Decidual Luteotropin Secretion and Action: Its Role in Pregnancy Maintenance in the Rat

  • G. Gibori
  • P. G. Jayatilak
  • I. Khan
  • B. Rigby
  • T. Puryear
  • S. Nelson
  • Z. Herz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 219)


The decidual tissue is the result of proliferation, hypertrophy and differentiation of endometrial cells. Decidualization of the endometrial stroma accompanies implantation in several mammalian species. Man and other primate species exhibit this phenomenon, and several rodent species, of which the rat is a fine example, exhibit it to marked degree (De Feo, 1967). In humans, decidualization occurs normally with each menstrual cycle. In other species, including the rat, decidual tissue does not develop unless a stimulus is applied to a sensitized uterus. This stimulus may be either the contact of the blastocyst with the endometrium or artificial stimulation of the uterus (Lobel et al., 1965). The ability of the rat uterus to respond, however, depends on the completion of a basic hormonal sequence: exposure to progesterone for at least 48 h and to a minute amount of estrogen at the end of this period (Psychoyos, 1973; Glasser and McCormack, 1980). A state of peak uterine sensitivity then results 20–24 h following the completion of this sequence. In normal pregnancy and pseudopregnancy this occurs on day 5 (De Feo, 1967; Psychoyos, 1973), at which time the uterus is capable of responding to a variety of stimuli which elicit the decidual response. Stromal cells proliferate, hypertrophy and differentiate into decidual cells between the 5th and 11th day. Following this period, no evidence for further growth is seen. Regression of the decidual tissue begins on day 12 and necrotic changes are extensive by day 15.


Corpus Luteum Luteal Cell Decidual Cell Prolactin Receptor Progesterone Production 


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • G. Gibori
    • 1
  • P. G. Jayatilak
    • 1
  • I. Khan
    • 1
  • B. Rigby
    • 1
  • T. Puryear
    • 1
  • S. Nelson
    • 1
  • Z. Herz
    • 1
  1. 1.Department of Physiology and Biophysics, College of MedicineUniversity of IllinoisChicagoUSA

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