2
  • Paul R. Murphy
    • 3
  1. 1.Departments of Physiology and BiophysicsDalhousie UniversityHalifaxCanada
  2. 2.Departments of Obstetrics and GynecologyDalhousie UniversityHalifaxCanada
  3. 3.Department of PhysiologyUniversity of ManitobaWinnipegCanada

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