Animal Models for Study of Polycystic Ovaries and Ovarian Atresia

  • V. B. Mahesh
  • T. M. Mills
  • C. A. Bagnell
  • B. A. Conway
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 219)


In 1935, Stein and Leventhal described a syndrome in which there was an association between large, pale polycystic ovaries, menstrual irregularities, ovulatory failure, infertility, hirsutism and obesity. Isolated reports of polycystic ovaries in the human and the management of the associated infertility by partial wedge-resection of the ovaries had been reported in Europe almost a century earlier but a syndrome had not been described. Since 1935 extensive investigations have been undertaken to establish the pathophysiology of the polycystic ovary syndrome and several excellent reviews have been published on the subject (Mahesh et al., 1962; Goldzieher and Axelrod, 1963; Mahesh and Greenblatt, 1964a; Shearman and Cox, 1966; Kirschner and Bardin, 1972; Greenblatt and Mahesh, 1976; Parker and Mahesh. 1976a; Rebar et al., 1976; Mahesh, 1980, 1983, 1984; Yen, 1980, Goldzieher, 1981). In spite of the extensive research on the polycystic ovary syndrome, there is no concensus as to its pathophysiology because the so called syndrome is not a distinct entity in itself. An analysis of 1079 cases published in 1962 showed that 57% of the cases had amenorrhea, 69% hirsutism, 41% obesity, 74% infertility, 21% virilization, and 12% had cyclic menses (Goldzieher and Green, 1962). Variations were also found in the size of the ovary ranging from small to normal to large; in some cases, the tunica was thickened while in others it was not (Smith et al., 1965).


Granulosa Cell Polycystic Ovary Polycystic Ovary Syndrome Ovulatory Failure Atretic Follicle 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • V. B. Mahesh
    • 1
  • T. M. Mills
    • 1
  • C. A. Bagnell
    • 1
  • B. A. Conway
    • 1
  1. 1.Department of Physiology and EndocrinologyMedical College of GeorgiaAugustaUSA

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