Estrogen-Producing Ovarian Granulosa Cells: Use of the Granulosa Cell Aromatase Bioassay (GAB) to Monitor FSH Levels in Body Fluids
Pituitary follicle-stimulating hormone (FSH) is essential for the maintenance of testicular spermatogenesis and ovarian follicle development. Smith (1926,) and Zondek and Aschheim (1925) independently discovered that implants of fresh anterior pituitary into hypophysectomized animals induced an immediate and remarkable growth and maturation of the ovaries. Two apparently separate gonad-stimulating hormones were subsequently detected in menopausal women’s urine and human pituitary samples by Ascheim and Zondek (1928) and Fevold et al. (1931), respectively. The primary action of FSH is the development of ovarian follicles, whereas LH is responsible for the transformation of follicles into the corpus luteum. However, precise measurements of FSH in body fluids were not possible prior to the development of a sensitive radioimmunoassay (RIA) for FSH in 1967.
KeywordsLuteinizing Hormone Granulosa Cell Premature Ovarian Failure Aromatase Activity GnRH Antagonist
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