Androgen-Induced Changes in Ovarian Granulosa Cells from Immature Rats in Vitro

  • Everett Anderson
  • Martin Selig
  • Gloria Lee
  • Brian Little
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 219)


Since the classical description of the polycystic ovarian syndrome (PCO) by Stein and Leventhal (1935) investigators continue to be intrigued by this complex endrocrinologic disorder. Despite the continued interest, a satisfactory description of its etiology and pathogenesis in the ovary remains unexplained. In certain mammalian models, cystic ovaries have been induced by numerous manipulations, These treatments include estradiol valerate (Hemmings et al., 1978), estradiol benzoate, (Kawakami and Visessuvan, 1979), dehydroepiandrosterone (DHEA) (Roy et al., 1962), treatment with antibodies to luteinizing hormone releasing hormone, (Fraser and Baker, 1978; Popkin et al., 1983), treatment of hypothyroid rats with human chorionic gonadotropin (Copmann and Adams, 1981), treatment with testosterone propionate (Cortes et al., 1971) and constant illumination (Lawton and Schwartz, 1977) (see Singh, 1969 for various methods of producing cystic ovaries). In addition to the aforementioned treatments which produce cysts, atretic follicles are also induced.


Granulosa Cell Stress Fiber Antral Follicle Testosterone Propionate Estradiol Valerate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Everett Anderson
    • 1
    • 2
  • Martin Selig
    • 1
    • 2
  • Gloria Lee
    • 1
    • 2
  • Brian Little
    • 1
    • 2
  1. 1.Department of Anatomy and Cellular Biology and Laboratory for Human Reproduction and Reproductive BiologyHarvard Medical SchoolBostonUSA
  2. 2.Department of Obstetrics and GynecologyMcGill UniversityMontrealCanada

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