Receptor-Mediated Action Without Receptor Occupancy: A Function for Cell-Cell Communication in Ovarian Follicles

  • Willaim H. Fletcher
  • Craig V. Byus
  • Donal A. Walsh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 219)


In 1959 Furshpan and Potter reported the presence of electrical transmission at the crayfish giant motor synapse. Soon thereafter a similar means of cell-cell communication was described for Mauthner neurons of the goldfish brain (Furshpan and Furakawa, 1962) and for mammalian smooth muscle (Dewey and Barr, 1962). In each instance contacting cells, when impaled with microelectrodes, were found to exchange ions, (perhaps K+, Na+, Cl-) through low resistance pathways connecting adjacent cytoplasms without using extracellular routes. This ionic (or electrotonic) coupling was bidirectional and occurred with an impedance 3–4 orders of magnitude less than that of the transmembrane potential. Since these observations were made in excitable tissues (nerve and muscle) their functional significance was easily reconciled (Bennett et al., 1963).


Granulosa Cell Ovarian Follicle Intercellular Communication Protein Kinase Inhibitor Preovulatory Follicle 


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Willaim H. Fletcher
    • 1
  • Craig V. Byus
    • 2
  • Donal A. Walsh
    • 3
  1. 1.School of Medicine and J.L. Pettis Memorial VA HospitalLoma Linda UniversityLoma LindaUSA
  2. 2.Div. of Biomedical Sciences and Dept. of BiochemistryUniversity of CaliforniaRiversideUSA
  3. 3.Dept. of Biological Chemistry, School of MedicineUniversity of CaliforniaDavisUSA

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