The Major and Minor Grooves of the DNA Helix as Conduits for Information Transfer
The statement that DNA is an informational macromolecule is one that has moved from being an insight, to a commonplace, to dogma, and like so many dogmas has ended as a cliché. But this picture has been given more concrete form in the last six years, with the advent of x-ray crystal structure determinations of synthetic DNA oligomers of defined sequence, both alone and complexed with control proteins such as repressors and with antitumor drugs. It is an attractive idea to a structurally-minded molecular biologist to ask precisely how the information inherent in DNA gets out, in a way that allows it to be used by the host organism.
KeywordsDrug Molecule Minor Groove Alpha Helix Major Groove Piperazine Ring
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- 1.Dickerson, R.E., Sci. Amer. (December), 94-111 (1983).Google Scholar
- 11.McClarin, J.A., Frederick, C.A., Grable, J., Samudzi, C.T., Wang, B.-C., Greene, P., Boyer, H.W. and Rosenberg, J.M., Proc. Fourth Conversation on Biomolecular Stereodynamics, 4-8 June 1985, SUNY Albany, Adenine Press, Albany (1986).Google Scholar
- 18.Kopka, M.L., Pjura, P.E., Goodsell, D.S. and Dickerson, R.E., In: “Nucleic Acids and Molecular Biology”, D. Lilley and F. Eckstein, Editors, Vol, 1, Springer-Verlag, Berlin (1986).Google Scholar
- 19.Pjura, P.E., Grzeskowiak, K. and Dickerson, R.E., submitted (1986).Google Scholar
- 22.Saenger, W., Hunter, W.N., and Kennard, O., Nature, submitted (1986).Google Scholar
- 28.Marky, L.A., Curry, J., Breslauer, K.J., in “Molecular Basis of Cancer, Part B: Macromolecular Recognition, Chemotherapy, and Immunology”, 155-173 (1985).Google Scholar