The Major and Minor Grooves of the DNA Helix as Conduits for Information Transfer

  • Richard E. Dickerson
  • Mary L. Kopka
  • Philip E. Pjura
Part of the NATO ASI Series book series (volume 137)


The statement that DNA is an informational macromolecule is one that has moved from being an insight, to a commonplace, to dogma, and like so many dogmas has ended as a cliché. But this picture has been given more concrete form in the last six years, with the advent of x-ray crystal structure determinations of synthetic DNA oligomers of defined sequence, both alone and complexed with control proteins such as repressors and with antitumor drugs. It is an attractive idea to a structurally-minded molecular biologist to ask precisely how the information inherent in DNA gets out, in a way that allows it to be used by the host organism.


Drug Molecule Minor Groove Alpha Helix Major Groove Piperazine Ring 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Richard E. Dickerson
    • 1
  • Mary L. Kopka
    • 1
  • Philip E. Pjura
    • 1
  1. 1.Molecular Biology InstituteUniversity of California at Los AngelesLos AngelesUSA

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