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Pharmacology of DNA Binding Drugs

  • Chapter
DNA—Ligand Interactions

Part of the book series: NATO ASI Series ((volume 137))

Abstract

Many compounds from various sources have been found able to bind to nucleic acids. Among those are numerous basic dyes used to stain the chromatin in the cell nucleus, several antibiotics, plant alcaloïds and various chemicals synthetized during the last fifty years. Several of these compounds have useful pharmacological properties and are used in human and veterinary medicine for the treatment of parasitic diseases (rev. Van den Bossche, 1978). and cancers (rev. Le Pecq, 1978; Pratt and Ruddon, 1979). All these chemicals act by killing or preventing specifically the growth of target cells. A limited list of the most important derivatives is given in Table 1 with their corresponding structures shown in Figure 1.

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Authors and Affiliations

  1. Laboratoire de Pharmacologie Moléculaire (UA n°147 CNRS, U n°140 INSERM), Institut Gustave-Roussy, Rue Camille Desmoulins, Villejuif, Cedex, 94805, France

    Bernard Lambert & Jean-Bernard Le Pecq

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  1. Bernard Lambert
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  2. Jean-Bernard Le Pecq
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  1. Service de Biochimie, Bat. 142, Département de Biologie, Centre d’Etudes Nucléaires de Saclay, F-91191, Gif-sur-Yvette Cedex, France

    Wilhelm Guschlbauer (Director) (Director)

  2. Institut für Kristallographie, Freie Universität, Takustrasse 6, D-1000, Berlin 33, German Federal Republic

    Wolfram Saenger (Codirector) (Codirector)

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© 1987 Plenum Press, New York

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Lambert, B., Le Pecq, JB. (1987). Pharmacology of DNA Binding Drugs. In: Guschlbauer, W., Saenger, W. (eds) DNA—Ligand Interactions. NATO ASI Series, vol 137. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5383-6_9

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  • DOI: https://doi.org/10.1007/978-1-4684-5383-6_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5385-0

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